(Q35700595)

9 August 2017

title

Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. (English)

1 reference

9 August 2017

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A J Carter

1

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9 August 2017

M Grauert

2

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9 August 2017

U Pschorn

3

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9 August 2017

W D Bechtel

4

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9 August 2017

C Bartmann-Lindholm

5

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9 August 2017

Y Qu

6

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9 August 2017

T Scheuer

7

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9 August 2017

W A Catterall

8

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9 August 2017

T Weiser

9

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9 August 2017

language of work or name

English

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publication date

1 April 2000

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Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

published in

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9 August 2017

volume

97

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9 August 2017

issue

9

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9 August 2017

page(s)

4944-4949

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Glutamate in CNS disorders as a target for drug development: an update

9 August 2017

cites work

1 reference

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The changing landscape of ischaemic brain injury mechanisms.

27 July 2018

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27 July 2018

Neuroprotective therapy

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Interaction of batrachotoxin with the local anesthetic receptor site in transmembrane segment IVS6 of the voltage-gated sodium channel

27 July 2018

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Lysine point mutations in Na+ channel D4-S6 reduce inactivated channel block by local anesthetics

27 July 2018

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27 July 2018

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27 July 2018

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Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

27 July 2018

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Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination

27 July 2018

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27 July 2018

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Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine

27 July 2018

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27 July 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

27 July 2018

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Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles

27 July 2018

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Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

27 July 2018

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Rodent models of cerebral ischemia

27 July 2018

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The pathophysiology of anoxic injury in central nervous system white matter.

27 July 2018

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Dissociated cell culture of rat cerebral cortical neurons in serum-free, conditioned media: GABA-immunopositive neurons

27 July 2018

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New models of focal cerebral ischaemia

27 July 2018

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27 July 2018

Epidemiology of stroke

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Cellular and molecular biology of voltage-gated sodium channels

27 July 2018

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Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger.

27 July 2018

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

27 July 2018

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Rat hippocampal neurons in dispersed cell culture.

27 July 2018

1 reference

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Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

Differential interaction of R-mexiletine with the local anesthetic receptor site on brain and heart sodium channel alpha-subunits.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

BIIR 561 CL: a novel combined antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and voltage-dependent sodium channels with anticonvulsive and neuroprotective properties.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

The importance of voltage-dependent sodium channels in cerebral ischaemia.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as antagonists of the NMDA receptor-channel complex.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

State-dependent inhibition of Na+ currents by the neuroprotective agent 619C89 in rat hippocampal neurons and in a mammalian cell line expressing rat brain type IIA Na+ channels

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by local anesthetics

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

Reduction of glutamate release and protection against ischemic brain damage by BW 1003C87.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18337

The influence of repeated doses, route and time of administration on the neuroprotective effects of BIII 277 CL in a rat model of focal cerebral ischemia

25 September 2018

1 reference

12 December 2020

The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat

1 reference

12 December 2020

Many agents that antagonize the NMDA receptor-channel complex in vivo also cause disturbances of motor coordination

1 reference

12 December 2020

BIII 277 CL is a potent and specific ion-channel blocker of the NMDA receptor-channel complex

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.040577097

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9 August 2017

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9 August 2017

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