(Q35691555)

9 August 2017

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title

Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases (English)

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9 August 2017

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Mina D Marmor

1

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9 August 2017

Yosef Yarden

series ordinal

2

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9 August 2017

language of work or name

English

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publication date

1 March 2004

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9 August 2017

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9 August 2017

volume

23

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9 August 2017

issue

11

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9 August 2017

page(s)

2057-2070

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Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

AP-2/Eps15 interaction is required for receptor-mediated endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Oncogenic kinase signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Ubiquitin-independent entry into the yeast recycling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Hrs interacts with sorting nexin 1 and regulates degradation of epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Multiple sorting pathways between the late Golgi and the vacuole in yeast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Phosphoinositides as regulators in membrane traffic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Endocytosis and mitogenic signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

When ubiquitin meets ubiquitin receptors: a signalling connection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Negative receptor signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Vps9, Rabex-5 and DSS4: proteins with weak but distinct nucleotide-exchange activities for Rab proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Cbl-b-dependent coordinated degradation of the epidermal growth factor receptor signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Di-leucine-mediated internalization of ligand by a truncated growth hormone receptor is independent of the ubiquitin conjugation system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Early endosomal localization of hrs requires a sequence within the proline- and glutamine-rich region but not the FYVE finger

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Recognition of sorting signals by clathrin adaptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

1 reference

7 January 2021

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Receptor downregulation and multivesicular-body sorting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Vps27 recruits ESCRT machinery to endosomes during MVB sorting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Hrs and hbp: possible regulators of endocytosis and exocytosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Multiple truncated transcripts of TSG101 in gastrointestinal cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Overexpression of tumor susceptibility gene TSG101 in human papillary thyroid carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Proteolysis and the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Agonist-promoted ubiquitination of the G protein-coupled receptor CXCR4 mediates lysosomal sorting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

mGrb10 interacts with Nedd4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Endocytosis of Receptor Tyrosine Kinases Is Driven by Monoubiquitylation, Not Polyubiquitylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

c-Cbl is a critical modulator of the Ron tyrosine kinase receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Structure and functional interactions of the Tsg101 UEV domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Mechanisms of enveloped RNA virus budding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

1 reference

7 January 2021

Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

The role of ubiquitylation in signaling by growth factors: implications to cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

The yeast Npi1/Rsp5 ubiquitin ligase lacking its N-terminal C2 domain is competent for ubiquitination but not for subsequent endocytosis of the gap1 permease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

A hrs binding protein having a Src homology 3 domain is involved in intracellular degradation of growth factors and their receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Cbl: many adaptations to regulate protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Beyond the RING: CBL proteins as multivalent adapters

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Ligand-induced transformation by a noninternalizing epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Regulation of receptor tyrosine kinase signaling by endocytic trafficking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Untangling the ErbB signalling network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207390

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207390

1 reference

9 August 2017

1 reference