(Q35613317)

9 August 2017

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title

Molecular determinants of virulence: the structural and functional basis for flavivirus attenuation (English)

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9 August 2017

Robert J Hurrelbrink

1

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9 August 2017

Peter C McMinn

series ordinal

2

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9 August 2017

publication date

1 January 2003

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Advances in Virus Research

9 August 2017

published in

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9 August 2017

volume

60

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9 August 2017

page(s)

1-42

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Mutational Evidence for an Internal Fusion Peptide in Flavivirus Envelope Protein E

9 August 2017

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Molecular basis for attenuation of neurovirulence of a yellow fever Virus/Japanese encephalitis virus chimera vaccine (ChimeriVax-JE).

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7 January 2021

Flaviviridae polymerase and RNA replication

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7 January 2021

Biophysical Characterization and Vector-Specific Antagonist Activity of Domain III of the Tick-Borne Flavivirus Envelope Protein

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7 January 2021

Chemical mutagenesis of dengue virus type 4 yields mutant viruses which are temperature sensitive in vero cells or human liver cells and attenuated in mice

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7 January 2021

Comparison of a dengue-2 virus and its candidate vaccine derivative: Sequence relationships with the flaviviruses and other viruses

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7 January 2021

Growth-restricted dengue virus mutants containing deletions in the 5' noncoding region of the RNA genome

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7 January 2021

Infectious cDNA clones of Langat tick-borne flavivirus that differ from their parent in peripheral neurovirulence

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7 January 2021

Construction, characterization and immunogenicity of recombinant yellow fever 17D-dengue type 2 viruses

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7 January 2021

Nucleotide changes responsible for loss of neuroinvasiveness in Japanese encephalitis virus neutralization-resistant mutants

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7 January 2021

Flavivirus genome organization, expression, and replication

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7 January 2021

West Nile virus envelope proteins: nucleotide sequence analysis of strains differing in mouse neuroinvasiveness

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7 January 2021

Neuroadapted yellow fever virus 17D: genetic and biological characterization of a highly mouse-neurovirulent virus and its infectious molecular clone

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7 January 2021

Generation and characterization of organ-tropism mutants of Japanese encephalitis virus in vivo and in vitro

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7 January 2021

Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

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7 January 2021

Mutations in the NS3 gene and 3'-NCR of Japanese encephalitis virus isolated from an unconventional ecosystem and implications for natural attenuation of the virus

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7 January 2021

Membrane fusion activity of tick-borne encephalitis virus and recombinant subviral particles in a liposomal model system

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7 January 2021

Characterization of novel viral polyproteins detected in cells infected by the flavivirus Kunjin and radiolabelled in the presence of the leucine analogue hydroxyleucine

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7 January 2021

Monoclonal Antibodies That Bind to Domain III of Dengue Virus E Glycoprotein Are the Most Efficient Blockers of Virus Adsorption to Vero Cells

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7 January 2021

Complete nucleotide sequence of yellow fever virus vaccine strains 17DD and 17D-213.

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7 January 2021

Determinants in the envelope E protein and viral RNA helicase NS3 that influence the induction of apoptosis in response to infection with dengue type 1 virus.

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7 January 2021

Entry of neurotropic arboviruses into the central nervous system: an in vitro study using mouse brain endothelium

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7 January 2021

Attenuation and immunogenicity in humans of a live dengue virus type-4 vaccine candidate with a 30 nucleotide deletion in its 3'-untranslated region.

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7 January 2021

Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus

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7 January 2021

Identification of naturally occurring monoclonal antibody escape variants of louping ill virus

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7 January 2021

Expression of wild-type and mutant forms of influenza hemagglutinin: the role of folding in intracellular transport

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7 January 2021

N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases

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7 January 2021

The degree of attenuation of tick-borne encephalitis virus depends on the cumulative effects of point mutations

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7 January 2021

Identification of a major determinant of mouse neurovirulence of dengue virus type 2 using stably cloned genomic-length cDNA.

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7 January 2021

The Murray Valley encephalitis virus prM protein confers acid resistance to virus particles and alters the expression of epitopes within the R2 domain of E glycoprotein

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7 January 2021

Epitope model of tick-borne encephalitis virus envelope glycoprotein E: analysis of structural properties, role of carbohydrate side chain, and conformational changes occurring at acidic pH.

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7 January 2021

Fusion activity of flaviviruses: comparison of mature and immature (prM-containing) tick-borne encephalitis virions

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Selection and partial characterization of dengue 2 virus mutants that induce fusion at elevated pH.

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Recombinant chimeric yellow fever-dengue type 2 virus is immunogenic and protective in nonhuman primates

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever-Japanese encephalitis virus (ChimeriVax-JE) as a live, attenuated vaccine candidate against Japanese encephalitis

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it.

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Conserved elements in the 3' untranslated region of flavivirus RNAs and potential cyclization sequences

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7 January 2021

Loss of dimerisation of the nonstructural protein NS1 of Kunjin virus delays viral replication and reduces virulence in mice, but still allows secretion of NS1.

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7 January 2021

Paired charge-to-alanine mutagenesis of dengue virus type 4 NS5 generates mutants with temperature-sensitive, host range, and mouse attenuation phenotypes

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7 January 2021

Mutations in the envelope protein of Japanese encephalitis virus affect entry into cultured cells and virulence in mice

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7 January 2021

Structural changes and functional control of the tick-borne encephalitis virus glycoprotein E by the heterodimeric association with protein prM

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7 January 2021

Mutational analysis of a neutralization epitope on the dengue type 2 virus (DEN2) envelope protein: monoclonal antibody resistant DEN2/DEN4 chimeras exhibit reduced mouse neurovirulence

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7 January 2021

The French neurotropic vaccine strain of yellow fever virus accumulates mutations slowly during passage in cell culture

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7 January 2021

Amino acid substitution(s) in the stem-anchor region of langat virus envelope protein attenuates mouse neurovirulence

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7 January 2021

Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Attenuation of Murray Valley encephalitis virus by site-directed mutagenesis of the hinge and putative receptor-binding regions of the envelope protein

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Characterization of Langat virus antigenic determinants defined by monoclonal antibodies to E, NS1 and preM and identification of a protective, non-neutralizing preM-specific monoclonal antibody

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Analysis of a yellow fever virus isolated from a fatal case of vaccine-associated human encephalitis

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Comparison of the nucleotide and deduced amino acid sequences of the envelope protein genes of the wild-type French viscerotropic strain of yellow fever virus and the live vaccine strain, French neurotropic vaccine, derived from it.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Single amino acid codon changes detected in louping ill virus antibody-resistant mutants with reduced neurovirulence

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

A small region of the dengue virus-encoded RNA-dependent RNA polymerase, NS5, confers interaction with both the nuclear transport receptor importin-beta and the viral helicase, NS3.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Japanese encephalitis: immunocytochemical studies of viral antigen and inflammatory cells in fatal cases.

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Essential role of cyclization sequences in flavivirus RNA replication

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus

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7 January 2021

Modification of the cytoplasmic domain of influenza virus hemagglutinin affects enlargement of the fusion pore

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7 January 2021

Structure of dengue virus: implications for flavivirus organization, maturation, and fusion

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7 January 2021

Mutations in the Yellow Fever Virus Nonstructural Protein NS2A Selectively Block Production of Infectious Particles

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7 January 2021

Change in phenotype of tick-borne encephalitis virus following passage in Ixodes ricinus ticks and associated amino acid substitution in the envelope protein

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7 January 2021

Substitutions at the putative receptor-binding site of an encephalitic flavivirus alter virulence and host cell tropism and reveal a role for glycosaminoglycans in entry

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Mechanism of virulence attenuation of glycosaminoglycan-binding variants of Japanese encephalitis virus and Murray Valley encephalitis virus

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7 January 2021

Changes in the dengue virus major envelope protein on passaging and their localization on the three-dimensional structure of the protein

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7 January 2021

Cell proteins TIA-1 and TIAR interact with the 3' stem-loop of the West Nile virus complementary minus-strand RNA and facilitate virus replication

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7 January 2021

Host cell selection of Murray Valley encephalitis virus variants altered at an RGD sequence in the envelope protein and in mouse virulence

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7 January 2021

Attenuation of tick-borne encephalitis virus by structure-based site-specific mutagenesis of a putative flavivirus receptor binding site

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses

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7 January 2021

Derivation and characterization of a dengue type 1 host range-restricted mutant virus that is attenuated and highly immunogenic in monkeys

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7 January 2021

Mutagenesis of the dengue virus type 2 NS3 proteinase and the production of growth-restricted virus

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7 January 2021

Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication

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7 January 2021

A comparison of the spread of Murray Valley encephalitis viruses of high or low neuroinvasiveness in the tissues of Swiss mice after peripheral inoculation

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7 January 2021

Murray valley encephalitis virus envelope protein antigenic variants with altered hemagglutination properties and reduced neuroinvasiveness in mice

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7 January 2021

A mouse-attenuated envelope protein variant of Murray Valley encephalitis virus with altered fusion activity

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7 January 2021

Single mutation in the flavivirus envelope protein hinge region increases neurovirulence for mice and monkeys but decreases viscerotropism for monkeys: relevance to development and safety testing of live, attenuated vaccines

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7 January 2021

Recombinant, chimaeric live, attenuated vaccine (ChimeriVax) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in non-hu

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7 January 2021

Processing of the dengue virus type 2 proteins prM and C-prM.

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7 January 2021

Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects

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7 January 2021

Mutagenesis of the N-linked glycosylation sites of the yellow fever virus NS1 protein: effects on virus replication and mouse neurovirulence

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7 January 2021

Mutagenesis of the yellow fever virus NS2A/2B cleavage site: effects on proteolytic processing, viral replication, and evidence for alternative processing of the NS2A protein

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7 January 2021

Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14.

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7 January 2021

Attenuation of Japanese encephalitis virus by selection of its mouse brain membrane receptor preparation escape variants

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7 January 2021

Nucleotide sequence of the virulent SA-14 strain of Japanese encephalitis virus and its attenuated vaccine derivative, SA-14-14-2.

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7 January 2021

Analyses of the terminal sequences of West Nile virus structural proteins and of the in vitro translation of these proteins allow the proposal of a complete scheme of the proteolytic cleavages involved in their synthesis

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Infectious cDNA clone of attenuated Langat tick-borne flavivirus (strain E5) and a 3' deletion mutant constructed from it exhibit decreased neuroinvasiveness in immunodeficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Tick-Borne Langat/Mosquito-Borne Dengue Flavivirus Chimera, a Candidate Live Attenuated Vaccine for Protection against Disease Caused by Members of the Tick-Borne Encephalitis Virus Complex: Evaluation in Rhesus Monkeys and in Mosquitoes

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7 January 2021

Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Attenuation of the Langat tick-borne flavivirus by chimerization with mosquito-borne flavivirus dengue type 4

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Secondary structure of the 3' untranslated region of flaviviruses: similarities and differences

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Growth restriction of dengue virus type 2 by site-specific mutagenesis of virus-encoded glycoproteins

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

The effects of site-directed mutagenesis on the dimerization and secretion of the NS1 protein specified by dengue virus

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Glycosylation mutants of dengue virus NS1 protein

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Site-directed mutagenesis of the tick-borne encephalitis virus NS3 gene reveals the putative serine protease domain of the NS3 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Specific single or double proline substitutions in the "spring-loaded" coiled-coil region of the influenza hemagglutinin impair or abolish membrane fusion activity

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7 January 2021

Louping-ill encephalomyelitis in the sheep. I. The relationship of viraemia and the antibody response to susceptibility

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7 January 2021

The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Virus-encoded proteinases of the Flaviviridae

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Mutation in a 17D-204 vaccine substrain-specific envelope protein epitope alters the pathogenesis of yellow fever virus in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Antigenic variants of yellow fever virus with an altered neurovirulence phenotype in mice

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Membrane fusion process of Semliki Forest virus. II: Cleavage-dependent reorganization of the spike protein complex controls virus entry

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

A single nucleotide change in the E protein gene of dengue virus 2 Mexican strain affects neurovirulence in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Replication of yellow fever virus in the mouse central nervous system: comparison of neuroadapted and non-neuroadapted virus and partial sequence analysis of the neuroadapted strain

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Evidence for the Existence of a Pseudoknot Structure at the 3‘ Terminus of the Flavivirus Genomic RNA †

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Studies using double mutants of the conformational transitions in influenza hemagglutinin required for its membrane fusion activity

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Membrane interactions of the tick-borne encephalitis virus fusion protein E at low pH.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Characterization of a highly attenuated Japanese encephalitis virus generated from molecularly cloned cDNA.

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Mov34 protein from mouse brain interacts with the 3' noncoding region of Japanese encephalitis virus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Mutagenesis of the RGD motif in the yellow fever virus 17D envelope protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Chimeric yellow fever/dengue virus as a candidate dengue vaccine: quantitation of the dengue virus-specific CD8 T-cell response

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Characterization and complete genome sequences of high- and low- virulence variants of tick-borne encephalitis virus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

In vitro synthesis of West Nile virus proteins indicates that the amino-terminal segment of the NS3 protein contains the active centre of the protease which cleaves the viral polyprotein after multiple basic amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Human skin Langerhans cells are targets of dengue virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Mutation in NS5 protein attenuates mouse neurovirulence of yellow fever 17D vaccine virus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

In vitro RNA synthesis from exogenous dengue viral RNA templates requires long range interactions between 5'- and 3'-terminal regions that influence RNA structure

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

A novel in vitro replication system for Dengue virus. Initiation of RNA synthesis at the 3'-end of exogenous viral RNA templates requires 5'- and 3'-terminal complementary sequence motifs of the viral RNA.

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7 January 2021

Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro

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7 January 2021

NS2B-3 proteinase-mediated processing in the yellow fever virus structural region: in vitro and in vivo studies

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7 January 2021

Translation elongation factor-1 alpha interacts with the 3' stem-loop region of West Nile virus genomic RNA

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Genetic determinants responsible for acquisition of dengue type 2 virus mouse neurovirulence.

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7 January 2021

Mutagenesis of the yellow fever virus NS2B protein: effects on proteolytic processing, NS2B-NS3 complex formation, and viral replication

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7 January 2021

RNA-protein interactions: involvement of NS3, NS5, and 3' noncoding regions of Japanese encephalitis virus genomic RNA

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7 January 2021

Construction of intertypic chimeric dengue viruses exhibiting type 3 antigenicity and neurovirulence for mice

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https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Epitope mapping of flavivirus glycoproteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Genetic interaction of flavivirus nonstructural proteins NS1 and NS4A as a determinant of replicase function.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Chimeric tick-borne encephalitis and dengue type 4 viruses: effects of mutations on neurovirulence in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Structural requirements for low-pH-induced rearrangements in the envelope glycoprotein of tick-borne encephalitis virus

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Mutagenesis of the NS3 protease of dengue virus type 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

Identification of specific nucleotide sequences within the conserved 3'-SL in the dengue type 2 virus genome required for replication

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2803%2960001-1

7 January 2021

10.1016/S0065-3527(03)60001-1

Identifiers

DOI

1 reference

9 August 2017

1 reference