(Q35797031)

10 August 2017

title

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase (English)

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10 August 2017

5

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10 August 2017

A B Satterthwaite

1

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10 August 2017

F Willis

2

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10 August 2017

P Kanchanastit

3

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10 August 2017

D Fruman

4

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10 August 2017

C D Helgason

6

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10 August 2017

R K Humphries

7

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10 August 2017

C A Lowell

8

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10 August 2017

M Simon

9

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10 August 2017

M Leitges

10

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10 August 2017

A Tarakhovsky

11

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10 August 2017

T F Tedder

12

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10 August 2017

R Lesche

13

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10 August 2017

H Wu

14

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10 August 2017

O N Witte

15

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10 August 2017

language of work or name

English

0 references

publication date

1 June 2000

1 reference

Proceedings of the National Academy of Sciences of the United States of America

10 August 2017

published in

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10 August 2017

volume

97

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10 August 2017

issue

12

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10 August 2017

page(s)

6687-6692

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A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice

10 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Pten is essential for embryonic development and tumour suppression

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

SHIP modulates immune receptor responses by regulating membrane association of Btk.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Random mutagenesis screen for dominant behavioral mutations in mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Btk dosage determines sensitivity to B cell antigen receptor cross-linking

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Genetic identification of two major modifier loci of polycystic kidney disease progression in pcy mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Role of Btk in B cell development and signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

The complexity of signaling pathways activated by the BCR.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

CD22 is a negative regulator of B-cell receptor signalling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

CD22 regulates thymus-independent responses and the lifespan of B cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Hyperresponsive B cells in CD22-deficient mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

A screen for genes that function downstream of Ras1 during Drosophila eye development.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Immunodeficiency in protein kinase cbeta-deficient mice

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Discordant phenotype in siblings with X-linked agammaglobulinemia

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Regulation of Btk function by a major autophosphorylation site within the SH3 domain

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Involvement of p59fynT in interleukin-5 receptor signaling

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

T cell-independent antigens type 2.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Synergistic genetic defect in B-lymphocyte function. I. Defective responses to B-cell stimulants and their genetic basis

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

27 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Btk function in B cell development and response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

A Btk transgene restores the antiviral TI-2 antibody responses of xid mice in a dose-dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Defective platelet activation in G alpha(q)-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Constitutive membrane association potentiates activation of Bruton tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Inhibition of the B cell by CD22: a requirement for Lyn

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=18703

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

25 September 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Counterregulation by the Coreceptors CD19 and CD22 of MAP Kinase Activation by Membrane Immunoglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Epistatic modifiers of autoimmunity in a murine model of lupus nephritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

X-linked immune deficiency (xid) of CBA/N mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Impaired Fas response and autoimmunity in Pten+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.110146697

Surface IgM-stimulated proliferation, inositol phospholipid hydrolysis, Ca2+ flux, and tyrosine phosphorylation are not altered in B cells from p59fyn-1- mice

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10829070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.110146697

1 reference

10 August 2017

0 references

1 reference

10 August 2017

1 reference