(Q35625347)

9 August 2017

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title

Pharmacokinetics of local anaesthetics in infants and children (English)

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9 August 2017

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Jean-Xavier Mazoit

1

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PubMed ID

14715049

9 August 2017

Bernard J Dalens

series ordinal

2

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9 August 2017

1 January 2004

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Clinical Pharmacokinetics

9 August 2017

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9 August 2017

43

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9 August 2017

1

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9 August 2017

17-32

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https://scigraph.springernature.com/pub.10.2165/00003088-200443010-00002

9 August 2017

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Caudal analgesia: a simple and safe technique in paediatric surgery.

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Electrophysiologic and arrhythmogenic effects of bupivacaine. A study with high-resolution ventricular epicardial mapping in rabbit hearts

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Plasma bupivacaine levels after fascia iliaca compartment block with and without adrenaline.

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12 December 2020

Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers

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Anatomical-physiological approaches in pharmacokinetics and pharmacodynamics.

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Clinical pharmacokinetics of epidural and spinal anaesthesia

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Drug binding to human alpha-1-acid glycoprotein in health and disease

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12 December 2020

Plasma concentrations and pharmacokinetics of bupivacaine with and without adrenaline following caudal anaesthesia in infants.

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12 December 2020

Pharmacokinetics of local anaesthetics

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12 December 2020

Ropivacaine pharmacokinetics after caudal block in 1-8 year old children

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12 December 2020

Pharmacokinetics and clinical efficacy of long-term epidural ropivacaine infusion in children.

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12 December 2020

Perioperative changes in alpha 1-acid glycoprotein concentrations in infants undergoing major surgery

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12 December 2020

Bupivacaine in children: pharmacokinetics following caudal anesthesia.

1 reference

12 December 2020

Intraindividual and interindividual variability in the disposition of the local anesthetic ropivacaine in healthy subjects.

1 reference

12 December 2020

Efficacy and kinetics of extradural ropivacaine: comparison with bupivacaine.

1 reference

12 December 2020

Plasma protein binding displacement interactions--why are they still regarded as clinically important?

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12 December 2020

Enhancement by ischemia of the risk of cardiac disorders, especially fibrillation, in regional anesthesia with bupivacaine

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12 December 2020

Potentiation by mild hypothermia of ventricular conduction disturbances and reentrant arrhythmias induced by bupivacaine in dogs.

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12 December 2020

Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers

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12 December 2020

Acute toxicity of ropivacaine compared with that of bupivacaine.

1 reference

12 December 2020

The pharmacokinetics of epidural ropivacaine in infants and young children

1 reference

12 December 2020

Pharmacokinetics of the enantiomers of bupivacaine following intravenous administration of the racemate

1 reference

12 December 2020

Comparative ventricular electrophysiologic effect of racemic bupivacaine, levobupivacaine, and ropivacaine on the isolated rabbit heart.

1 reference

12 December 2020

Binding of anilide-type local anesthetics in human plasma. I. Relationships between binding, physicochemical properties, and anesthetic activity.

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12 December 2020

Local anaesthetic plasma levels in children

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12 December 2020

Epidural anesthesia with lidocaine and bupivacaine: effects of epinephrine on the plasma concentration profiles.

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12 December 2020

A comparison of the cardiovascular effects of levobupivacaine and rac-bupivacaine following intravenous administration to healthy volunteers

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12 December 2020

Alpha 1-acid glycoprotein and albumin in human serum bupivacaine binding.

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12 December 2020

Caudal anaesthesia in children and spread of 1 per cent lignocaine. A statistical study.

1 reference

12 December 2020

Free and total bupivacaine plasma concentrations after continuous epidural anaesthesia in infants and children.

1 reference

12 December 2020

Cauda equina syndrome after continuous spinal anesthesia

1 reference

12 December 2020

Caudal anesthesia in children and the distribution of 0.25 per cent bupivacaine solution. A statistical study

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12 December 2020

A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy

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12 December 2020

Lumbar and thoracic epidural anesthesia for urologic and upper abdominal surgery in infants and children.

1 reference

12 December 2020

The pharmacokinetics of bupivacaine following interpleural nerve block in infants of very low birthweight.

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12 December 2020

Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: an interaction study with fluvoxamine and ketoconazole as in vivo inhibitors.

1 reference

12 December 2020

Cauda equina syndrome and continuous spinal anesthesia

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12 December 2020

Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes.

1 reference

12 December 2020

Continuous epidural infusion of bupivacaine for postoperative pain relief in children.

1 reference

12 December 2020

Enhancement by hyponatremia and hyperkalemia of ventricular conduction and rhythm disorders caused by bupivacaine

1 reference

12 December 2020

Pharmacokinetics of bupivacaine after continuous epidural infusion in infants with and without biliary atresia

1 reference

12 December 2020

Cardiac Arrest Following Regional Anesthesia with Etidocaine or Bupivacaine

1 reference

12 December 2020

1 reference

12 December 2020

Nebulized lidocaine administered to infants and children undergoing flexible bronchoscopy.

1 reference

12 December 2020

Transient neurologic symptoms after epidural analgesia.

1 reference

12 December 2020

Transient neurologic symptoms after spinal anesthesia: an epidemiologic study of 1,863 patients

1 reference

12 December 2020

Systemic absorption and block after epidural injection of ropivacaine in healthy volunteers.

1 reference

12 December 2020

Pharmacokinetics of bupivacaine during postoperative epidural infusion: enantioselectivity and role of protein binding

1 reference

12 December 2020

Pharmacokinetics and analgesic effect of ropivacaine following ilioinguinal/iliohypogastric nerve block in children

1 reference

12 December 2020

Bupivacaine disposition in mother, fetus, and neonate after spinal anesthesia for cesarean section.

1 reference

12 December 2020

Ropivacaine undergoes slower systemic absorption from the caudal epidural space in children than bupivacaine

1 reference

12 December 2020

Pharmacokinetics of lignocaine and bupivacaine in surgical patients following epidural administration. Simultaneous investigation of absorption and disposition kinetics using stable isotopes.

1 reference

12 December 2020

Transient neurologic symptoms after epidural analgesia in a five-year-old child

1 reference

12 December 2020

Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers.

1 reference

12 December 2020

Direct effects of ropivacaine and bupivacaine on spinal pial vessels in canine. Assessment with closed spinal window technique.

1 reference

12 December 2020

Epidural infusion of ropivacaine for postoperative analgesia after major orthopedic surgery: pharmacokinetic evaluation.

1 reference

12 December 2020

The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes

1 reference

12 December 2020

Effects of pronounced haemodilution on the plasma protein binding of lidocaine.

1 reference

12 December 2020

Bupivacaine-induced cardiac toxicity in neonates: successful treatment with intravenous phenytoin.

1 reference

12 December 2020

Sciatic nerve blockade in infant, adolescent, and adult rats: a comparison of ropivacaine with bupivacaine.

1 reference

12 December 2020

Smaller children have greater bupivacaine plasma concentrations after ilioinguinal block.

1 reference

12 December 2020

Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A

1 reference

12 December 2020

The impairment of lignocaine clearance by propranolol--major contribution from enzyme inhibition

1 reference

12 December 2020

The effects of age, epinephrine, and operative site on duration of caudal analgesia in pediatric patients.

1 reference

12 December 2020

The effect of age on the systemic absorption, disposition and pharmacodynamics of bupivacaine after epidural administration.

1 reference

12 December 2020

Lidocaine plasma concentrations in pediatric patients after providing airway topical anesthesia from a calibrated device.

1 reference

12 December 2020

New regimen for interpleural block in children.

1 reference

12 December 2020

Lidocaine pharmacokinetics and toxicity in newborn pigs

1 reference

12 December 2020

Interpleural analgesia with bupivacaine following thoracotomy: ineffective results of a controlled study and pharmacokinetics

1 reference

12 December 2020

Caudal ropivacaine in infants: population pharmacokinetics and plasma concentrations

1 reference

12 December 2020

Pharmacokinetics of bupivacaine following caudal anesthesia in infants.

1 reference

12 December 2020

Regional anesthesia and local anesthetic-induced systemic toxicity: seizure frequency and accompanying cardiovascular changes.

1 reference

12 December 2020

The death of a healthy volunteer in a human research project: implications for Australian clinical research.

1 reference

12 December 2020

Developmental changes in the effects of lidocaine on sodium channels in rat cardiac myocytes

1 reference

12 December 2020

Pharmacokinetics of lidocaine after prolonged intravenous infusions in uncomplicated myocardial infarction.

1 reference

12 December 2020

Comparison of ropivacaine 0.1% and 0.2% with bupivacaine 0.2% for single-shot caudal anaesthesia in children

1 reference

12 December 2020

Bupivacaine pharmacokinetics during epidural anaesthesia in children

1 reference

12 December 2020

Epidemiology and morbidity of regional anesthesia in children: a one-year prospective survey of the French-Language Society of Pediatric Anesthesiologists.

1 reference

12 December 2020

The electrophysiologic effects of bupivacaine on adult, neonatal, and fetal guinea pig papillary muscles

1 reference

12 December 2020

Pharmacokinetics of bupivacaine after short and prolonged infusions in conscious dogs.

1 reference

12 December 2020

Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep

1 reference

12 December 2020

Binding of bupivacaine to human serum proteins, isolated albumin and isolated alpha-1-acid glycoprotein. Differences between the two enantiomers are partly due to cooperativity.

1 reference

12 December 2020

Lidocaine for treatment of severe seizures in newborn infants. I. Clinical effects and cerebral electrical activity monitoring.

1 reference

12 December 2020

Transient neurologic symptoms after spinal anesthesia.

1 reference

12 December 2020

The differential effects of stereoisomers of ropivacaine and bupivacaine on cerebral pial arterioles in dogs

1 reference

12 December 2020

Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450.

1 reference

12 December 2020

Pharmacokinetics of ropivacaine and bupivacaine during 21 hours of continuous epidural infusion in healthy male volunteers.

1 reference

12 December 2020

Bupivacaine plasma concentrations during continuous epidural anesthesia in infants and children.

1 reference

12 December 2020

10.2165/00003088-200443010-00002

Identifiers

DOI

1 reference

PubMed ID

14715049

Dimensions Publication ID

9 August 2017

0 references

1 reference

PubMed ID

14715049