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Molecular insights into regulation of JAK2 in myeloproliferative neoplasms
scientific article published on 30 March 2015
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scholarly article
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Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
review article
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Europe PubMed Central
title
Molecular insights into regulation of JAK2 in myeloproliferative neoplasms
(English)
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stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
author
Stevan R Hubbard
series ordinal
2
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Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
author name string
Olli Silvennoinen
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
language of work or name
English
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publication date
30 March 2015
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Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
published in
Blood
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stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
volume
125
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stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
issue
22
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
page(s)
3388-3392
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
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PubMed Central
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The molecular regulation of Janus kinase (JAK) activation
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Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
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The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
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12 July 2018
The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.
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12 July 2018
JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors
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Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling
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JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
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12 July 2018
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12 July 2018
Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling
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12 July 2018
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12 July 2018
Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
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12 July 2018
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
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12 July 2018
A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-alpha signaling
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12 July 2018
Regulation of the Jak2 tyrosine kinase by its pseudokinase domain
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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12 July 2018
Complex effects of naturally occurring mutations in the JAK3 pseudokinase domain: evidence for interactions between the kinase and pseudokinase domains
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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12 July 2018
The Jak-Stat pathway in normal and perturbed hematopoiesis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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12 July 2018
Jak2 is essential for signaling through a variety of cytokine receptors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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12 July 2018
Structural and functional basis for JAK3-deficient severe combined immunodeficiency
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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12 July 2018
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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12 July 2018
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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12 July 2018
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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12 July 2018
An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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12 July 2018
From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
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25 September 2018
Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447858
retrieved
25 September 2018
Identifiers
DOI
10.1182/BLOOD-2015-01-621110
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PMC publication ID
4447858
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
PubMed publication ID
25824690
1 reference
stated in
Europe PubMed Central
PMC publication ID
4447858
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25824690%20AND%20SRC:MED&resulttype=core&format=json
retrieved
4 March 2020
ResearchGate publication ID
274319428
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