(Q35791628)

10 August 2017

title

Neuroinflammation in the aging down syndrome brain; lessons from Alzheimer's disease (English)

1 reference

10 August 2017

0 references

0 references

1 reference

Donna M Wilcock

1

1 reference

10 August 2017

language of work or name

1 reference

21 February 2012

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Current gerontology and geriatrics research

10 August 2017

published in

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10 August 2017

volume

2012

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10 August 2017

page(s)

170276

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Creative Commons Attribution 3.0 Unported

10 August 2017

copyright license

start time

1 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

12 July 2018

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National estimates and race/ethnic-specific variation of selected birth defects in the United States, 1999-2001.

12 July 2018

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Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

12 July 2018

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Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis

12 July 2018

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Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis

12 July 2018

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Regulation of NADPH oxidases: the role of Rac proteins

12 July 2018

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Hydrogen sulphide--a novel mediator of inflammation?

12 July 2018

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Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

The chemokine system in diverse forms of macrophage activation and polarization

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer's disease: a systematic review

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

S100B causes apoptosis in a myoblast cell line in a RAGE-independent manner.

12 July 2018

1 reference

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RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.

12 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).

12 July 2018

1 reference

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Protein engineering and properties of human metalloproteinase and thrombospondin 1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study

12 July 2018

1 reference

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Expression and regulation of aggrecanase in arthritis: the role of TGF-beta

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Initial sequencing and analysis of the human genome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Atypical neural messengers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Expression of coxsackievirus and adenovirus receptor in hearts of rats with experimental autoimmune myocarditis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Sympathetic neurons can produce and respond to interleukin 6

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Glial-neuronal interactions in Alzheimer's disease: the potential role of a 'cytokine cycle' in disease progression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Mammalian type I interferon receptors consists of two subunits: IFNaR1 and IFNaR2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Interleukin-6 (IL-6)--a molecule with both beneficial and destructive potentials

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

TGF-beta in kidney fibrosis: a target for gene therapy

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Increased central nervous system production of extracellular matrix components and development of hydrocephalus in transgenic mice overexpressing transforming growth factor-beta 1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Altered expression of transforming growth factor-beta in Alzheimer's disease.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Anti-interferon immunoglobulins can improve the trisomy 16 mouse phenotype.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Purification and characterization of a neurite extension factor from bovine brain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Analysis of the calcium-modulated proteins, S100 and calmodulin, and their target proteins during C6 glioma cell differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

A prospective study of Alzheimer disease in Down syndrome.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Macrophages and microglia in the nervous system

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Neurotrophic activity of S-100 beta in cultures of dorsal root ganglia from embryonic chick and fetal rat.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Neurotrophic protein S100 beta stimulates glial cell proliferation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Interleukin-6 and leukemia inhibitory factor promote the survival of acetylcholinesterase-positive neurons in culture from embryonic rat spinal cord

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrains

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Studies on the catabolism of NG-methylarginine, NG, NG-dimethylarginine and NG, NG-dimethylarginine in the rabbit

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Some aspects of amoeboid microglia in the corpus callosum and neighbouring regions of neonatal rats

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Comorbidity, hospitalization, and medication use and their influence on mental and motor development of young infants with Down syndrome.

12 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

A four year prospective study of age-related cognitive change in adults with Down's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Prevalence of dementia and impact on intellectual disability services.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Human brain S100 beta and S100 beta mRNA expression increases with age: pathogenic implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Increased serum IL-1beta level in Alzheimer's disease and mild cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Restraining tumor necrosis factor-alpha by thalidomide prevents the amyloid beta-induced impairment of recognition memory in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Decrease of TGF-beta1 plasma levels and increase of nitric oxide synthase activity in leukocytes as potential biomarkers of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

The coxsackie-adenovirus receptor induces an inflammatory cardiomyopathy independent of viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

RIP4 regulates epidermal differentiation and cutaneous inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Effects of vitamin E on oxidative stress and membrane fluidity in brain of streptozotocin-induced diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part I).

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3290800

Triple-Marker Prenatal Screening Program for Chromosomal Defects

25 September 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F170276

Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine

21 January 2018

1 reference

12 December 2020

The prevalence of dementia in Down syndrome

1 reference

12 December 2020

On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases

1 reference

12 December 2020

Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures

1 reference

12 December 2020

Improved national prevalence estimates for 18 selected major birth defects--United States, 1999-2001

1 reference

12 December 2020

Immunotherapy for multiple sclerosis: from theory to practice

1 reference

12 December 2020

Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain

1 reference

12 December 2020

Recombinant human IL-6 suppresses demyelination in a viral model of multiple sclerosis

1 reference

12 December 2020

Partial IFN-alpha/beta and IFN-gamma receptor knockout trisomy 16 mouse fetuses show improved growth and cultured neuron viability

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/170276

1 reference

10 August 2017

1 reference

10 August 2017

1 reference