(Q35624491)

9 August 2017

title

Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves (English)

1 reference

9 August 2017

0 references

1 reference

Loren E Dupuis

1

1 reference

9 August 2017

Hanna Osinska

2

1 reference

9 August 2017

Michael B Weinstein

3

1 reference

9 August 2017

Robert B Hinton

4

1 reference

9 August 2017

Christine B Kern

5

1 reference

9 August 2017

publication date

24 March 2013

1 reference

Journal of Molecular and Cellular Cardiology

9 August 2017

published in

1 reference

9 August 2017

volume

60

1 reference

9 August 2017

page(s)

50-59

1 reference

Bicuspid aortic valve disease: a comprehensive review.

9 August 2017

cites work

1 reference

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Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development

12 July 2018

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12 July 2018

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Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes

12 July 2018

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12 July 2018

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Cardiovascular defects in a mouse model of HOXA1 syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis

12 July 2018

1 reference

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Transforming growth factor Beta2 is required for valve remodeling during heart development

12 July 2018

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Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders

12 July 2018

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Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease

12 July 2018

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Loss of Gata5 in mice leads to bicuspid aortic valve

12 July 2018

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Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling

12 July 2018

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Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves

12 July 2018

1 reference

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Bicuspid aortic valve disease

12 July 2018

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Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation

12 July 2018

1 reference

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Versican facilitates chondrocyte differentiation and regulates joint morphogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Reduced sox9 function promotes heart valve calcification phenotypes in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Transcriptional regulation of heart valve progenitor cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.

12 July 2018

1 reference

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Origin and fate of cardiac mesenchyme

12 July 2018

1 reference

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Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo

12 July 2018

1 reference

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Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Versican proteolysis mediates myocardial regression during outflow tract development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Aneurysm syndromes caused by mutations in the TGF-beta receptor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

The interaction of versican with its binding partners

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Mutations in NOTCH1 cause aortic valve disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Effects of rat urotensin II on coronary flow and myocardial eNOS protein expression in isolated rat heart

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Development of the heart: (3) formation of the ventricular outflow tracts, arterial valves, and intrapericardial arterial trunks

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Septation and separation within the outflow tract of the developing heart

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Filamin associates with Smads and regulates transforming growth factor-beta signaling

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

A novel role for cardiac neural crest in heart development

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Clinical significance of the bicuspid aortic valve

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Collagen composition of normal and myxomatous human mitral heart valves

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

The inter-relationship of periostin, TGF beta, and BMP in heart valve development and valvular heart diseases.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Bicuspid aortic valves with different spatial orientations of the leaflets are distinct etiological entities.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Proteolytic cleavage of versican during cardiac cushion morphogenesis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Adamts9 is widely expressed during mouse embryo development.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Shear stress induces eNOS mRNA expression and improves endothelium-dependent dilation in senescent soleus muscle feed arteries

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Abnormal aortic valve development in mice lacking endothelial nitric oxide synthase

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4437693

Risk factors for aortic valve disease in bicuspid aortic valve: A family-based study

23 October 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2013.03.010

The epidemiology of valvular heart diseases: the problem is growing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2013.03.010

Bicuspid pulmonary valve with atrial septal defect leading to pulmonary aneurysm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2013.03.010

7 January 2021

Bicuspid pulmonic valve

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2013.03.010

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2013.03.010

Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2013.03.010

Activation of TGF-β Receptors and Smad Proteins by Atorvastatin is Related to Reduced Atherogenesis in ApoE/LDLR Double Knockout Mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2013.03.010

Endothelial Nitric Oxide Synthase in Bicuspid Aortic Valve Disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2013.03.010

Bilateral semilunar valve disease in a child with partial deletion of the Williams-Beuren syndrome region is associated with elastin haploinsufficiency

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23531444

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23531444

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.YJMCC.2013.03.010

1 reference

9 August 2017

1 reference

9 August 2017

1 reference