(Q41665996)

6 October 2017

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title

The molecular genetics of rodent single gene obesities (English)

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6 October 2017

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1

Leibel RL

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6 October 2017

Chung WK

2

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PubMed ID

9405382

6 October 2017

Chua SC Jr

series ordinal

3

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PubMed ID

9405382

6 October 2017

language of work or name

English

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publication date

1 December 1997

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Journal of Biological Chemistry

6 October 2017

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6 October 2017

272

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6 October 2017

31937-31940

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6 October 2017

51

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Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors

6 October 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Molecular characterization of the mouse agouti locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Mechanisms for the pleiotropic effects of the agouti gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

The agouti gene: turned on to yellow

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Structure and function of ASP, the human homolog of the mouse agouti gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

A candidate gene for the mouse mutation tubby

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Identification of four chromosomal loci determining obesity in a multifactorial mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Brown adipose tissue metabolism and thermogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Enlargement of epididymal adipocytes in relation to hyperinsulinemia in obese hyperglycemic mice (ob-ob).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Acute, chronic, and interactive effects of type I and II corticosteroid receptor stimulation on feeding and weight gain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Molecular mapping of the mouse ob mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Positional cloning of the mouse obese gene and its human homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

The role of neuropeptide Y in the antiobesity action of the obese gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Effects of the obese gene product on body weight regulation in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Weight-reducing effects of the plasma protein encoded by the obese gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Role of leptin in the neuroendocrine response to fasting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Leptin accelerates the onset of puberty in normal female mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Extreme obesity may be linked to markers flanking the human OB gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Indication for linkage of the human OB gene region with extreme obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Mutation screening and identification of a sequence variation in the human ob gene coding region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Absence of mutations in the human OB gene in obese/diabetic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Increased obese mRNA expression in omental fat cells from massively obese humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Transient increase in obese gene expression after food intake or insulin administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Modulation of insulin activities by leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Identification of targets of leptin action in rat hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Leptin receptor missense mutation in the fatty Zucker rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Abnormal splicing of the leptin receptor in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Defective STAT signaling by the leptin receptor in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

The molecular basis of the obese mutation in ob2J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

A short form of leptin receptor performs signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Molecular cloning of rat leptin receptor isoform complementary DNAs--identification of a missense mutation in Zucker fatty (fa/fa) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

OB protein binds specifically to the choroid plexus of mice and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Evidence for linkage between a region on chromosome 1p and the acute insulin response in Pima Indians.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Suggestive linkages between markers on human 1p32-p22 and body fat and insulin levels in the Quebec Family Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Genomic structure of the human OB receptor and identification of two novel intronic microsatellites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

And finally, genes for human obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

Effects of gender, body composition, and menopause on plasma concentrations of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.272.51.31937

21 January 2018

Identifiers

DOI

10.1074/JBC.272.51.31937

1 reference

6 October 2017

1 reference

PubMed ID

9405382