(Q35747628)

10 August 2017

title

Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation (English)

1 reference

10 August 2017

1 reference

Marcelo L Rodriguez-Puebla

1

1 reference

10 August 2017

Paula L Miliani de Marval

2

1 reference

10 August 2017

Margaret LaCava

3

1 reference

10 August 2017

David S Moons

4

1 reference

10 August 2017

Hiroaki Kiyokawa

5

1 reference

10 August 2017

Claudio J Conti

6

1 reference

10 August 2017

language of work or name

English

0 references

publication date

1 August 2002

1 reference

The American Journal of Pathology

10 August 2017

published in

1 reference

10 August 2017

volume

161

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10 August 2017

issue

2

1 reference

10 August 2017

page(s)

405-411

1 reference

C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest

10 August 2017

cites work

1 reference

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Transgenic expression of cyclin-dependent kinase 4 results in epidermal hyperplasia, hypertrophy, and severe dermal fibrosis

27 July 2018

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Specific protection against breast cancers by cyclin D1 ablation

27 July 2018

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27 July 2018

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Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein

27 July 2018

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Preclinical and clinical development of cyclin-dependent kinase modulators

27 July 2018

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Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

27 July 2018

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

27 July 2018

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

27 July 2018

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Anomalous high p27/KIP1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/KIP1-cyclin D3 colocalization in tumor cells.

27 July 2018

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

27 July 2018

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Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes

27 July 2018

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Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors

27 July 2018

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Coupling of the cell cycle and myogenesis through the cyclin D1-dependent interaction of MyoD with cdk4

27 July 2018

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Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation

27 July 2018

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Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes

27 July 2018

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Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

27 July 2018

1 reference

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Amplification of the CDK4 gene in sarcomas: tumor specificity and relationship with the RB gene mutation

27 July 2018

1 reference

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A genetic perspective of male germ cell tumors.

27 July 2018

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Wound healing--aiming for perfect skin regeneration

27 July 2018

1 reference

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Aberrant expression of cyclin D2 is an early event in human male germ cell tumorigenesis.

27 July 2018

1 reference

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The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

27 July 2018

1 reference

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27 July 2018

1 reference

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Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

27 July 2018

1 reference

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Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas

27 July 2018

1 reference

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Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK4I, in melanoma

27 July 2018

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Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.

27 July 2018

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

27 July 2018

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27 July 2018

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Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

27 July 2018

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Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons

27 July 2018

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Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

27 July 2018

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Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma

27 July 2018

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An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Invasive melanoma in Cdk4-targeted mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Cyclin D1 represses STAT3 activation through a Cdk4-independent mechanism.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation.

25 September 2018

1 reference

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Expression of p19INK4d, CDK4, CDK6 in glioblastoma multiforme.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

ras activity and cyclin D1 expression: an essential mechanism of mouse skin tumor development

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

The 5D4 antibody (anti-cyclin D1/D2) related antigen: cytoplasmic staining is correlated to the progression of gastric cancer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Human glioblastomas with no alterations of the CDKN2A (p16INK4A, MTS1) and CDK4 genes have frequent mutations of the retinoblastoma gene

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Physical interaction of mammalian CDC37 with CDK4

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Overexpression of cyclin D2 in chronic B-cell malignancies.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Homozygous deletion of the MTS1/p16 and MTS2/p15 genes and amplification of the CDK4 gene in glioma.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1850739

Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF

25 September 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964196-X

Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group [published erratum appears in Hum Mol Genet 1998 May;7(5):941]

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964196-X

Increased expression of mutated Ha-ras during premalignant progression in SENCAR mouse skin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964196-X

Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964196-X

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964196-X

Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2964196-X

Transforming growth factor beta 1 regulation of c-myc expression, pRB phosphorylation, and cell cycle progression in keratinocytes

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12163365

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12163365

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/S0002-9440(10)64196-X

1 reference

10 August 2017

1 reference

10 August 2017

1 reference