(Q35788038)

10 August 2017

title

Extending clinical equipoise to phase 1 trials involving patients: unresolved problems (English)

1 reference

10 August 2017

main subject

phase I clinical trial

0 references

2

Jonathan Kimmelman

1 reference

10 August 2017

James A Anderson

1

1 reference

10 August 2017

publication date

1 March 2010

1 reference

Kennedy Institute of Ethics Journal

10 August 2017

published in

1 reference

10 August 2017

volume

20

1 reference

10 August 2017

issue

1

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10 August 2017

page(s)

75-98

1 reference

Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail?

10 August 2017

cites work

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12 July 2018

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Dose escalation methods in phase I cancer clinical trials

12 July 2018

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Benefit in phase 1 oncology trials: therapeutic misconception or reasonable treatment option?

12 July 2018

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Ethical, scientific, and regulatory perspectives regarding the use of placebos in cancer clinical trials

12 July 2018

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Ethics at phase 0: clarifying the issues

12 July 2018

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Assessing research risks systematically: the net risks test

12 July 2018

1 reference

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Risks and benefits associated with novel phase 1 oncology trial designs

12 July 2018

1 reference

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The irrelevance of equipoise

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Lost in translation: treatment trials in the SOD1 mouse and in human ALS.

12 July 2018

1 reference

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Comparison of treatment effects between animal experiments and clinical trials: systematic review

12 July 2018

1 reference

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Trust based obligations of the state and physician-researchers to patient-subjects.

12 July 2018

1 reference

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"Therapeutic intent" in phase 1 oncology trials: a justifiable objective

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Phase I research and the meaning of direct benefit

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Reasonable risks in clinical research: a critique and a proposal for the Integrative Approach

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke

12 July 2018

1 reference

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Phase I trial design for solid tumor studies of targeted, non-cytotoxic agents: theory and practice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

The Cancer Research UK experience of pre-clinical toxicology studies to support early clinical trials with novel cancer therapies

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Pooling of animal experimental data reveals influence of study design and publication bias

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

12 July 2018

Rehabilitating Equipoise

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Medicine. The NIH Roadmap

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Ethics of phase 1 oncology studies: reexamining the arguments and data

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

A critique of clinical equipoise. Therapeutic misconception in the ethics of clinical trials

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Emergency medicine animal research: does use of randomization and blinding affect the results?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Defining and describing benefit appropriately in clinical trials

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

For and against: clinical equipoise and not the uncertainty principle is the moral underpinning of the randomised controlled trial

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Evaluation of rodent-only toxicology for early clinical trials with novel cancer therapeutics

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Placebo-controlled trials in schizophrenia: are they ethical? Are they necessary?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Study of cohort-specific consent and patient control in phase I cancer trials.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Surrogate end points in clinical trials: are we being misled?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Questing for grails: duplicity, betrayal and self-deception in postmodern medical research.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Leaving therapy to chance.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Equipoise and the ethics of clinical research

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Demarcating research and treatment: a systematic approach for the analysis of the ethics of clinical research

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Pulling the plug on clinical equipoise: a critique of Miller and Weijer.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

A renewed call for equipoise.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Equipoise and the duty of care in clinical research: a philosophical response to our critics.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Articulating and responding to uncertainties in clinical research.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Equipoise and the criteria for reasonable action.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Does Research Ethics Rest on a Mistake? The Common Good, Reasonable Risk and Social Justice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Risks and benefits of phase 1 oncology trials, 1991 through 2002.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

When are research risks reasonable in relation to anticipated benefits?

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

The importance of preservation of the ethical principle of equipoise in the design of clinical trials: relative impact of the methodological quality domains on the treatment effect in randomized controlled trials.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Phase I clinical trial design in cancer drug development

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Rethinking Risk-Benefit Assessment for Phase I Cancer Trials

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

The ethics and science of placebo-controlled trials: assay sensitivity and the Duhem-Quine thesis

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

The ethics of placebo-controlled trials

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Equipoise, knowledge and ethics in clinical research and practice

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4482670

Using the continual reassessment method: lessons learned from an EORTC phase I dose finding study

15 November 2018

1 reference

12 December 2020

Placebo-controlled trials and the logic of clinical purpose

1 reference

12 December 2020

Autologous stem cell transplantation for progressive multiple sclerosis: Update of the European Group for Blood and Marrow Transplantation autoimmune diseases working party database

1 reference

12 December 2020

Critical role of phase I clinical trials in cancer treatment. American Society of Clinical Oncology

1 reference

12 December 2020

Predictive value of preclinical toxicology studies for platinum anticancer drugs

1 reference

12 December 2020

Accelerated titration designs for phase I clinical trials in oncology

1 reference

12 December 2020

Users' Guides to the Medical Literature: XXV. Evidence-based medicine: principles for applying the Users' Guides to patient care. Evidence-Based Medicine Working Group

1 reference

12 December 2020

Patient specific dosing in a cancer phase I clinical trial

1 reference

12 December 2020

Identifiers

PMC publication ID

4482670

1 reference

10 August 2017

1 reference