(Q35783124)

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Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells

scientific article published on May 2015

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scholarly article

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Europe PubMed Central

10 August 2017

Chronic Exposure to Excess Nutrients Left-shifts the Concentration Dependence of Glucose-stimulated Insulin Secretion in Pancreatic β-Cells (English)

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Europe PubMed Central

10 August 2017

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10 June 2020

author name string

Karel A Erion

1

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10 June 2020

Charles A Berdan

2

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10 June 2020

Nathan E Burritt

3

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10 June 2020

Barbara E Corkey

4

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10 June 2020

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1 May 2015

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10 August 2017

Journal of Biological Chemistry

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10 June 2020

290

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10 June 2020

26

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10 June 2020

16191-16201

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10 June 2020

describes a project that uses

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11 June 2022

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Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells

1 reference

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12 July 2018

Metabolic signaling in fuel-induced insulin secretion

1 reference

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12 July 2018

Diabetes: have we got it all wrong? Insulin hypersecretion and food additives: cause of obesity and diabetes?

1 reference

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12 July 2018

The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions

1 reference

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12 July 2018

Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol

1 reference

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12 July 2018

Banting lecture 2011: hyperinsulinemia: cause or consequence?

1 reference

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12 July 2018

The dual control of insulin secretion by glucose involves triggering and amplifying pathways in β-cells

1 reference

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12 July 2018

Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine

1 reference

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12 July 2018

Insulin and insulin signaling play a critical role in fat induction of insulin resistance in mouse

1 reference

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12 July 2018

Regulation of SNAP-25 trafficking and function by palmitoylation

1 reference

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12 July 2018

Glucolipotoxicity of the pancreatic beta cell.

1 reference

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12 July 2018

Insulin resistance and hyperinsulinemia: is hyperinsulinemia the cart or the horse?

1 reference

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12 July 2018

Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.

1 reference

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12 July 2018

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481219

12 July 2018

Fatty acid signaling in the beta-cell and insulin secretion

1 reference

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12 July 2018

Islet beta cell failure in type 2 diabetes

1 reference

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12 July 2018

Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic beta-cells

1 reference

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12 July 2018

Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet

1 reference

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12 July 2018

Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells

1 reference

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12 July 2018

Palmitoylation sites and processing of synaptotagmin I, the putative calcium sensor for neurosecretion

1 reference

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12 July 2018

Glucose-regulated gene expression maintaining the glucose-responsive state of beta-cells

1 reference

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12 July 2018

Beta-cell adaptation and decompensation during the progression of diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481219

12 July 2018

Triggering and amplifying pathways of regulation of insulin secretion by glucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481219

12 July 2018

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481219

12 July 2018

Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).

1 reference

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12 July 2018

Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism

1 reference

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12 July 2018

Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481219

12 July 2018

A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties

1 reference

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12 July 2018

Pancreatic beta-cell glucokinase: closing the gap between theoretical concepts and experimental realities.

1 reference

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12 July 2018

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

1 reference

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12 July 2018

Mechanisms of insulin resistance in experimental hyperinsulinemic dogs

1 reference

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12 July 2018

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation

1 reference

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12 July 2018

Induction by glucose of genes coding for glycolytic enzymes in a pancreatic beta-cell line (INS-1).

1 reference

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12 July 2018

Glucose-induced oscillatory insulin secretion in perifused rat pancreatic islets and clonal beta-cells (HIT).

1 reference

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12 July 2018

Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

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Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

1 reference

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Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates

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Changes in hepatocyte NADH fluorescence during prolonged hypoxia.

1 reference

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12 July 2018

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

1 reference

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12 July 2018

Insulin secretion and clearance during low-dose graded glucose infusion.

1 reference

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12 July 2018

Nile red: a selective fluorescent stain for intracellular lipid droplets

1 reference

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12 July 2018

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects

1 reference

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12 July 2018

Coupling of beta-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats

1 reference

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12 July 2018

Cholesterol and regulated exocytosis: a requirement for unitary exocytotic events.

1 reference

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In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse: pattern and role of cytoplasmic Ca2+ and amplification signals in beta-cells

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Quantitative NAD(P)H/flavoprotein autofluorescence imaging reveals metabolic mechanisms of pancreatic islet pyruvate response

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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

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25 September 2018

Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4481219

25 September 2018

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

1 reference

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25 September 2018

Hyperinsulinemia of obesity is due to decreased clearance of insulin

1 reference

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α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/25934392

12 December 2020

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inferred from PubMed ID database lookup

Glucokinase in pancreatic B-cells and its inhibition by alloxan

1 reference

https://pubmed.ncbi.nlm.nih.gov/25934392

12 December 2020

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inferred from PubMed ID database lookup

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25934392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of chronically elevated glucose levels on the functional properties of rat pancreatic beta-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25934392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/25934392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free fatty acid-induced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/25934392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M114.620351

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25934392%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25934392%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25934392%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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