(Q35690886)

9 August 2017

1 reference

title

Metabolism of valproate to hepatotoxic intermediates (English)

1 reference

9 August 2017

1 reference

T A Baillie

1

1 reference

9 August 2017

publication date

1 June 1992

1 reference

Pharmaceutisch weekblad. Scientific edition

9 August 2017

published in

1 reference

9 August 2017

volume

14

1 reference

9 August 2017

issue

3A

1 reference

9 August 2017

page(s)

122-125

1 reference

Valproate-associated hepatotoxicity and its biochemical mechanisms

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FBF01962701

Valproic acid hepatic fatalities: a retrospective review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01962701

Valproate-induced hepatic steatogenesis in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01962701

The enzymatic basis for the metabolism and inhibitory effects of valproic acid: dehydrogenation of valproyl-CoA by 2-methyl-branched-chain acyl-CoA dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01962701

Carnitine deficiency, organic acidemias, and Reye's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF01962701

Cytochrome P-450--catalyzed formation of delta 4-VPA, a toxic metabolite of valproic acid

21 January 2018

1 reference

12 December 2020

Reye-like syndrome associated with valproic acid therapy

1 reference

12 December 2020

Metabolism of 4-pentenoic acid and inhibition of thiolase by metabolites of 4-pentenoic acid

1 reference

12 December 2020

The hepatotoxicity of valproic acid and its metabolites in rats. II. Intermediary and valproic acid metabolism

1 reference

12 December 2020

Influence of valproic acid on hepatic carbohydrate and lipid metabolism

1 reference

12 December 2020

Abnormal metabolism of valproic acid in fatal hepatic failure

1 reference

12 December 2020

Inhibition of fatty acid oxidation by valproate

1 reference

12 December 2020

Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid

1 reference

12 December 2020

Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid

1 reference

12 December 2020

Metabolism of branched medium chain length fatty acid. II--beta-oxidation of sodium dipropylacetate in rats

1 reference

12 December 2020

Inhibition of medium-chain fatty acid beta-oxidation in vitro by valproic acid and its unsaturated metabolite, 2-n-propyl-4-pentenoic acid

1 reference

12 December 2020

Early structural and functional changes in liver of rats treated with a single dose of valproic acid

1 reference

12 December 2020

Metabolism of unsaturated derivatives of valproic acid in rat liver microsomes and destruction of cytochrome P-450.

1 reference

12 December 2020

Metabolic activation of valproic acid and drug-mediated hepatotoxicity. Role of the terminal olefin, 2-n-propyl-4-pentenoic acid

1 reference

12 December 2020

Aspects of the metabolism of valproic acid

1 reference

12 December 2020

Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry

1 reference

12 December 2020

Valproate-induced hepatic injury: analyses of 23 fatal cases

1 reference

12 December 2020

Studies on the biotransformation in the perfused rat liver of 2-n-propyl-4-pentenoic acid, a metabolite of the antiepileptic drug valproic acid. Evidence for the formation of chemically reactive intermediates

1 reference

12 December 2020

The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopathologic studies

1 reference

12 December 2020

Sodium valproate in the induction of unusual hepatotoxicity

1 reference

12 December 2020

Biotransformation and pharmacokinetics in the rhesus monkey of 2-n-propyl-4-pentenoic acid, a toxic metabolite of valproic acid

1 reference

12 December 2020

The covalent binding to protein of valproic acid and its hepatotoxic metabolite, 2-n-propyl-4-pentenoic acid, in rats and in isolated rat hepatocytes.

1 reference

12 December 2020

A single therapeutic dose of valproate affects liver carbohydrate, fat, adenylate, amino acid, coenzyme A, and carnitine metabolism in infant mice: possible clinical significance.

1 reference

12 December 2020

Hepatic hydrolysis of octanoyl-CoA and valproyl-CoA in control and valproate-fed animals

1 reference

12 December 2020

The toxicity of metabolites of sodium valproate in cultured hepatocytes

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF01962701

1 reference

9 August 2017

1 reference