(Q42475368)

1 November 2017

title

Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism (English)

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1 November 2017

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1 reference

Zhou YP

1

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1 November 2017

Cockburn BN

series ordinal

2

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1 November 2017

Pugh W

series ordinal

3

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1 November 2017

Polonsky KS

series ordinal

4

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1 November 2017

publication date

1 July 1999

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1 November 2017

number of pages

8

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based on heuristic

inferred from page(s)

published in

Metabolism

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1 November 2017

volume

48

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1 November 2017

issue

7

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1 November 2017

page(s)

857-864

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Unresponsiveness to glucose in a streptozocin model of diabetes. Inappropriate insulin and glucagon responses to a reduction of glucose concentration

1 November 2017

cites work

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Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat

7 January 2021

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Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

7 January 2021

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Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

7 January 2021

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Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes

7 January 2021

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Abnormal Glucose Regulation of Insulin Secretion in Models of Reduced B-Cell Mass

7 January 2021

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Possible role of glycogen accumulation in B-cell glucotoxicity

7 January 2021

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Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes

7 January 2021

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Proinsulin processing in the regulated and the constitutive secretory pathway

7 January 2021

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Stages of regulated exocytosis

7 January 2021

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Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

7 January 2021

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Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans

7 January 2021

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A simple, rapid, and sensitive DNA assay procedure

7 January 2021

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Effects of Iodoacetate, Mannoheptulose and 3-O-Methyl Glucose on the Secretory Function and Metabolism of Isolated Pancreatic Islets

7 January 2021

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Activation of stimulus-secretion coupling in pancreatic beta-cells by specific products of glucose metabolism. Evidence for privileged signaling by glycolysis.

7 January 2021

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Antidiabetic agents: a new class of reversible carnitine palmitoyltransferase I inhibitors

7 January 2021

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Metabolic coupling factors in pancreatic beta-cell signal transduction

7 January 2021

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Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells

7 January 2021

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Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization

7 January 2021

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(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

7 January 2021

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A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide

7 January 2021

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Dissociation between exocytosis and Ca(2+)-channel activity in mouse pancreatic beta-cells stimulated with calmidazolium (compound R24571).

7 January 2021

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The molecular genetics of rodent single gene obesities

7 January 2021

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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

7 January 2021

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Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?

7 January 2021

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Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids

7 January 2021

1 reference

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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

7 January 2021

1 reference

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A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties

7 January 2021

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Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility

7 January 2021

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10.1016/S0026-0495(99)90219-6

7 January 2021

Identifiers

DOI

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1 November 2017

1 reference