(Q35688457)

English

UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP.

scientific article published on 9 November 2011

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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1 reference

based on heuristic

inferred from title

author name string

Wen Jiang

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Beibei Xu

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Baojian Wu

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Rong Yu

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Ming Hu

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

publication date

9 November 2011

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

40

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

336-345

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

describes a project that uses

0 references

Specific inhibitors of the breast cancer resistance protein (BCRP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

12 July 2018

Breast cancer resistance protein (BCRP) and sulfotransferases contribute significantly to the disposition of genistein in mouse intestine

1 reference

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12 July 2018

Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes

1 reference

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12 July 2018

Interplay of transporters and enzymes in drug and metabolite processing.

1 reference

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12 July 2018

Sex-dependent disposition of acetaminophen sulfate and glucuronide in the in situ perfused mouse liver.

1 reference

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Flavonoids, vascular function and cardiovascular protection

1 reference

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Effect of flavonoids on human health: old subjects but new challenges.

1 reference

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Metabolism and transport of the citrus flavonoid hesperetin in Caco-2 cell monolayers

1 reference

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Identification of the transporters involved in the hepatobiliary transport and intestinal efflux of methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) glucuronide, a pharmacologically active metabolite

1 reference

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12 July 2018

Glucuronidation of the soyabean isoflavones genistein and daidzein by human liver is related to levels of UGT1A1 and UGT1A9 activity and alters isoflavone response in the MCF-7 human breast cancer cell line

1 reference

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12 July 2018

Beneficial action of Citrus flavonoids on multiple cancer-related biological pathways.

1 reference

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Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

1 reference

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12 July 2018

Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA.

1 reference

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Modulation of sinusoidal and canalicular elimination of bilirubin-glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes

1 reference

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Natural polyphenol disposition via coupled metabolic pathways

1 reference

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Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

12 July 2018

Regional expression and activity of breast cancer resistance protein (Bcrp/Abcg2) in mouse intestine: overlapping distribution with sulfotransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

12 July 2018

Effects of coexpression of UGT1A9 on enzymatic activities of human UGT1A isoforms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

12 July 2018

Interaction of the breast cancer resistance protein with plant polyphenols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

12 July 2018

Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

12 July 2018

Atypical kinetic profiles in drug metabolism reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

12 July 2018

Secretory mechanisms of grepafloxacin and levofloxacin in the human intestinal cell line caco-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

12 July 2018

In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model

1 reference

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12 July 2018

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

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Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

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Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

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Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs

1 reference

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Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

25 September 2018

Permeability, transport, and metabolism of solutes in Caco-2 cell monolayers: a theoretical study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

25 September 2018

Disposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic properties.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

25 September 2018

In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway

1 reference

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25 September 2018

Modulation of breast cancer resistance protein (BCRP/ABCG2) gene expression using RNA interference.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

25 September 2018

Influence of genetic variants in UGT1A1 and UGT1A9 on the in vivo glucuronidation of SN-38.

1 reference

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25 September 2018

Metabolism of flavonoids via enteric recycling: mechanistic studies of disposition of apigenin in the Caco-2 cell culture model

1 reference

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25 September 2018

Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.

1 reference

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25 September 2018

Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

25 September 2018

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3263940

25 September 2018

Transport of 7-ethyl-10-hydroxycamptothecin (SN-38) by breast cancer resistance protein ABCG2 in human lung cancer cells

1 reference

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Mechanisms of gentamicin transport in kidney epithelial cell line (LLC-PK1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22071170

12 December 2020

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Identifiers

10.1124/DMD.111.041467

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

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