(Q35735423)

10 August 2017

A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells (English)

1 reference

10 August 2017

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0 references

Katherine Miles

1

1 reference

10 August 2017

Jonathan Heaney

2

1 reference

10 August 2017

Zaneta Sibinska

3

1 reference

10 August 2017

Donald Salter

4

1 reference

10 August 2017

John Savill

5

1 reference

10 August 2017

David Gray

6

1 reference

10 August 2017

Mohini Gray

7

1 reference

10 August 2017

language of work or name

English

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publication date

29 December 2011

1 reference

Proceedings of the National Academy of Sciences of the United States of America

10 August 2017

1 reference

10 August 2017

109

1 reference

10 August 2017

3

1 reference

10 August 2017

887-892

1 reference

The double life of a B-1 cell: self-reactivity selects for protective effector functions

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

The importance of natural IgM: scavenger, protector and regulator

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

B cells do not take up bacterial DNA: an essential role for antigen in exposure of DNA to toll-like receptor-9.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

TLR and B cell receptor signals to B cells differentially program primary and memory Th1 responses to Salmonella enterica

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

The innate immune response to DNA.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

B-lymphocyte contributions to human autoimmune disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Autoreactivity in human IgG+ memory B cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Toll-like receptors in systemic autoimmune disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Therapeutic potential of Toll-like receptor 9 activation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

The Cellular Location of Self-antigen Determines the Positive and Negative Selection of Autoreactive B Cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

The autoantibody repertoire: searching for order

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

A blast from the past: clearance of apoptotic cells regulates immune responses.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Toll-like receptors and activation of autoreactive B cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

A Toll-like receptor recognizes bacterial DNA

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Corpse clearance defines the meaning of cell death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

CpG motifs in bacterial DNA activate leukocytes through the pH-dependent generation of reactive oxygen species.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Modulation of renal disease in autoimmune NZB/NZW mice by immunization with bacterial DNA.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

The binding of native DNA to the collagen-like segment of Clq.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Preferential autoantibody reactivity of the preimmune B cell repertoire in normal mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3271931

Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation.

12 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

Nucleosomes are exposed at the cell surface in apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

Toll-like receptor 9 signaling protects against murine lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

IL-10 produced by activated human B cells regulates CD4(+) T-cell activation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

Impaired clearance of apoptotic cells induces the activation of autoreactive anti-Sm marginal zone and B-1 B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

DNA hypomethylation is crucial for apoptotic DNA to induce systemic lupus erythematosus-like autoimmune disease in SLE-non-susceptible mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

Immunosuppressive effects of apoptotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

Toll-dependent selection of microbial antigens for presentation by dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109173109

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells

21 January 2018

1 reference

12 December 2020

Vaccination with empty plasmid DNA or CpG oligonucleotide inhibits diabetes in nonobese diabetic mice: modulation of spontaneous 60-kDa heat shock protein autoimmunity

1 reference

12 December 2020

Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis

1 reference

12 December 2020

Blebs and apoptotic bodies are B cell autoantigens

1 reference

12 December 2020

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

1 reference

12 December 2020

High proportion of Ig-producing cells making autoantibody in normal mice

1 reference

12 December 2020

The location of binding sites on C1q for DNA

1 reference

12 December 2020

Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4

1 reference

12 December 2020

Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone

1 reference

12 December 2020

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited

1 reference

12 December 2020

Positive selection of natural autoreactive B cells

1 reference

12 December 2020

Signals from a self-antigen induce positive selection in early B cell ontogeny but are tolerogenic in adults

1 reference

12 December 2020

Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus

1 reference

12 December 2020

Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1109173109

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10 August 2017

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1 reference

10 August 2017

1 reference