(Q35776779)

10 August 2017

title

Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site (English)

1 reference

10 August 2017

1 reference

R M Hartley

1

1 reference

10 August 2017

J Peng

2

1 reference

10 August 2017

G A Fest

3

1 reference

10 August 2017

S Dakshanamurthy

4

1 reference

10 August 2017

D E Frantz

5

1 reference

10 August 2017

M L Brown

6

1 reference

10 August 2017

S L Mooberry

7

1 reference

10 August 2017

language of work or name

1 reference

14 December 2011

1 reference

10 August 2017

published in

Molecular Pharmacology

1 reference

10 August 2017

volume

81

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10 August 2017

issue

3

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10 August 2017

page(s)

431-439

1 reference

Synthesis and biological activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents

10 August 2017

cites work

1 reference

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Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel

12 July 2018

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Comparison of neuropathy-inducing effects of eribulin mesylate, paclitaxel, and ixabepilone in mice

12 July 2018

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ELR510444, a novel microtubule disruptor with multiple mechanisms of action

12 July 2018

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Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Microtubule-binding agents: a dynamic field of cancer therapeutics

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Microtubules and resistance to tubulin-binding agents

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4.

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

The role of betaIII tubulin in predicting chemoresistance in non-small cell lung cancer.

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.

12 July 2018

1 reference

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A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Ixabepilone: targeting betaIII-tubulin expression in taxane-resistant malignancies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms

12 July 2018

1 reference

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Class III beta-tubulin isotype predicts response in advanced breast cancer patients randomly treated either with single-agent doxorubicin or docetaxel

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Paclitaxel induces primary and postmitotic G1 arrest in human arterial smooth muscle cells.

12 July 2018

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Development and testing of a general amber force field

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Multidrug resistance in cancer: role of ATP-dependent transporters

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Multiple forms of tubulin: different gene products and covalent modifications

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Microtubule dynamics in vitro are regulated by the tubulin isotype composition

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Cryptophycin: a new antimicrotubule agent active against drug-resistant cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Promotion of fluorescence upon binding of colchicine to tubulin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Antineoplastic agents, 122. Constituents of Combretum caffrum

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

New colorimetric cytotoxicity assay for anticancer-drug screening

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Kinetics of colchicine binding to purified beta-tubulin isotypes from bovine brain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Podophyllotoxin as a probe for the colchicine binding site of tubulin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Comparative modelling of human β tubulin isotypes and implications for drug binding.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Binding of indanocine to the colchicine site on tubulin promotes fluorescence, and its binding parameters resemble those of the colchicine analogue AC.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

DFT-GIAO study of aryltetralin lignan lactones: conformational analyses and chemical shifts calculations.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Expression of multidrug resistance-1 protein inversely correlates with paclitaxel response and survival in ovarian cancer patients: a study in serial samples

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Novel 2-methoxyestradiol analogues with antitumor activity

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Predicting chemotherapy response to paclitaxel-based therapy in advanced non-small-cell lung cancer with P-glycoprotein expression.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3286304

Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22169850

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22169850

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of chance observations in chemotherapy: Vinca rosea

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22169850

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/MOL.111.075838

1 reference

10 August 2017

1 reference

10 August 2017

1 reference