(Q35612350)

9 August 2017

Hypothalamic leucine metabolism regulates liver glucose production (English)

1 reference

9 August 2017

Ya Su

1

1 reference

9 August 2017

Tony K T Lam

2

1 reference

9 August 2017

Wu He

3

1 reference

9 August 2017

Alessandro Pocai

4

1 reference

9 August 2017

Joseph Bryan

5

1 reference

9 August 2017

Lydia Aguilar-Bryan

6

1 reference

9 August 2017

Roger Gutiérrez-Juárez

7

1 reference

9 August 2017

language of work or name

English

0 references

publication date

1 January 2012

1 reference

9 August 2017

9

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inferred from page(s)

published in

Diabetes

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9 August 2017

61

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9 August 2017

1

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9 August 2017

85-93

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

9 August 2017

start time

27 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Metabolite profiles and the risk of developing diabetes

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Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus

27 July 2018

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Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons

27 July 2018

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Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit

27 July 2018

1 reference

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

27 July 2018

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Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle

27 July 2018

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Role of dietary proteins and amino acids in the pathogenesis of insulin resistance

27 July 2018

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

27 July 2018

1 reference

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A brain-liver circuit regulates glucose homeostasis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Hypothalamic K(ATP) channels control hepatic glucose production

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Distinguishing Features of Leucine and α-Ketoisocaproate Sensing in Pancreatic β-Cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

27 July 2018

1 reference

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The TOR signal transduction cascade controls cellular differentiation in response to nutrients

27 July 2018

1 reference

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Extracellular amino acid profiles in the paraventricular nucleus of the rat hypothalamus are influenced by diet composition

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Central nervous system control of food intake

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Transport of glutamate and other amino acids at the blood-brain barrier

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

A molecular model of human branched-chain amino acid metabolism

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Bidirectional modulation of insulin action by amino acids

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Stimulation of insulin secretion by amino acids

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Characterization of response of circulating glucagon to intraduodenal and intravenous administration of amino acids

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Effect of amino acids and protein on foot intake of hyperphagic and recovered aphagic rats.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Adaptation of rats to diets containing different levels of protein: effects on food intake, plasma and brain amino acid concentrations and brain neurotransmitter metabolism.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

High levels of dietary amino and branched-chain alpha-keto acids alter plasma and brain amino acid concentrations in rats.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Effect of leucine on amino acid and glucose metabolism in humans

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Effect of different protein diets on the distribution of amino acids in plasma, liver and brain in the rat

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Amino Acid Metabolism in Man

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Effect of starvation on the turnover and metabolic response to leucine

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Hypothalamic mTOR signaling regulates food intake

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Molecular disruption of hypothalamic nutrient sensing induces obesity

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Long-term effects of popular dietary approaches on weight loss and features of insulin resistance

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Regulation of blood glucose by hypothalamic pyruvate metabolism

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

A nutrient sensor mechanism controls Drosophila growth.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

The metabolic response of subjects with type 2 diabetes to a high-protein, weight-maintenance diet

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Hypothalamic insulin signaling is required for inhibition of glucose production

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Central administration of oleic acid inhibits glucose production and food intake

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Effect of dietary protein on in vivo insulin action and liver glycogen repletion.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3237640

Inhibition of branched chain alpha-ketoacid dehydrogenase kinase activity by alpha-chloroisocaproate

25 September 2018

1 reference

12 December 2020

Procedures for the chromatographic determination of amino acids on four per cent cross-linked sulfonated polystyrene resins

1 reference

12 December 2020

A chromatographic investigation of the amino acid constituents of normal urine

1 reference

12 December 2020

Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB11-0857

1 reference

release_kceplmu3xnfsreoswcnhxvfeeq

9 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kceplmu3xnfsreoswcnhxvfeeq

24 November 2022

mapped directly with Wikidata item

PMCID

3237640

1 reference

9 August 2017

1 reference