(Q35781141)

English

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis

scientific article published on May 14, 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis (English)

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

Streptomyces argillaceus

1 reference

Streptomyces venezuelae

1 reference

1 reference

(3S,6R)-19-[(2S,4R,5R,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-11-hydroxy-3-(hydroxymethyl)-9-methyl-5-oxa-2-azapentacyclo[11.8.0.02,6.07,12.015,20]henicosa-1(13),7(12),8,10,15(20),16,18-heptaene-4,14,21-trione

1 reference

1 reference

(1S)-1beta-[(R)-1-Hydroxyethyl]-5-methyl-7-hydroxy-12-[[(2S)-4beta,5beta-dihydroxy-6alpha-methyltetrahydro-2H-pyran-2beta-yl]oxy]-1,2,3aalpha,13-tetrahydro-8H-benzo[b]oxazolo[3,2-f]phenanthridine-2,8,13-trione

1 reference

1 reference

(3S,6R)-19-[(2S,4R,5R,6S)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-11-hydroxy-3-[(1R)-1-hydroxyethyl]-9-methyl-5-oxa-2-azapentacyclo[11.8.0.02,6.07,12.015,20]henicosa-1(13),7(12),8,10,15(20),16,18-heptaene-4,14,21-trione

1 reference

Demycarosyl-mithramycin

1 reference

1 reference

Demycarosyl mithramycin SK

1 reference

1 reference

(1S)-1beta-Isopropyl-5-methyl-7-hydroxy-12-[[(2S)-4beta,5beta-dihydroxy-6alpha-methyltetrahydro-2H-pyran-2beta-yl]oxy]-1,2,3aalpha,13-tetrahydro-8H-benzo[b]oxazolo[3,2-f]phenanthridine-2,8,13-trione

1 reference

CFCUWKMKBJTWLW-XGHULXNCSA-N

1 reference

interface and colloid science

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

Alfredo F. Braña

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Alfredo F Braña

5

0 references

object named as

Carmen Méndez

8

0 references

author name string

Mohammad Nur-e-Alam

3

1 reference

Europe PubMed Central

PubMed publication ID

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Uwe Rix

6

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Jürgen Rohr

10

1 reference

Europe PubMed Central

PubMed publication ID

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Lily L. Remsing

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1 reference

Europe PubMed Central

PubMed publication ID

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31 December 2023

Ana M. González

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1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733914

31 December 2023

Marcos A. Oliveira

7

1 reference

Europe PubMed Central

PubMed publication ID

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31 December 2023

José A. Salas

9

1 reference

Europe PubMed Central

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31 December 2023

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17 April 2003

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16 September 2022

full work available at URL

https://europepmc.org/articles/pmc4480629?pdf=render

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733914

31 December 2023

19 March 2024

https://api.unpaywall.org/v2/10.1021/ja034162h?email=unpaywall_01@example.com

https://europepmc.org/articles/PMC4480629

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733914

31 December 2023

https://europepmc.org/articles/PMC4480629?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733914

31 December 2023

https://doi.org/10.1021/ja034162h

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733914

31 December 2023

https://pubs.acs.org/doi/pdf/10.1021/ja034162h

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

Journal of the American Chemical Society

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

125

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

5745-5753

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

online access status

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1021/ja034162h?email=unpaywall_01@example.com

access restriction status

1 reference

based on heuristic

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MITHRAMYCIN IN THE TREATMENT OF DISSEMINATED TESTICULAR NEOPLASMS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Modification of post-PKS tailoring steps through combinatorial biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Mining the National Cancer Institute's tumor-screening database: identification of compounds with similar cellular activities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Genome Sequence of the Radioresistant Bacterium Deinococcus radiodurans R1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

The Structure of Mithramycin Reinvestigated

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Identification of two genes from Streptomyces argillaceus encoding glycosyltransferases involved in transfer of a disaccharide during biosynthesis of the antitumor drug mithramycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

The sugars in chromomycin A3 stabilize the Mg(2+)-dimer complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Solution structure of the mithramycin dimer-DNA complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Selective toxicity to malaria parasites by non-intercalating DNA-binding ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Solution structure of mithramycin dimers bound to partially overlapping sites on DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

A comprehensive set of sequence analysis programs for the VAX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Effect of mithramycin on normal and abnormal bone turnover.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Investigations into the sequence-selective binding of mithramycin and related ligands to DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Basic local alignment search tool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Protein database searches for multiple alignments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Proliferation of human ocular fibroblasts. An assessment of in vitro colorimetric assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Structure refinement of the chromomycin dimer-DNA oligomer complex in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

DNA sequencing with chain-terminating inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

12 July 2018

Durhamycin A, a potent inhibitor of HIV Tat transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

25 September 2018

The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

25 September 2018

Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

25 September 2018

The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

25 September 2018

Derivatives of pUC18 that have BglII sites flanking a modified multiple cloning site and that retain the ability to identify recombinant clones by visual screening of Escherichia coli colonies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4480629

25 September 2018

Interaction of the DNA-binding antitumor antibiotics, chromomycin and mithramycin with erythroid spectrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12733914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutational analysis of the enterocin favorskii biosynthetic rearrangement

1 reference

https://pubmed.ncbi.nlm.nih.gov/12733914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Two Polyketide Methyltransferases Involved in the Biosynthesis of the Antitumor Drug Mithramycin byStreptomyces argillaceus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12733914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mithramycin in the treatment of Paget's disease of bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/12733914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UCH9, a new antitumor antibiotic produced by Streptomyces. II. Structure elucidation of UCH9 by mass and NMR spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12733914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biogenesis of chromomycin A3 by Streptomyces griseus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12733914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12733914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experiences in the Treatment of Paget's Disease of Bone With Mithramycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12733914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species Diversity and Invasion Resistance in a Marine Ecosystem

1 reference

27 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1126/SCIENCE.286.5444.1577

The Biosynthesis of Aureolic Acid Group Antibiotics

3

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

Nucleic Acids Research

7

13

8714

author name string

Fox K. R.

publication date

1985

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

Journal of Molecular Biology

18

223

279

author name string

Gao X. L.

publication date

1992

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

Journal of Bacteriology

22

180

4937

author name string

Fernandez E.

publication date

1998

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

Journal of Biological Chemistry

26

275

3074

author name string

Fernandez-Lonzano M. J.

publication date

2000

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

Journal of Bacteriology

44

180

4937

author name string

Fernandez E.

publication date

1998

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

45

124

134

author name string

Janssen G.

publication date

1993

1 reference

10.1021/JA034162H

https://api.crossref.org/works/10.1021/JA034162H

31 December 2023

Identification of Two Genes from Streptomyces argillaceus Encoding Glycosyltransferases Involved in Transfer of a Disaccharide during Biosynthesis of the Antitumor Drug Mithramycin

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1128/JB.180.18.4929-4937.1998

Identifiers

10.1021/JA034162H

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

ResearchGate publication ID

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