(Q35749617)

English

Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state

scientific article published on 10 January 2012

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scholarly article

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Europe PubMed Central

PubMed publication ID

10 August 2017

Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

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Proliferation and apoptosis adaptor protein 15A

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GOA release 2020-03-11

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GOA release 2020-03-11

14

object named as

Ulrich Dirnagl

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Ingo Przesdzing

object named as

Ingo Przesdzing

8

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object named as

Dirk Megow

13

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David William Andrews

object named as

David W Andrews

15

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object named as

Andreas Meisel

16

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object named as

Josef Priller

11

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3

object named as

Anne Kamitz

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Europe PubMed Central

PubMed publication ID

10 August 2017

Philipp Mergenthaler

1

object named as

Philipp Mergenthaler

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Europe PubMed Central

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10 August 2017

author name string

Anja Kahl

2

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Europe PubMed Central

PubMed publication ID

10 August 2017

Vincent van Laak

4

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Europe PubMed Central

PubMed publication ID

10 August 2017

Katharina Stohlmann

5

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Europe PubMed Central

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10 August 2017

Susanne Thomsen

6

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Europe PubMed Central

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10 August 2017

Heiko Klawitter

7

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Europe PubMed Central

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10 August 2017

Lars Neeb

9

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Europe PubMed Central

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10 August 2017

Dorette Freyer

10

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10 August 2017

Tony J Collins

12

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10 August 2017

language of work or name

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publication date

10 January 2012

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Europe PubMed Central

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10 August 2017

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

10 August 2017

109

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Europe PubMed Central

PubMed publication ID

10 August 2017

5

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Europe PubMed Central

PubMed publication ID

10 August 2017

1518-1523

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Europe PubMed Central

PubMed publication ID

10 August 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3277118/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Subcellular localization of hexokinases I and II directs the metabolic fate of glucose

1 reference

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12 July 2018

Hypoxia-inducible factors and the response to hypoxic stress

1 reference

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12 July 2018

The engine driving the ship: metabolic steering of cell proliferation and death.

1 reference

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12 July 2018

Still embedded together binding to membranes regulates Bcl-2 protein interactions.

1 reference

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12 July 2018

Regulation of human metabolism by hypoxia-inducible factor

1 reference

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Interdependence of hypoxic and innate immune responses

1 reference

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12 July 2018

Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism.

1 reference

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12 July 2018

Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

1 reference

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12 July 2018

PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15.

1 reference

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12 July 2018

Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.

1 reference

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12 July 2018

Regulation of hexokinase binding to VDAC

1 reference

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Endogenous neuroprotection: mitochondria as gateways to cerebral preconditioning?

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Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons

1 reference

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12 July 2018

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

1 reference

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12 July 2018

ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277118

12 July 2018

Glucose phosphorylation and mitochondrial binding are required for the protective effects of hexokinases I and II.

1 reference

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12 July 2018

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

1 reference

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12 July 2018

The PEA-15/PED protein protects glioblastoma cells from glucose deprivation-induced apoptosis via the ERK/MAP kinase pathway.

1 reference

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12 July 2018

Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

1 reference

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12 July 2018

Multifaceted roles of glycolytic enzymes.

1 reference

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12 July 2018

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

1 reference

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12 July 2018

Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15

1 reference

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12 July 2018

Cell death: critical control points

1 reference

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12 July 2018

Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

1 reference

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12 July 2018

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

1 reference

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12 July 2018

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

1 reference

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12 July 2018

Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

1 reference

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Ischemic tolerance and endogenous neuroprotection

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HIF-1alpha is essential for myeloid cell-mediated inflammation

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Cell metabolism in the regulation of programmed cell death

1 reference

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12 July 2018

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

1 reference

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Growth factors can influence cell growth and survival through effects on glucose metabolism

1 reference

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12 July 2018

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

1 reference

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12 July 2018

Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis

1 reference

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PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus

1 reference

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Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

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12 July 2018

Functional organization of mammalian hexokinases: both N- and C-terminal halves of the rat type II isozyme possess catalytic sites

1 reference

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Protective conditioning of the brain: expressway or roadblock?

1 reference

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25 September 2018

A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis

1 reference

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25 September 2018

Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II.

1 reference

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25 September 2018

GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.

1 reference

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25 September 2018

Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277118

25 September 2018

Cellular expression, developmental regulation, and phylogenic conservation of PEA-15, the astrocytic major phosphoprotein and protein kinase C substrate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3277118

25 September 2018

Identifiers

10.1073/PNAS.1108225109

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

2012PNAS..109.1518M

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

ResearchGate publication ID

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