(Q35626853)

9 August 2017

title

Metabolomic screening and identification of the bioactivation pathways of ritonavir (English)

1 reference

9 August 2017

1 reference

Feng Li

1

1 reference

9 August 2017

Jie Lu

series ordinal

2

1 reference

9 August 2017

Xiaochao Ma

series ordinal

3

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9 August 2017

publication date

17 November 2011

1 reference

Chemical Research in Toxicology

9 August 2017

published in

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9 August 2017

volume

24

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9 August 2017

issue

12

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9 August 2017

page(s)

2109-2114

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Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

9 August 2017

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12 July 2018

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12 July 2018

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12 July 2018

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Unexpected Hepatotoxicity of Rifampin and Saquinavir/Ritonavir in Healthy Male Volunteers

12 July 2018

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Hepatotoxicity and gastrointestinal intolerance when healthy volunteers taking rifampin add twice-daily atazanavir and ritonavir

12 July 2018

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High incidence of adverse events in healthy volunteers receiving rifampicin and adjusted doses of lopinavir/ritonavir tablets

12 July 2018

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Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Drug bioactivation, covalent binding to target proteins and toxicity relevance

12 July 2018

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12 July 2018

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Toxicophores: groups and metabolic routes associated with increased safety risk

12 July 2018

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Sulfotransferases in the bioactivation of xenobiotics

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

12 July 2018

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Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor

12 July 2018

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Nephrotoxicity of thiazoles structurally related to thiabendazole in mice depleted of glutathione by treatment with buthionine sulfoximine

12 July 2018

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HIV monotherapy with ritonavir-boosted protease inhibitors: a systematic review

12 July 2018

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Rapid screening and characterization of drug metabolites using a multiple ion monitoring-dependent MS/MS acquisition method on a hybrid triple quadrupole-linear ion trap mass spectrometer

25 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3243766

Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital

25 September 2018

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Structural elucidation of metabolites of ritonavir and indinavir by liquid chromatography-mass spectrometry

25 September 2018

1 reference

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Metabolism of the human immunodeficiency virus protease inhibitors indinavir and ritonavir by human intestinal microsomes and expressed cytochrome P4503A4/3A5: mechanism-based inactivation of cytochrome P4503A by ritonavir.

25 September 2018

1 reference

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Possible role of thioformamide as a proximate toxicant in the nephrotoxicity of thiabendazole and related thiazoles in glutathione-depleted mice: structure-toxicity and metabolic studies

25 September 2018

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Highlights from the FDA antiviral drug advisory committee meetings, February 27-March 1, 1996

25 September 2018

1 reference

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Metabolism and disposition of the HIV-1 protease inhibitor ritonavir (ABT-538) in rats, dogs, and humans

25 September 2018

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12 December 2020

Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole

1 reference

12 December 2020

Toxicity of antiretroviral agents

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12 December 2020

Relative hepatotoxicity of 2-(substituted phenyl)thiazoles and substituted thiobenzamides in mice: evidence for the involvement of thiobenzamides as ring cleavage metabolites in the hepatotoxicity of 2-phenylthiazoles

1 reference

12 December 2020

Identifiers

DOI

10.1021/TX2004147

1 reference

9 August 2017

1 reference

9 August 2017

1 reference