(Q35718576)

English

Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling

scientific article published on February 2012

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

Olaf Weber

1

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Stefan Willmann

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Hilmar Bischoff

3

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Volkhart Li

4

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Alexandros Vakalopoulos

5

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Klemens Lustig

6

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Frank-Thorsten Hafner

7

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Roland Heinig

8

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Carsten Schmeck

9

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Klaus Buehner

10

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

language of work or name

0 references

publication date

1 February 2012

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

British Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

73

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

219-231

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Cholesteryl ester transfer protein and its inhibition

1 reference

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Safety and tolerability of dalcetrapib (RO4607381/JTT-705): results from a 48-week trial

1 reference

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12 July 2018

Metabolism and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in humans.

1 reference

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12 July 2018

Physiologically-based PK/PD modelling of therapeutic macromolecules

1 reference

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12 July 2018

The end of the road for CETP inhibitors after torcetrapib?

1 reference

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12 July 2018

Cholesteryl ester transfer protein (CETP) inhibitors

1 reference

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Defining the role of macrophages in local moxifloxacin tissue concentrations using biopsy data and whole-body physiologically based pharmacokinetic modelling

1 reference

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Design, synthesis, and biological evaluation of (2R,alphaS)-3,4-dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-alpha-(trifluoromethyl)-1(2H)-quinolineethanol as potent and orally active cholesteryl ester transfer pro

1 reference

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12 July 2018

Cholesteryl ester transfer protein (CETP) inhibitors: is there life after torcetrapib?

1 reference

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12 July 2018

PK/PD: new insights for antibacterial and antiviral applications

1 reference

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12 July 2018

PK/PD modelling and simulations: utility in drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Effects of torcetrapib in patients at high risk for coronary events

1 reference

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12 July 2018

Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Effect of torcetrapib on the progression of coronary atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models

1 reference

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12 July 2018

From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools

1 reference

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12 July 2018

A physiological model for the estimation of the fraction dose absorbed in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Interspecies scaling and comparisons in drug development and toxicokinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3269581

12 July 2018

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

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12 July 2018

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.04064.X

21 January 2018

Is there a need for cholesteryl ester transfer protein inhibition?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.04064.X

21 January 2018

Novel tetrahydrochinoline derived CETP inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.04064.X

21 January 2018

Application of physiology-based pharmacokinetic and pharmacodynamic modeling to individualized target-controlled propofol infusions

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.04064.X

21 January 2018

Development and evaluation of a generic physiologically based pharmacokinetic model for children.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.04064.X

21 January 2018

Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.04064.X

21 January 2018

Physiology-based simulations of a pathological condition: prediction of pharmacokinetics in patients with liver cirrhosis

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https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.04064.X

21 January 2018

Whole-body physiologically based pharmacokinetic population modelling of oral drug administration: inter-individual variability of cimetidine absorption

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.04064.X

21 January 2018

Risk to the breast-fed neonate from codeine treatment to the mother: a quantitative mechanistic modeling study.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2011.04064.X

21 January 2018

Mechanism-based prediction of particle size-dependent dissolution and absorption: cilostazol pharmacokinetics in dogs.

1 reference

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21 January 2018

Analysis of nifedipine absorption from soft gelatin capsules using PBPK modeling and biorelevant dissolution testing.

1 reference

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21 January 2018

A physiologic model for simulating gastrointestinal flow and drug absorption in rats.

1 reference

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21 January 2018

Determination of the free fraction and relative free fraction of drugs strongly bound to plasma proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/21762205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of fluorescent cholesteryl ester microemulsions in cholesteryl ester transfer protein assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/21762205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Remodelling of lipoproteins in transgenic mice expressing human cholesteryl ester transfer protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/21762205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the disposition of two novel combined thromboxane synthase inhibitors/thromboxane A2 receptor antagonists in the isolated perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/21762205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development and validation of a physiology-based model for the prediction of oral absorption in monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/21762205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/21762205

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.2011.04064.X

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

release_iohtfuoksfdb5agqjnuz47h3xa

1 reference

https://api.fatcat.wiki/v0/release/iohtfuoksfdb5agqjnuz47h3xa

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

ResearchGate publication ID

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