(Q35739624)

English

Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy

scientific article published on 19 May 2015

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy (English)

1 reference

Europe PubMed Central

10 August 2017

0 references

endoplasmic reticulum

0 references

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Xuejing Wang

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Mingming Ma

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Junfang Teng

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Xiangqian Che

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Wenwen Zhang

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Shuman Feng

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Ying Zhang

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Erxi Wu

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Xuebing Ding

10

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

language of work or name

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publication date

19 May 2015

1 reference

Europe PubMed Central

10 August 2017

International Journal of Biological Sciences

1 reference

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13 June 2020

11

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

752-761

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26078717%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Use of biomarkers in ALS drug development and clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Motoneuron firing in amyotrophic lateral sclerosis (ALS)

1 reference

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12 July 2018

Amyotrophic lateral sclerosis - cell based therapy and novel therapeutic development

1 reference

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12 July 2018

Valproate Treatment in an ALS Patient Carrying a c.194G>A Spastin Mutation and SMN2 Homozygous Deletion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Valproate pretreatment protects pancreatic β-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3β

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

New perspectives of valproic acid in clinical practice.

1 reference

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12 July 2018

Amyotrophic lateral sclerosis: Problems and prospects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Autophagy and Its Comprehensive Impact on ALS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Mismatch Discrimination and Efficient Photomodulation with Split 10-23 DNAzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Endoplasmic reticulum stress and the ER mitochondrial calcium cycle in amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Cellular model of TAR DNA-binding protein 43 (TDP-43) aggregation based on its C-terminal Gln/Asn-rich region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Autophagy dysregulation in amyotrophic lateral sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Sodium valproate induces mitochondria-dependent apoptosis in human hepatoblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Autophagy, a guardian against neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Rethinking ALS: the FUS about TDP-43.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

ALS and FTLD: two faces of TDP-43 proteinopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

TDP-43: a novel neurodegenerative proteinopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Sodium valproate exerts neuroprotective effects in vivo through CREB-binding protein-dependent mechanisms but does not improve survival in an amyotrophic lateral sclerosis mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Misfolded proteins, endoplasmic reticulum stress and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Neuroinflammation, COX-2, and ALS--a dual role?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Regulation of ER stress proteins by valproate: therapeutic implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

12 July 2018

Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

25 September 2018

Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

25 September 2018

Valproate and HDAC inhibition: a new epigenetic strategy to mitigate phenotypic severity in ALS?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

25 September 2018

Benefit of valproic acid in suppressing disease progression of ALS model mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4466456

25 September 2018

Clinical and biological changes under treatment with lithium carbonate and valproic acid in sporadic amyotrophic lateral sclerosis

1 reference

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15 November 2018

TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca²⁺ signaling in motor neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/26078717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-κB/iNOS signaling in diabetic rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/26078717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new cellular model of pathological TDP-43: The neurotoxicity of stably expressed CTF25 of TDP-43 depends on the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/26078717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26078717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.7150/IJBS.11880

1 reference

https://api.fatcat.wiki/v0/release/e4iqa2bev5cd5hrei6cuw6bgea

30 July 2022

based on heuristic

mapped directly with Wikidata item

release_e4iqa2bev5cd5hrei6cuw6bgea

1 reference

https://api.fatcat.wiki/v0/release/e4iqa2bev5cd5hrei6cuw6bgea

30 July 2022

based on heuristic

mapped directly with Wikidata item

1 reference

https://api.fatcat.wiki/v0/release/e4iqa2bev5cd5hrei6cuw6bgea

30 July 2022

based on heuristic

mapped directly with Wikidata item

1 reference

https://api.fatcat.wiki/v0/release/e4iqa2bev5cd5hrei6cuw6bgea

30 July 2022

based on heuristic

mapped directly with Wikidata item

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