(Q35630135)

English

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

scientific article published on January 2006

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scholarly article

1 reference

Europe PubMed Central

9 August 2017

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis (English)

1 reference

Europe PubMed Central

9 August 2017

0 references

0 references

Clare E. Hughes

object named as

Clare E Hughes

5

0 references

1

object named as

Jan Bondeson

1 reference

Europe PubMed Central

9 August 2017

author name string

Shane D Wainwright

2

1 reference

Europe PubMed Central

9 August 2017

Sarah Lauder

3

1 reference

Europe PubMed Central

9 August 2017

Nick Amos

4

1 reference

Europe PubMed Central

9 August 2017

publication date

1 January 2006

1 reference

Europe PubMed Central

9 August 2017

Arthritis Research and Therapy

1 reference

Europe PubMed Central

9 August 2017

8

1 reference

Europe PubMed Central

9 August 2017

6

1 reference

Europe PubMed Central

9 August 2017

R187

1 reference

Europe PubMed Central

9 August 2017

https://scigraph.springernature.com/pub.10.1186/ar2099

0 references

An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Lessons learned from nine clinical trials of disease-modifying osteoarthritis drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Synovial macrophage-osteoclast differentiation in inflammatory arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Anticytokine therapy for osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Effects of intraarticular glucocorticoids on macrophage infiltration and mediators of joint damage in osteoarthritis synovial membranes: findings in a double-blind, placebo-controlled study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Mechanisms involved in cartilage proteoglycan catabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Catabolism of aggrecan, decorin and biglycan in tendon.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

The role of cytokines as inflammatory mediators in osteoarthritis: lessons from animal models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Degradative enzymes in osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Cytokines and their role in the pathophysiology of osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Clinical trials of a stromelysin inhibitor. Osteoarthritis, matrix metalloproteinase inhibition, cartilage loss, surrogate markers, and clinical implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Design and synthetic considerations of matrix metalloproteinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Efficient adenoviral infection with IkappaB alpha reveals that macrophage tumor necrosis factor alpha production in rheumatoid arthritis is NF-kappaB dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Cytokine inducible matrix metalloproteinase expression in immortalized rat chondrocytes is independent of nitric oxide stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

27 July 2018

Adenoviral gene transfer into osteoarthritis synovial cells using the endogenous inhibitor IkappaBalpha reveals that most, but not all, inflammatory and destructive mediators are NFkappaB dependent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Successful treatment of inflammatory knee osteoarthritis with tumour necrosis factor blockade

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Synovial tissue inflammation in early and late osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

The role of cytokines in osteoarthritis pathophysiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Evidence that rheumatoid arthritis synovial T cells are similar to cytokine-activated T cells: involvement of phosphatidylinositol 3-kinase and nuclear factor kappaB pathways in tumor necrosis factor alpha production in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Rapid isolation of total RNA from small samples of hypocellular, dense connective tissues.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

25 September 2018

Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1794533

15 November 2018

CD45-induced tumor necrosis factor alpha production in monocytes is phosphatidylinositol 3-kinase-dependent and nuclear factor-kappaB-independent

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Usefulness of high resolution US in the evaluation of effusion in osteoarthritic first carpometacarpal joint

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: a multicenter study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High resolution ultrasonography in detection of bone erosions in patients with hand osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of anti-TNF therapy for rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-reactive protein as a biomarker of emergent osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneous requirement of IkappaB kinase 2 for inflammatory cytokine and matrix metalloproteinase production in rheumatoid arthritis: implications for therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation and angiogenesis in osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine production in culture by cells isolated from the synovial membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: The Johnston county osteoarthritis project

1 reference

https://pubmed.ncbi.nlm.nih.gov/17177994

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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Europe PubMed Central

9 August 2017

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1 reference

Europe PubMed Central

9 August 2017

1 reference

Europe PubMed Central

9 August 2017

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