(Q35759132)

10 August 2017

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title

Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs (English)

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10 August 2017

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J. W. Mandema

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1511536

3 October 2022

M. Danhof

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1511536

3 October 2022

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1511536

3 October 2022

publication date

1 September 1992

1 reference

Clinical Pharmacokinetics

10 August 2017

published in

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10 August 2017

volume

23

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10 August 2017

issue

3

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10 August 2017

page(s)

191-215

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Letter: Pharmacokinetics of (+)-, (-)- and (plus or minus)-hexobarbitone in man after oral administration

10 August 2017

cites work

1 reference

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Pharmaco-EEG, behavioural methods and blood levels in the comparison of temazepam and flunitrazepam

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Pharmacodynamic modeling of thiopental anesthesia.

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Etomidate: a clinical and electroencephalographic comparison with thiopental

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Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited.

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Intravenous anaesthetic agents. Pharmacokinetic-pharmacodynamic relationships

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12 December 2020

Increased sensitivity to etomidate in the elderly: initial distribution versus altered brain response

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12 December 2020

Clinical and EEG effects of GB-94, a "tetracyclic" antidepressant (EEG model in discovery of a new psychotropic drug)

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12 December 2020

Pentobarbital: stereospecific actions of (+) and (-) isomers revealed on cultured mammalian neurons

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12 December 2020

Anesthetic action of opiates: correlations of lipid solubility and spectral edge

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12 December 2020

Differential effects of benzodiazepines on EEG activity and hypnogenic mechanisms of the brain stem in cats

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12 December 2020

The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat.

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12 December 2020

Relation of sedation and amnesia to plasma concentrations of midazolam in surgical patients.

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12 December 2020

Pharmacokinetic and dynamic studies with a new anxiolytic imidazo-pyridine alpidem utilizing pharmaco-EEG and psychometry

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12 December 2020

Spectral analysis of the EEG. Some fundamentals revisited and some open problems

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12 December 2020

Closed-loop feedback control of methohexital anesthesia by quantitative EEG analysis in humans

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12 December 2020

Classification of psychotropic drugs by rat EEG analysis: the anxiolytic profile in comparison to the antidepressant and neuroleptic profile

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12 December 2020

Activity of some benzodiazepine receptor ligands with reduced sedative and muscle relaxant properties on stress-induced electrocorticogram arousal in sleeping rats.

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12 December 2020

3Hsufentanil, a superior ligand for μ-opiate receptors: Binding properties and regional distribution in rat brain and spinal cord

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Novel anxiolytics that act as partial agonists at benzodiazepine receptors

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12 December 2020

Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man.

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12 December 2020

Discrimination of mode of action of anxiolytics using an integrated computer data bank and Dynamic Brain Mapping (CNS effects of diazepam and lorazepam).

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12 December 2020

The Benzodiazepine Receptor in Normal and Pathological Human Brain

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12 December 2020

An absolute must in clinico-pharmacological research: pharmaco-electroencephalography, its possibilities and limitations

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12 December 2020

Modifications of brain electrical activity after activation of the benzodiazepine receptor types in rats and rabbits

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12 December 2020

Clinical, Electroencephalographic, and Pharmacokinetic Studies of a Water-soluble Benzodiazepine, Midazolam Maleate

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12 December 2020

Anxiogenic effects of a benzodiazepine receptor partial inverse agonist, RO 19-4603, in a light/dark choice situation

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12 December 2020

Pharmacokinetic-pharmacodynamic modelling of the interaction between flumazenil and midazolam in volunteers by aperiodic EEG analysis.

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12 December 2020

EEG quantitation of narcotic effect: the comparative pharmacodynamics of fentanyl and alfentanil

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12 December 2020

Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship

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12 December 2020

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis.

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12 December 2020

Relationships between quantitative EEG measures and pharmacodynamics of alfentanil in dogs

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12 December 2020

Pharmacodynamic characterization of the electroencephalographic effects of thiopental in rats

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12 December 2020

Pharmacokinetics of the enantiomers of hexobarbital studied in the same intact rat and in the same isolated perfused rat liver

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12 December 2020

Blood levels and electroencephalographic effects of diazepam and bromazepam

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12 December 2020

Reevaluation of potency and pharmacokinetic properties of some lipid-soluble barbiturates with an EEG-threshold method.

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12 December 2020

Pharmacology of the benzodiazepine receptor

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12 December 2020

Closed-loop feedback control of propofol anaesthesia by quantitative EEG analysis in humans.

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12 December 2020

Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo.

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12 December 2020

Effects of benzodiazepines and non-benzodiazepine compounds on the GABA-induced response in frog isolated sensory neurones

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12 December 2020

Pharmacological and behavioral profile of alpidem as an anxiolytic

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12 December 2020

Disposition of hexobarbital enantiomers in the rat

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12 December 2020

Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam.

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12 December 2020

Intrinsic and antagonistic effects of beta-carboline FG 7142 on behavioral and EEG actions of benzodiazepines and pentobarbital in cats.

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12 December 2020

Computer EEG drug data base in psychopharmacology and in drug development

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12 December 2020

A review of the continuum of drug-induced states of excitation and depression.

1 reference

12 December 2020

Tolerance to alprazolam after intravenous bolus and continuous infusion: psychomotor and EEG effects.

1 reference

12 December 2020

Pharmacological studies with quazepam, a new benzodiazepine hypnotic

1 reference

12 December 2020

Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation

1 reference

12 December 2020

An electroencephalographic processing algorithm specifically intended for analysis of cerebral electrical activity

1 reference

12 December 2020

Functional in vivo correlates of the benzodiazepine agonist-inverse agonist continuum

1 reference

12 December 2020

In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy

1 reference

12 December 2020

Ro 16-6028: a novel anxiolytic acting as a partial agonist at the benzodiazepine receptor

1 reference

12 December 2020

Animal models of the epilepsies

1 reference

12 December 2020

Antiepileptic drugs and the electroencephalogram

1 reference

12 December 2020

Estimation of sensitivity to hexobarbitone (enhexymal NFN) in rats by an EEG threshold.

1 reference

12 December 2020

A pharmacodynamic evaluation of midazolam as an antiepileptic compound

1 reference

12 December 2020

Pharmacodynamic interaction between midazolam and a specific benzodiazepine antagonist in humans.

1 reference

12 December 2020

Comparative pharmacology of the ketamine isomers. Studies in volunteers

1 reference

12 December 2020

Intraoperative EEG patterns: implications for EEG monitoring.

1 reference

12 December 2020

Separate site(s) of action of optical isomers of 1-methyl-5-phenyl-5-propylbarbituric acid with opposite pharmacological activities at the GABA receptor complex.

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration

1 reference

12 December 2020

Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788.

1 reference

12 December 2020

Relationship between plasma concentration and effect of midazolam after oral and intravenous administration

1 reference

12 December 2020

Quantification of the EEG effect of midazolam by aperiodic analysis in volunteers. Pharmacokinetic/pharmacodynamic modelling.

1 reference

12 December 2020

A model for studying depth of anesthesia and acute tolerance to thiopental.

1 reference

12 December 2020

Pharmacoelectroencephalographic study of brotizolam, a novel hypnotic

1 reference

12 December 2020

Pharmaco-EEG and Psychometric Study of the Effect of Single Doses of Temazepam and Nitrazepam

1 reference

12 December 2020

Chronic alcohol intake does not change thiopental anesthetic requirement, pharmacokinetics, or pharmacodynamics

1 reference

12 December 2020

Electroencephalographic effects of benzodiazepines. I. Choosing an electroencephalographic parameter to measure the effect of midazolam on the central nervous system.

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overview

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system.

1 reference

12 December 2020

Autoradiographic demonstration of the selectivity of two 1-N-trifluoroethyl benzodiazepines for the BZD-1 receptors in the rat brain.

1 reference

12 December 2020

Selectivity for omega-receptor subtypes as a strategy for the development of anxiolytic drugs

1 reference

12 December 2020

Plasma levels of thiopental necessary for anesthesia

1 reference

12 December 2020

COMSTAT rule for vigilance classification based on spontaneous EEG activity

1 reference

12 December 2020

Quantitation of the EEG and pharmacodynamic modelling of hypnotic drugs: etomidate as an example.

1 reference

12 December 2020

Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects

1 reference

12 December 2020

Hexobarbitone sleeping time in rats following doses with similar EEG changes

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic modelling of propofol ('Diprivan') in volunteers and surgical patients

1 reference

12 December 2020

Threshold hypnotic concentration of methohexitone.

1 reference

12 December 2020

Pharmacological profile of the imidazopyridine zolpidem at benzodiazepine receptors and electrocorticogram in rats.

1 reference

12 December 2020

Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

1 reference

12 December 2020

Stereospecificity of anesthetic activity, distribution, inactivation and protein binding of the optical antipodes of two N-methylated barbiturates

1 reference

12 December 2020

Electroencephalographic effects of benzodiazepines. II. Pharmacodynamic modeling of the electroencephalographic effects of midazolam and diazepam.

1 reference

12 December 2020

Kinetics of pharmacologic response

1 reference

12 December 2020

The EEG as a monitor of midazolam amnesia: changes in power and topography as a function of amnesic state

1 reference

12 December 2020

In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: midazolam and flumazenil

1 reference

12 December 2020

1 reference

12 December 2020

Effects of a benzodiazepine antagonist on the diazepam-induced electrical brain activity modifications.

1 reference

12 December 2020

Estimation of amobarbital plasma-effect site equilibration kinetics. Relevance of polyexponential conductance functions

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers.

1 reference

12 December 2020

The effect of increasing age on thiopental disposition and anesthetic requirement.

1 reference

12 December 2020

Several new benzodiazepines selectively interact with a benzodiazepine receptor subtype

1 reference

12 December 2020

Electroencephalographic quantitation of opioid effect: comparative pharmacodynamics of fentanyl and sufentanil

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity.

1 reference

12 December 2020

Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.

1 reference

12 December 2020

Plasma protein binding and distribution of fentanyl, sufentanil, alfentanil and lofentanil in blood

1 reference

12 December 2020

Topographic EEG changes with benzodiazepine administration in generalized anxiety disorder

1 reference

12 December 2020

Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions

1 reference

12 December 2020

Hypnotics: clinical value of pharmaco-EEG methods.

1 reference

12 December 2020

Quantitative EEG analysis during anaesthesia with isoflurane in nitrous oxide at 1.3 and 1.5 MAC.

1 reference

12 December 2020

Drug effects on the EEG of various species of laboratory animals

1 reference

12 December 2020

Quantitative pharmaco-EEG and performance after administration of brotizolam to healthy volunteers

1 reference

12 December 2020

Relationship Between EEG Dynamics and Pharmacokinetics of the Benzodiazepine Lormetazepam

1 reference

12 December 2020

Inhibition of photosensitive seizures in man by the beta-carboline, ZK 95962, a selective benzodiazepine receptor agonist

1 reference

12 December 2020

10.2165/00003088-199223030-00003

Identifiers

DOI

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Dimensions Publication ID

10 August 2017

1003481007

0 references

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