(Q35707934)

9 August 2017

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title

Quinoids formed from estrogens and antiestrogens (English)

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9 August 2017

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1

Judy L Bolton

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9 August 2017

Linning Yu

2

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9 August 2017

Gregory R J Thatcher

series ordinal

3

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9 August 2017

language of work or name

English

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publication date

1 January 2004

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9 August 2017

published in

Methods in Enzymology

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9 August 2017

volume

378

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9 August 2017

page(s)

110-123

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Genotoxic effects of estrogens

9 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Estrogens and breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Relationship between estrogen levels, use of hormone replacement therapy, and breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Understanding the genotoxicity of tamoxifen?

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

New role for estrogen in cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Role of quinoids in estrogen carcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

New Highly Stereoselective Synthesis of (Z)-4-Hydroxytamoxifen and (Z)-4-Hydroxytoremifene via McMurry Reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Derivatives of tamoxifen. Dependence of antiestrogenicity on the 4-substituent

1 reference

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7 January 2021

Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]-phenyl]methanone hydrochloride (LY156758), a remarkably

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

DNA damage as assessed by 32P-postlabelling in three rat strains exposed to dietary tamoxifen: the relationship between cell proliferation and liver tumour formation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended pi-conjugation dramatically stabilizes the quinone methide formed from eugenol

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Tamoxifen: evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Tamoxifen-DNA adducts detected in the endometrium of women treated with tamoxifen.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

DNA adducts formed from 4-hydroxytamoxifen are more mutagenic than those formed by alpha-acetoxytamoxifen in a shuttle vector target gene replicated in human Ad293 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Tamoxifen and toremifene in breast cancer: comparison of safety and efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Tamoxifen-associated eye disease. A review

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

p-Quinone methides are the major decomposition products of catechol estrogen o-quinones.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Synthesis and characterization of estrogen 2,3- and 3,4-quinones. Comparison of DNA adducts formed by the quinones versus horseradish peroxidase-activated catechol estrogens

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Molecular characteristics of catechol estrogen quinones in reactions with deoxyribonucleosides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Mutagenic specificity of model estrogen-DNA adducts in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Reactions of estradiol-2,3-quinone with deoxyribonucleosides: possible insights in the reactivity of estrogen quinones with DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Detection of estrogen DNA-adducts in human breast tumor tissue and healthy tissue by combined nano LC-nano ES tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Synergistic induction of DNA strand breakage by catechol-estrogen and nitric oxide: implications for hormonal carcinogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

In vitro generation of peroxynitrite by 2- and 4-hydroxyestrogens in the presence of nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Relative rates of 2- and 4-hydroxyestrogen synthesis are dependent on both substrate and tissue

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Role of quinones in toxicology.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Equilenin-2'-deoxynucleoside adducts: analysis with nano-liquid chromatography coupled to nano-electrospray tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

Equine estrogen metabolite 4-hydroxyequilenin induces DNA damage in the rat mammary tissues: formation of single-strand breaks, apurinic sites, stable adducts, and oxidized bases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2804%2978006-4

7 January 2021

10.1016/S0076-6879(04)78006-4

Identifiers

DOI

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9 August 2017

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