(Q35755014)

10 August 2017

title

Polymers of Z alpha1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo (English)

1 reference

10 August 2017

1 reference

5

Sabina Janciauskiene

1 reference

10 August 2017

Ravi Mahadeva

1

1 reference

10 August 2017

Carl Atkinson

2

1 reference

10 August 2017

Zhenjun Li

3

1 reference

10 August 2017

Susan Stewart

4

1 reference

10 August 2017

Diane G Kelley

6

1 reference

10 August 2017

Jasvir Parmar

7

1 reference

10 August 2017

Rebecca Pitman

8

1 reference

10 August 2017

Steven D Shapiro

9

1 reference

10 August 2017

David A Lomas

10

1 reference

10 August 2017

language of work or name

English

0 references

publication date

1 February 2005

1 reference

The American Journal of Pathology

10 August 2017

published in

1 reference

10 August 2017

volume

166

1 reference

10 August 2017

issue

2

1 reference

10 August 2017

page(s)

377-386

1 reference

The electrophoretic α1-globulin pattern of serum in α1-antitrypsin deficiency. 1963.

10 August 2017

cites work

1 reference

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The nature of small-airway obstruction in chronic obstructive pulmonary disease

2 October 2017

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Chronic obstructive pulmonary disease: molecular and cellularmechanisms

2 October 2017

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Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy

2 October 2017

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Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury

2 October 2017

1 reference

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Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8

2 October 2017

1 reference

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The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

2 October 2017

1 reference

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Structure of a serpin-protease complex shows inhibition by deformation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

The serpin superfamily of proteinase inhibitors: structure, function, and regulation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Antielastases of the human alveolar structures. Implications for the protease-antiprotease theory of emphysema

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

The Pi polymorphism: genetic, biochemical, and clinical aspects of human alpha 1-antitrypsin.

2 October 2017

1 reference

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Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Animal models of emphysema

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Z-type alpha 1-antitrypsin is less competent than M1-type alpha 1-antitrypsin as an inhibitor of neutrophil elastase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Expression of the alpha-1-antitrypsin gene in mononuclear phagocytes of normal and alpha-1-antitrypsin-deficient individuals

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Molecular basis of alpha-1-antitrypsin deficiency

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Lung polymers in Z alpha1-antitrypsin deficiency-related emphysema

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with pulmonary symptoms.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Experimental emphysema induced with purified human neutrophil elastase: tissue localization of the instilled protease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Amplification of inflammation in emphysema and its association with latent adenoviral infection

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Structural basis for serpin inhibitor activity

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Studies in alpha 1-antitrypsin deficiency.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Lung lavage fluid from patients with alpha 1-proteinase inhibitor deficiency or chronic obstructive bronchitis: anti-elastase function and cell profile

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278851

Structural insights into serpin-protease complexes reveal the inhibitory mechanism of serpins

15 November 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Liver Disease in Alpha1-Antitrypsin Deficiency Detected by Screening of 200,000 Infants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Risk of cirrhosis and primary liver cancer in alpha 1-antitrypsin deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Detection of circulating and endothelial cell polymers of Z and wild type alpha 1-antitrypsin by a monoclonal antibody

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Alpha 1-antitrypsin Pi-types in 965 COPD patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Genetic Epidemiology of COPD

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

EXPERIMENTAL EMPHYSEMA: ITS PRODUCTION WITH PAPAIN IN NORMAL AND SILICOTIC RATS

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

End-stage chronic obstructive pulmonary disease: the cigarette is burned out but inflammation rages on

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Chronic obstructive pulmonary disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Baseline characteristics of enrollees in the National Heart, Lung and Blood Institute Registry of alpha 1-antitrypsin deficiency. Alpha 1-Antitrypsin Deficiency Registry Study Group

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

A Kinetic Mechanism for the Polymerization of α1-Antitrypsin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0002-9440%2810%2962261-4

Structural evidence for methionine at the reactive site of human alpha-1-proteinase inhibitor

7 January 2021

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15681822

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Human neutrophils express the alpha 1-antitrypsin gene and produce alpha 1-antitrypsin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15681822

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15681822

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/S0002-9440(10)62261-4

1 reference

10 August 2017

1 reference

10 August 2017

1 reference