(Q35644191)

9 August 2017

title

A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma (English)

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9 August 2017

main subject

phase I clinical trial

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1 reference

Giselle L Saulnier Sholler

1

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9 August 2017

Eugene W Gerner

2

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9 August 2017

Genevieve Bergendahl

3

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9 August 2017

Robert B MacArthur

4

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9 August 2017

Alyssa VanderWerff

5

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9 August 2017

Takamaru Ashikaga

6

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9 August 2017

Jeffrey P Bond

7

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9 August 2017

William Ferguson

8

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9 August 2017

William Roberts

9

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9 August 2017

Randal K Wada

10

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9 August 2017

Don Eslin

11

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9 August 2017

Jacqueline M Kraveka

12

1 reference

9 August 2017

Joel Kaplan

13

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9 August 2017

Deanna Mitchell

14

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9 August 2017

Nehal S Parikh

15

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9 August 2017

Kathleen Neville

16

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9 August 2017

Leonard Sender

17

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9 August 2017

Timothy Higgins

18

1 reference

9 August 2017

Masao Kawakita

19

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9 August 2017

Kyoko Hiramatsu

20

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9 August 2017

Shun-Suke Moriya

21

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9 August 2017

André S Bachmann

22

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9 August 2017

language of work or name

English

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publication date

27 May 2015

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9 August 2017

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9 August 2017

volume

10

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9 August 2017

issue

5

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9 August 2017

page(s)

e0127246

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Creative Commons Attribution 4.0 International

9 August 2017

copyright license

start time

27 May 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation

12 July 2018

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AMXT-1501, a novel polyamine transport inhibitor, synergizes with DFMO in inhibiting neuroblastoma cell proliferation by targeting both ornithine decarboxylase and polyamine transport

12 July 2018

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DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma

12 July 2018

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12 July 2018

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Levels of rectal mucosal polyamines and prostaglandin E2 predict ability of DFMO and sulindac to prevent colorectal adenoma

12 July 2018

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12 July 2018

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12 July 2018

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The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma

12 July 2018

1 reference

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Ornithine decarboxylase inhibition by alpha-difluoromethylornithine activates opposing signaling pathways via phosphorylation of both Akt/protein kinase B and p27Kip1 in neuroblastoma

12 July 2018

1 reference

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ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells

12 July 2018

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12 July 2018

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12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446210

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene

12 July 2018

1 reference

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12 July 2018

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Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446210

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12 July 2018

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Ornithine decarboxylase activity is critical for cell transformation

12 July 2018

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A Phase 1 Trial of TPI 287 as a Single Agent and in Combination With Temozolomide in Patients with Refractory or Recurrent Neuroblastoma or Medulloblastoma

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446210

Recent advances in neuroblastoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4446210

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25 September 2018

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25 September 2018

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Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0127246

Determination of N¹,N¹²-diacetylspermine in urine: a novel tumor marker

21 January 2018

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12 December 2020

Polyamine accumulation and biosynthesis in a mouse L1210 leukemia

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12 December 2020

Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines

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Bioavailability study of oral liquid and tablet forms of alpha-difluoromethylornithine

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12 December 2020

Urinary and erythrocyte polyamines during the evaluation of oral alpha-difluoromethylornithine in a phase I chemoprevention clinical trial

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Characterization of a Diamine Exporter in Chinese Hamster Ovary Cells and Identification of Specific Polyamine Substrates

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12 December 2020

10.1371/JOURNAL.PONE.0127246

Identifiers

DOI

1 reference

9 August 2017

0 references

1 reference

9 August 2017

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