(Q35620660)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

review article

1 reference

title

Progress towards prediction of human pharmacokinetic parameters from in vitro technologies (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

author name string

J Brian Houston

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

language of work or name

English

0 references

publication date

1 November 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

published in

Drug Metabolism Reviews

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

volume

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

page(s)

393-415

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

FDA evaluations using in vitro metabolism to predict and interpret in vivo metabolic drug-drug interactions: impact on labeling.

17 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Minimal in vivo activation of CYP2C9-mediated flurbiprofen metabolism by dapsone

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Sense and nonsense in the prediction of drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Interspecies scaling: predicting clearance of drugs in humans. Three different approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: the need for quantitative databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Enzyme kinetics of cytochrome P450-mediated reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human udp-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Heterotropic cooperativity of cytochrome P450 3A4 and potential drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Differential modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1)-catalyzed estradiol-3-glucuronidation by the addition of UGT1A1 substrates and other compounds to human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Inhibition-based metabolic drug-drug interactions: predictions from in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Effect of omeprazole on diazepam disposition in the rat: in vitro and in vivo studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Is there a toxicological advantage for non-hyperbolic kinetics in cytochrome P450 catalysis? Functional allostery from "distributive catalysis"

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Relationship between enoxacin and ciprofloxacin plasma concentrations and theophylline disposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Elucidation of distinct ligand binding sites for cytochrome P450 3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-120026870

21 January 2018

Identifiers

DOI

10.1081/DMR-120026870

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14705868%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference