(Q35642602)

9 August 2017

Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides (English)

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9 August 2017

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1

Arthur M Krieg

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9 August 2017

1 March 2004

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9 August 2017

Current Oncology Reports

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9 August 2017

6

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9 August 2017

88-95

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9 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s11912-004-0019-0

9 August 2017

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1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

CpG motifs in bacterial DNA and their immune effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

CpG motifs in bacterial DNA trigger direct B-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Immunostimulatory DNA pre-priming: a novel approach for prolonged Th1-biased immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

IFN-gamma-inducible protein-10 is essential for the generation of a protective tumor-specific CD8 T cell response induced by single-chain IL-12 gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

The functional role of the ELR motif in CXC chemokine-mediated angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Peritumoral CpG DNA elicits a coordinated response of CD8 T cells and innate effectors to cure established tumors in a murine colon carcinoma model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

NK- and CD8(+) T cell-mediated eradication of established tumors by peritumoral injection of CpG-containing oligodeoxynucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Intratumor CpG-Oligodeoxynucleotide Injection Induces Protective Antitumor T Cell Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Synthetic unmethylated cytosine-phosphate-guanosine oligodeoxynucleotides are potent stimulators of antileukemia responses in naive and bone marrow transplant recipients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Role of Toll-like receptors in costimulating cytotoxic T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Established human papillomavirus type 16-expressing tumors are effectively eradicated following vaccination with long peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Effect of immunological adjuvant combinations on the antibody and T-cell response to vaccination with MUC1-KLH and GD3-KLH conjugates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Combined dendritic cell- and CpG oligonucleotide-based immune therapy cures large murine tumors that resist chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Vaccination with tumor peptide in CpG adjuvant protects via IFN-gamma-dependent CD4 cell immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

CpG-oligonucleotides for cancer immunotherapy : review of the literature and potential applications in malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

CpG motifs: the active ingredient in bacterial extracts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11912-004-0019-0

CpG oligodeoxynucleotides enhance monoclonal antibody therapy of a murine lymphoma

21 January 2018

1 reference

12 December 2020

CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses

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12 December 2020

CpG-A-induced monocyte IFN-gamma-inducible protein-10 production is regulated by plasmacytoid dendritic cell-derived IFN-alpha

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12 December 2020

Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade.

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12 December 2020

Priming MHC-I-restricted cytotoxic T lymphocyte responses to exogenous hepatitis B surface antigen is CD4+ T cell dependent

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12 December 2020

Immune-mediated tumor regression induced by CpG-containing oligodeoxynucleotides

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12 December 2020

Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells

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12 December 2020

The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor.

1 reference

12 December 2020

A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant

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12 December 2020

Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma

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12 December 2020

CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL.

1 reference

12 December 2020

CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma

1 reference

12 December 2020

Plasmacytoid dendritic cell-derived IFN-alpha induces TNF-related apoptosis-inducing ligand/Apo-2L-mediated antitumor activity by human monocytes following CpG oligodeoxynucleotide stimulation

1 reference

12 December 2020

Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12

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12 December 2020

Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocyte-macrophage colony-stimulating factor

1 reference

12 December 2020

Oligodeoxynucleotides containing CpG motifs can induce rejection of a neuroblastoma in mice

1 reference

12 December 2020

Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins

1 reference

12 December 2020

Sensitization of B-cell chronic lymphocytic leukemia cells to recombinant immunotoxin by immunostimulatory phosphorothioate oligodeoxynucleotides.

1 reference

12 December 2020

Both E7 and CpG-oligodeoxynucleotide are required for protective immunity against challenge with human papillomavirus 16 (E6/E7) immortalized tumor cells: involvement of CD4+ and CD8+ T cells in protection.

1 reference

12 December 2020

Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer

1 reference

12 December 2020

Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN

1 reference

12 December 2020

CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry.

1 reference

12 December 2020

CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma.

1 reference

12 December 2020

CpG DNA increases primary malignant B cell expression of costimulatory molecules and target antigens

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12 December 2020

Use of CpG DNA for enhancing specific immune responses.

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12 December 2020

CpG are efficient adjuvants for specific CTL induction against tumor antigen-derived peptide

1 reference

12 December 2020

CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants

1 reference

12 December 2020

APC stimulated by CpG oligodeoxynucleotide enhance activation of MHC class I-restricted T cells

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12 December 2020

Eradication of disseminated lymphomas with CpG-DNA activated T helper type 1 cells from nontransgenic mice

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12 December 2020

10.1007/S11912-004-0019-0

Identifiers

DOI

1 reference

9 August 2017

1 reference

PubMed ID

14751085