(Q35786977)

10 August 2017

title

Aggregation of α-synuclein is kinetically controlled by intramolecular diffusion (English)

1 reference

10 August 2017

1 reference

Basir Ahmad

1

1 reference

10 August 2017

Yujie Chen

series ordinal

2

1 reference

10 August 2017

Lisa J Lapidus

series ordinal

3

1 reference

10 August 2017

language of work or name

English

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publication date

27 January 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

10 August 2017

published in

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10 August 2017

volume

109

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10 August 2017

issue

7

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10 August 2017

page(s)

2336-2341

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A soluble α-synuclein construct forms a dynamic tetramer

10 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Single molecule characterization of α-synuclein in aggregation-prone states

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Extremely slow intramolecular diffusion in unfolded protein L

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Early aggregation steps in alpha-synuclein as measured by FCS and FRET: evidence for a contagious conformational change.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Unfolded-state dynamics and structure of protein L characterized by simulation and experiment

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

The rate of intramolecular loop formation in DNA and polypeptides: the absence of the diffusion-controlled limit and fractional power-law viscosity dependence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Structural characterization of alpha-synuclein in an aggregation prone state.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Synchronous vs asynchronous chain motion in alpha-synuclein contact dynamics

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Alpha-synuclein tertiary contact dynamics

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Sensitivity of secondary structure propensities to sequence differences between alpha- and gamma-synuclein: implications for fibrillation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Effects of denaturants on the dynamics of loop formation in polypeptides

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Protein aggregation and amyloidosis: confusion of the kinds?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

How fast is protein hydrophobic collapse?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Alpha-synuclein and neurodegenerative diseases

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Measuring the rate of intramolecular contact formation in polypeptides

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Alpha-synuclein in Lewy bodies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Conformational properties of alpha-synuclein in its free and lipid-associated states

12 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

Tertiary contact formation in alpha-synuclein probed by electron transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

Measurement of submicrosecond intramolecular contact formation in peptides at the single-molecule level

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

Segmental conformational disorder and dynamics in the intrinsically disordered protein α-synuclein and its chain length dependence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

A general polymer model of unfolded proteins under folding conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

Conformational properties of unfolded HypF-N.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

The intrinsic stiffness of polyglutamine peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

Dynamics of intramolecular contact formation in polypeptides: distance dependence of quenching rates in a room-temperature glass.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

Time-resolved FRET detection of subtle temperature-induced conformational biases in ensembles of α-synuclein molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

Characterization of intrinsically disordered proteins with electrospray ionization mass spectrometry: conformational heterogeneity of alpha-synuclein

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3289313

Effects of Chain Stiffness on the Dynamics of Loop Formation in Polypeptides. Appendix: Testing a 1-Dimensional Diffusion Model for Peptide Dynamics

25 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1109526109

21 January 2018

Identifiers

DOI

10.1073/PNAS.1109526109

1 reference

10 August 2017

0 references

1 reference

10 August 2017

1 reference