(Q35800291)

English

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

scientific article published on 22 January 2014

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors (English)

1 reference

Europe PubMed Central

10 August 2017

author name string

Edward Sausville

1

1 reference

Europe PubMed Central

10 August 2017

Patricia Lorusso

2

1 reference

Europe PubMed Central

10 August 2017

Michael Carducci

3

1 reference

Europe PubMed Central

10 August 2017

Judith Carter

4

1 reference

Europe PubMed Central

10 August 2017

Mary F Quinn

5

1 reference

Europe PubMed Central

10 August 2017

Lisa Malburg

6

1 reference

Europe PubMed Central

10 August 2017

Nilofer Azad

7

1 reference

Europe PubMed Central

10 August 2017

David Cosgrove

8

1 reference

Europe PubMed Central

10 August 2017

Richard Knight

9

1 reference

Europe PubMed Central

10 August 2017

Peter Barker

10

1 reference

Europe PubMed Central

10 August 2017

Sonya Zabludoff

11

1 reference

Europe PubMed Central

10 August 2017

Felix Agbo

12

1 reference

Europe PubMed Central

10 August 2017

Patricia Oakes

13

1 reference

Europe PubMed Central

10 August 2017

Adrian Senderowicz

14

1 reference

Europe PubMed Central

10 August 2017

publication date

22 January 2014

1 reference

Europe PubMed Central

10 August 2017

Cancer Chemotherapy and Pharmacology

1 reference

Europe PubMed Central

10 August 2017

73

1 reference

Europe PubMed Central

10 August 2017

539-549

1 reference

Europe PubMed Central

10 August 2017

3

1 reference

Europe PubMed Central

10 August 2017

https://scigraph.springernature.com/pub.10.1007/s00280-014-2380-5

0 references

Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

27 July 2018

Phase I and pharmacologic trial of cytosine arabinoside with the selective checkpoint 1 inhibitor Sch 900776 in refractory acute leukemias.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

27 July 2018

CaMKII in the cardiovascular system: sensing redox states.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

27 July 2018

In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

27 July 2018

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

27 July 2018

Inhibition of CDKs as a therapeutic modality.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

27 July 2018

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

27 July 2018

New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

27 July 2018

Anticancer drug targets: cell cycle and checkpoint control.

1 reference

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27 July 2018

Maintaining genetic stability through TP53 mediated checkpoint control.

1 reference

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27 July 2018

Mechanism by which caffeine potentiates lethality of nitrogen mustard

1 reference

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27 July 2018

The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae

1 reference

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27 July 2018

Checkpoints: controls that ensure the order of cell cycle events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

27 July 2018

The α2Na+/K+-ATPase is critical for skeletal and heart muscle function in zebrafish

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

25 September 2018

"The Octet": Eight Protein Kinases that Control Mammalian DNA Replication.

1 reference

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25 September 2018

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

25 September 2018

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

25 September 2018

BCL2 family in DNA damage and cell cycle control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

25 September 2018

Structural basis for Chk1 inhibition by UCN-01

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

25 September 2018

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

25 September 2018

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

25 September 2018

Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

25 September 2018

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4486055

25 September 2018

Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/24448638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/24448638

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00280-014-2380-5

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

10 August 2017

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