(Q35635340)

9 August 2017

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title

The 14-3-3 cancer connection (English)

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9 August 2017

Heiko Hermeking

1

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9 August 2017

language of work or name

English

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publication date

1 December 2003

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9 August 2017

published in

Nature Reviews Cancer

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9 August 2017

volume

3

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9 August 2017

issue

12

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9 August 2017

page(s)

931-943

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https://scigraph.springernature.com/pub.10.1038/nrc1230

9 August 2017

exact match

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cites work

14-3-3 proteins: a highly conserved, widespread family of eukaryotic proteins

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Molecular evolution of the 14-3-3 protein family

31 March 2020

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Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

31 March 2020

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The structural basis for 14-3-3:phosphopeptide binding specificity

31 March 2020

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14-3-3 proteins: key regulators of cell division, signalling and apoptosis.

31 March 2020

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Specificity of 14-3-3 isoform dimer interactions and phosphorylation

31 March 2020

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14-3-3 proteins: structure, function, and regulation

31 March 2020

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SH2 domains, interaction modules and cellular wiring

31 March 2020

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Involvement of 14-3-3 proteins in nuclear localization of telomerase

31 March 2020

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14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules

31 March 2020

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Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways

31 March 2020

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Crystal structure of the zeta isoform of the 14-3-3 protein

31 March 2020

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Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation

31 March 2020

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14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation

31 March 2020

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How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis

31 March 2020

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A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

31 March 2020

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A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.

31 March 2020

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

31 March 2020

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

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Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

31 March 2020

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Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding

31 March 2020

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Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import

31 March 2020

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DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding

31 March 2020

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Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25.

31 March 2020

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14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

31 March 2020

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14-3-3 proteins: regulation of subcellular localization by molecular interference

31 March 2020

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Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization

31 March 2020

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CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression

31 March 2020

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Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins

31 March 2020

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TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

31 March 2020

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Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways

31 March 2020

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

31 March 2020

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

31 March 2020

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Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif

31 March 2020

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14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner

31 March 2020

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Cdc25B activity is regulated by 14-3-3.

31 March 2020

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Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

31 March 2020

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Bcr and Raf form a complex in vivo via 14-3-3 proteins

31 March 2020

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14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation

31 March 2020

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Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein Phosphatases

31 March 2020

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14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome

31 March 2020

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Consummating signal transduction: the role of 14-3-3 proteins in the completion of signal-induced transitions in protein activity.

31 March 2020

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Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding

31 March 2020

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The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface

31 March 2020

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Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding

31 March 2020

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A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein

31 March 2020

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Identification of 14-3-3zeta as a protein kinase B/Akt substrate

31 March 2020

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Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth

31 March 2020

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

31 March 2020

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31 March 2020

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31 March 2020

Surfing the p53 network

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Checking out the G(2)/M transition.

31 March 2020

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Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.

31 March 2020

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Dual phosphorylation controls Cdc25 phosphatases and mitotic entry

31 March 2020

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Phosphorylation of Xenopus Cdc25C at Ser285 Interferes with Ability to Activate a DNA Damage Replication Checkpoint in the Pre-Midblastula Embryos

31 March 2020

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Regulation of CDC25B phosphatases subcellular localization

31 March 2020

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Positive regulation of Wee1 by Chk1 and 14-3-3 proteins

31 March 2020

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14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast

31 March 2020

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

31 March 2020

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The DNA damage response: putting checkpoints in perspective

31 March 2020

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

31 March 2020

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Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345

31 March 2020

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Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression

31 March 2020

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14-3-3σ Positively Regulates p53 and Suppresses Tumor Growth

31 March 2020

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

31 March 2020

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A matter of life and death

31 March 2020

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The Bcl2 family: regulators of the cellular life-or-death switch

31 March 2020

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BCL-2 family members and the mitochondria in apoptosis

31 March 2020

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

31 March 2020

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Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

31 March 2020

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

31 March 2020

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

31 March 2020

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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

31 March 2020

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Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery

31 March 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

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Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

31 March 2020

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14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

31 March 2020

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The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax

31 March 2020

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The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations

31 March 2020

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BRCA1 is a selective co-activator of 14-3-3 sigma gene transcription in mouse embryonic stem cells

31 March 2020

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

31 March 2020

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Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability

31 March 2020

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p63 identifies keratinocyte stem cells

31 March 2020

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Stem-cell hierarchy in skin cancer

31 March 2020

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Contribution of stem cells and differentiated cells to epidermal tumours

31 March 2020

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Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes

31 March 2020

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Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

31 March 2020

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Role of the beta isoform of 14-3-3 proteins in cellular proliferation and oncogenic transformation

31 March 2020

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Forced expression of antisense 14-3-3beta RNA suppresses tumor cell growth in vitro and in vivo

31 March 2020

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Tenascin-C signaling through induction of 14-3-3 tau.

31 March 2020

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Identification of genes overexpressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis

31 March 2020

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High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer

31 March 2020

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Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma

31 March 2020

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Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers

31 March 2020

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Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulval squamous neoplasia

31 March 2020

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Analysis of 14-3-3sigma expression in hyperproliferative skin diseases reveals selective loss associated with CpG-methylation in basal cell carcinoma

31 March 2020

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Decreased expression of 14-3-3sigma in neuroendocrine tumors is independent of origin and malignant potential.

31 March 2020

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Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer

31 March 2020

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Methylation and silencing of the retinoic acid receptor-beta 2 gene in cervical cancer

31 March 2020

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DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

31 March 2020

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Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.

31 March 2020

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DNA methylation, chromatin inheritance, and cancer

31 March 2020

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The fundamental role of epigenetic events in cancer

31 March 2020

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PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer.

31 March 2020

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The power and the promise of DNA methylation markers

31 March 2020

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Smart drugs: tyrosine kinase inhibitors in cancer therapy

31 March 2020

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The MYC oncogene as a cancer drug target

31 March 2020

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Perspectives on the development of a molecularly targeted agent

31 March 2020

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Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner

31 March 2020

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14-3-3 proteins block apoptosis and differentially regulate MAPK cascades

31 March 2020

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Survival-promoting functions of 14-3-3 proteins

31 March 2020

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Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display

31 March 2020

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Structural view of a fungal toxin acting on a 14-3-3 regulatory complex

31 March 2020

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

31 March 2020

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Structural basis for Chk1 inhibition by UCN-01

31 March 2020

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

31 March 2020

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UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

31 March 2020

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Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms

31 March 2020

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Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo

31 March 2020

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Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1230

1 reference

9 August 2017

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