(Q35693895)

9 August 2017

title

Cardiac deficiency of single cytochrome oxidase assembly factor scox induces p53-dependent apoptosis in a Drosophila cardiomyopathy model (English)

1 reference

9 August 2017

0 references

1 reference

Leticia Martínez-Morentin

1

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9 August 2017

Lidia Martínez

2

1 reference

9 August 2017

Sarah Piloto

3

1 reference

9 August 2017

Hua Yang

4

1 reference

9 August 2017

Eric A Schon

5

1 reference

9 August 2017

Rafael Garesse

6

1 reference

9 August 2017

Rolf Bodmer

7

1 reference

9 August 2017

Karen Ocorr

8

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9 August 2017

Margarita Cervera

9

1 reference

9 August 2017

Juan J Arredondo

10

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9 August 2017

publication date

19 March 2015

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9 August 2017

published in

Human Molecular Genetics

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9 August 2017

volume

24

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9 August 2017

issue

13

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9 August 2017

page(s)

3608-3622

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Mitophagy and heart failure

9 August 2017

cites work

1 reference

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Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart

27 July 2018

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Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability

27 July 2018

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27 July 2018

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Muscle mitohormesis promotes longevity via systemic repression of insulin signaling

27 July 2018

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Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity

27 July 2018

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Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

27 July 2018

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27 July 2018

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SCO2 induces p53-mediated apoptosis by Thr845 phosphorylation of ASK-1 and dissociation of the ASK-1-Trx complex.

27 July 2018

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Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis

27 July 2018

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27 July 2018

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The many clinical faces of cytochrome c oxidase deficiency

27 July 2018

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p53 opens the mitochondrial permeability transition pore to trigger necrosis

27 July 2018

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Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function

27 July 2018

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Properties of Ca(2+) transport in mitochondria of Drosophila melanogaster

27 July 2018

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Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core

27 July 2018

1 reference

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Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

27 July 2018

1 reference

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Drosophila, genetic screens, and cardiac function

27 July 2018

1 reference

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Neonatal cardiomyopathies and metabolic crises due to oxidative phosphorylation defects

27 July 2018

1 reference

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MARF and Opa1 control mitochondrial and cardiac function in Drosophila

27 July 2018

1 reference

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Mitochondrial respiration protects against oxygen-associated DNA damage

27 July 2018

1 reference

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Mitochondrial involvement in cell death of non-mammalian eukaryotes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Dual roles of Drosophila p53 in cell death and cell differentiation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Heterozygous mutation of Drosophila Opa1 causes the development of multiple organ abnormalities in an age-dependent and organ-specific manner

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

p53 improves aerobic exercise capacity and augments skeletal muscle mitochondrial DNA content

27 July 2018

1 reference

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p53 regulates mtDNA copy number and mitocheckpoint pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Blinded by the Light: The Growing Complexity of p53

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Loss of function of Sco1 and its interaction with cytochrome c oxidase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense

27 July 2018

1 reference

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Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease

27 July 2018

1 reference

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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Genetic control of heart function and aging in Drosophila

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

The human cytochrome c oxidase assembly factors SCO1 and SCO2 have regulatory roles in the maintenance of cellular copper homeostasis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Regulation of AIF expression by p53.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

p53 regulates mitochondrial respiration

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Lack of involvement of mitochondrial factors in caspase activation in a Drosophila cell-free system

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Post-transcriptional silencing and functional characterization of the Drosophila melanogaster homolog of human Surf1.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Human Sco1 and Sco2 function as copper-binding proteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase "assembly" protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

The epidemiology of mitochondrial disorders--past, present and future

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Cell death: critical control points

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Topology of superoxide production from different sites in the mitochondrial electron transport chain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase, Yno1p, in yeast

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Novel mutations in SCO1 as a cause of fatal infantile encephalopathy and lactic acidosis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Crosstalk between apoptosis, necrosis and autophagy

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Drosophila type XV/XVIII collagen mutants manifest integrin mediated mitochondrial dysfunction, which is improved by cyclosporin A and losartan.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Mitochondrial cardioencephalomyopathy due to a novel SCO2 mutation in a Brazilian patient: case report and literature review

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Mitochondrial disruption in Drosophila apoptosis.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Mechanisms for increased glycolysis in the hypertrophied rat heart

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Association of mutations in SCO2, a cytochrome c oxidase assembly gene, with early fetal lethality

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Expression of baculovirus P35 prevents cell death in Drosophila

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4459388

Neonatal onset of mitochondrial disorders in 129 patients: clinical and laboratory characteristics and a new approach to diagnosis

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FHMG%2FDDV106

Failing mouse hearts utilize energy inefficiently and benefit from improved coupling of glycolysis and glucose oxidation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25792727

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25792727

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25792727

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDV106

1 reference

9 August 2017

1 reference

9 August 2017

1 reference