(Q35660234)

9 August 2017

title

The Lymphocyte Potassium Channels Kv1.3 and KCa3.1 as Targets for Immunosuppression (English)

1 reference

9 August 2017

1 reference

Jenny Lam

1

1 reference

9 August 2017

Heike Wulff

series ordinal

2

1 reference

9 August 2017

publication date

1 November 2011

1 reference

Drug Development Research

9 August 2017

published in

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9 August 2017

volume

72

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9 August 2017

issue

7

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9 August 2017

page(s)

573-584

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Therapeutic potential of KCa3.1 blockers: recent advances and promising trends

9 August 2017

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1 reference

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Inhibition of the K+ channel KCa3.1 ameliorates T cell-mediated colitis

27 July 2018

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27 July 2018

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27 July 2018

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The K+ channels K(Ca)3.1 and K(v)1.3 as novel targets for asthma therapy

27 July 2018

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Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery

27 July 2018

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Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

27 July 2018

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Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes

27 July 2018

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27 July 2018

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The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans

27 July 2018

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KCa3.1: target and marker for cancer, autoimmune disorder and vascular inflammation?

27 July 2018

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Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques

27 July 2018

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Targeting effector memory T-cells with Kv1.3 blockers

27 July 2018

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Modulators of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels and their Therapeutic Indications

27 July 2018

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Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Functional KCa3.1 K+ channels are required for human lung mast cell migration

27 July 2018

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A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone

27 July 2018

1 reference

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Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Extracellular ATP induces oscillations of intracellular Ca2+ and membrane potential and promotes transcription of IL-6 in macrophages.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Functional importance of Ca2+-activated K+ channels for lysophosphatidic acid-induced microglial migration

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Immunopathogenic mechanisms in psoriasis.

27 July 2018

1 reference

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Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Benzamide derivatives as blockers of Kv1.3 ion channel

27 July 2018

1 reference

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CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking.

27 July 2018

1 reference

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Regulation of Kv1 subunit expression in oligodendrocyte progenitor cells and their role in G1/S phase progression of the cell cycle

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

K+ channels and the microglial respiratory burst

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

The fibroblast intermediate conductance K(Ca) channel, FIK, as a prototype for the cell growth regulatory function of the IK channel family

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Molecular cloning and characterization of the intermediate-conductance Ca(2+)-activated K(+) channel in vascular smooth muscle: relationship between K(Ca) channel diversity and smooth muscle cell function

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Modulation of olfactory bulb neuron potassium current by tyrosine phosphorylation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

hSK4, a member of a novel subfamily of calcium-activated potassium channels

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

WIN 17317-3: novel nonpeptide antagonist of voltage-activated K+ channels in human T lymphocytes.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Clotrimazole in rheumatoid arthritis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Ca2(+)-activated K+ channels in human B lymphocytes and rat thymocytes.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Expression and chromosomal localization of a lymphocyte K+ channel gene

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Basolateral K+ channels in airway epithelia. I. Regulation by Ca2+ and block by charybdotoxin

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Dose-escalation study of ICA-17043 in patients with sickle cell disease.

27 July 2018

1 reference

Improvements in haemolysis and indicators of erythrocyte survival do not correlate with acute vaso-occlusive crises in patients with sickle cell disease: a phase III randomized, placebo-controlled, double-blind study of the Gardos channel blocker se

21 January 2018

1 reference

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

21 January 2018

1 reference

Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4.

21 January 2018

1 reference

Maurotoxin: a potent inhibitor of intermediate conductance Ca2+-activated potassium channels.

21 January 2018

1 reference

K+ channels as targets for specific immunomodulation

21 January 2018

1 reference

Resting and activation-dependent ion channels in human mast cells

21 January 2018

1 reference

The K+ channel iKCA1 potentiates Ca2+ influx and degranulation in human lung mast cells

21 January 2018

1 reference

The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model.

21 January 2018

1 reference

Disruption of the Gardos channel (KCa3.1) in mice causes subtle erythrocyte macrocytosis and progressive splenomegaly.

21 January 2018

1 reference

UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation

21 January 2018

1 reference

Voltage-gated potassium channel Kv1.3 blocker as a potential treatment for rat anti-glomerular basement membrane glomerulonephritis

21 January 2018

1 reference

The Ca2+-activated K+ channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration

21 January 2018

1 reference

Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels.

21 January 2018

1 reference

Expression of CCR7 in multiple sclerosis: implications for CNS immunity

21 January 2018

1 reference

The immunopathology of multiple sclerosis: an overview

21 January 2018

1 reference

Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity

21 January 2018

1 reference

A patch-clamp study of mammalian platelets and their voltage-gated potassium current

21 January 2018

1 reference

Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block

21 January 2018

1 reference

21 January 2018

1 reference

Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties

21 January 2018

1 reference

KCa3.1 Ca2+ activated K+ channels regulate human airway smooth muscle proliferation.

21 January 2018

1 reference

Blunted IgE-mediated activation of mast cells in mice lacking the Ca2+-activated K+ channel KCa3.1.

21 January 2018

1 reference

Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+ channel.

21 January 2018

1 reference

KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population

21 January 2018

1 reference

Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis.

21 January 2018

1 reference

Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages

21 January 2018

1 reference

The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS

21 January 2018

1 reference

K+ channel expression during B cell differentiation: implications for immunomodulation and autoimmunity

21 January 2018

1 reference

Blockers of voltage-gated K channels inhibit proliferation of cultured brown fat cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3253536

25 September 2018

1 reference

Allergic contact dermatitis

21 January 2018

1 reference

12 December 2020

Mammalian osteoclasts express a transient potassium channel with properties of Kv1.3.

1 reference

12 December 2020

Novel inhibitors of potassium ion channels on human T lymphocytes

1 reference

12 December 2020

Binding of correolide to K(v)1 family potassium channels. Mapping the domains of high affinity interaction

1 reference

12 December 2020

Kv1.3 potassium channels in human alveolar macrophages

1 reference

12 December 2020

Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia

1 reference

12 December 2020

Ras/MEK/ERK Up-regulation of the fibroblast KCa channel FIK is a common mechanism for basic fibroblast growth factor and transforming growth factor-beta suppression of myogenesis

1 reference

12 December 2020

Multiple sclerosis: a two-stage disease

1 reference

12 December 2020

Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice

1 reference

12 December 2020

Differential regulation of voltage- and calcium-activated potassium channels in human B lymphocytes

1 reference

12 December 2020

Properties of K+ and Cl- channels and their involvement in proliferation of rat microglial cells

1 reference

12 December 2020

Potent nor-triterpenoid blockers of the voltage-gated potassium channel Kv1.3 from Spachea correae

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/DDR.20467

1 reference

9 August 2017

1 reference

9 August 2017

1 reference