(Q35743445)

10 August 2017

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title

Antimicrobial dihydrofolate reductase inhibitors--achievements and future options: review (English)

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10 August 2017

Then RL

1

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10 August 2017

publication date

1 February 2004

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10 August 2017

published in

Journal of Chemotherapy

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10 August 2017

volume

16

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10 August 2017

issue

1

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10 August 2017

page(s)

3-12

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The role of genomics in antibacterial target discovery

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

21 January 2018

Fosmidomycin for malaria

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

An alternative flavin-dependent mechanism for thymidylate synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Update on antifolate drugs targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

21 January 2018

Novel antifolate drugs

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

New insights into transmission, diagnosis, and drug treatment of Pneumocystis carinii pneumonia

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Brodimoprim, a new bacterial dihydrofolate reductase inhibitor: a minireview

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Atovaquone/proguanil: a review of its use for the prophylaxis of Plasmodium falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania

21 January 2018

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https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Molecular modeling of wild-type and antifolate resistant mutant Plasmodium falciparum DHFR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Insights into antifolate resistance from malarial DHFR-TS structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Free energy force field (FEFF) 3D-QSAR analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selec

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Synthesis of new 2,4-Diaminopyrido[2,3-d]pyrimidine and 2,4-Diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Identification of Cryptosporidium parvum dihydrofolate reductase inhibitors by complementation in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Divergent regulation of dihydrofolate reductase between malaria parasite and human host

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Multiple mutations modulate the function of dihydrofolate reductase in trimethoprim-resistant Streptococcus pneumoniae

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Enhanced in vitro activity of dihydrofolate reductase and dihydropteroase synthase inhibitors in combination against Nocardia spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Experimental in vitro efficacy study on the interaction of epiroprim plus isoniazid against Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

In vitro activities of PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite against Mycobacterium avium complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Antimicrobial activities of dihydrofolate reductase inhibitors, used singly or in combination with dapsone, against Mycobacterium ulcerans

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

In vivo activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with dapsone, against Mycobacterium leprae

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

A proposed model of Mycobacterium avium complex dihydrofolate reductase and its utility for drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Failure of trimethoprim/sulfamethoxazole prophylaxis for Pneumocystis carinii pneumonia with concurrent leucovorin use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Adjunctive folinic acid with trimethoprim-sulfamethoxazole for Pneumocystis carinii pneumonia in AIDS patients is associated with an increased risk of therapeutic failure and death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Activity of 2,4-Diaminoquinazoline Compounds against Candida species

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Use of molecular beacons to detect an antifolate resistance-associated mutation in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Plasmodium falciparum: in vitro activity of sulfadoxine and dapsone in field isolates from Kenya: point mutations in dihydropteroate synthase may not be the only determinants in sulfa resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

In vitro generation of novel pyrimethamine resistance mutations in the Toxoplasma gondii dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Activity of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone against Toxoplasma gondii

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

The pharmacology of leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Novel inhibitors of Leishmanial dihydrofolate reductase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Dicyclic and tricyclic diaminopyrimidine derivatives as potent inhibitors of Cryptosporidium parvum dihydrofolate reductase: structure-activity and structure-selectivity correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Non-classical antifolates, 5-(N-phenylpyrrolidin-3-yl)-2,4,6-triaminopyrimidines and 2,4-Diamino-6(5H)-oxopyrimidines, synthesis and antitumor studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Tobacco budworm dihydrofolate reductase is a promising target for insecticide discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

Molecular cloning and expression of the dihydrofolate reductase (DHFR) gene from adult buffalo fly (Haematobia irritans exigua): effects of antifolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1179%2FJOC.2004.16.1.3

21 January 2018

Identifiers

DOI

10.1179/JOC.2004.16.1.3

1 reference

10 August 2017

1 reference