(Q35804457)

10 August 2017

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title

The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? (English)

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10 August 2017

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Sergio Romagnani

1

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10 August 2017

publication date

1 July 2004

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10 August 2017

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10 August 2017

volume

112

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10 August 2017

issue

3

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10 August 2017

page(s)

352-363

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The role of lymphocytes in allergic disease

10 August 2017

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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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A novel transcription factor, T-bet, directs Th1 lineage commitment

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Natural versus adaptive regulatory T cells

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Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells

21 January 2018

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Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study

21 January 2018

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Multiple sclerosis epidemiology in Sardinia: evidence for a true increasing risk.

21 January 2018

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ReviewDoes the “Hygiene Hypothesis” Provide an Explanation for the High Prevalence of Multiple Sclerosis in Sardinia?

21 January 2018

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Declining incidence of multiple sclerosis in the Orkney Islands

21 January 2018

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A critical review of epidemiological studies in inflammatory bowel disease

21 January 2018

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Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections.

21 January 2018

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Reduced incidence and prevalence of atopy in rheumatoid arthritis. Results of a case-control study

21 January 2018

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Th2 mediated regulation in RA and the spondyloarthropathies

21 January 2018

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Asthma and multiple sclerosis: an inverse association in a case-control general practice population.

21 January 2018

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Hypothesis: dysregulation of immunologic balance resulting from hygiene and socioeconomic factors may influence the epidemiology and cause of glomerulonephritis worldwide

21 January 2018

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Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells

21 January 2018

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Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity

21 January 2018

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Reversal of human allergen-specific CRTH2+ T(H)2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotide.

21 January 2018

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The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells.

21 January 2018

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Is Th1 the solution for Th2 in asthma?

21 January 2018

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21 January 2018

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21 January 2018

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Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse

21 January 2018

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21 January 2018

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21 January 2018

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The effect of neonatal BCG vaccination on atopy and asthma at age 7 to 14 years: an historical cohort study in a community with a very low prevalence of tuberculosis infection and a high prevalence of atopic disease

21 January 2018

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Lactic acid bacteria inhibit TH2 cytokine production by mononuclear cells from allergic patients.

21 January 2018

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Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Influenza A Virus Infection Inhibits the Efficient Recruitment of Th2 Cells into the Airways and the Development of Airway Eosinophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Immunologic influences on allergy and the TH1/TH2 balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

GATA-3 in human T cell helper type 2 development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

T(H)1/T(H)2 immune response profiles differ between atopic children in eastern and western Germany.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

House dust endotoxin and allergic sensitization in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Expression of CD14 and Toll-like receptor 2 in farmers' and nonfarmers' children

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

CD4+CD25+ T cells regulate airway eosinophilic inflammation by modulating the Th2 cell phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

T regulatory cells 1 inhibit a Th2-specific response in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Interleukin-10, T regulatory cells and specific allergy treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Generation and regulation of human Th1-biased immune responses in vivo: a critical role for IL-4 and IL-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Immunotherapeutic uses of CpG oligodeoxynucleotides

21 January 2018

1 reference

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The effect of BCG vaccine at birth on the development of atopy or allergic disease in young children

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

IL-10 is critical for Th2 responses in a murine model of allergic dermatitis

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

Prevention of Der p2-induced allergic airway inflammation by Mycobacterium-bacillus Calmette Guerin

15 November 2018

1 reference

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CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

The role of allergy in the development of asthma

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation

15 November 2018

1 reference

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Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-gamma over IL-4 responses

15 November 2018

1 reference

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CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy.

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

Nebulized IFN-gamma inhibits the development of secondary allergic responses in mice.

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

Lymphokine production by human T cells in disease states

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

Allergic reactivity and socio-economic level in a tropical environment.

15 November 2018

1 reference

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Hay fever, hygiene, and household size

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

Functional subsets of allergen-reactive human CD4+ T cells

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones

15 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1782506

Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

15 November 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Neonatal interleukin-12 capacity is associated with variations in allergen-specific immune responses in the neonatal and postnatal periods

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2567.2004.01925.X

Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice

21 January 2018

1 reference

12 December 2020

Phosphorothioate oligodeoxynucleotides promote the in vitro development of human allergen-specific CD4+ T cells into Th1 effectors

1 reference

12 December 2020

CD4 CD25 regulatory T cells are not functionally impaired in adult patients with IgE-mediated cow's milk allergy

1 reference

12 December 2020

Experimental Leishmania major infection in mice: role of IL-10

1 reference

12 December 2020

Systemic and local interferon gamma gene delivery to the lungs for treatment of allergen-induced airway hyperresponsiveness in mice

1 reference

12 December 2020

Role of CD4(+) CD25(+) regulatory T cells in T helper 2 cell-mediated allergic inflammation in the airways

1 reference

12 December 2020

Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells

1 reference

12 December 2020

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

1 reference

12 December 2020

Dendritic cells contribute to the development of atopy by an insufficiency in IL-12 production

1 reference

12 December 2020

Application of heat killed Mycobacterium bovis-BCG into the lung inhibits the development of allergen-induced Th2 responses

1 reference

12 December 2020

Polyclonal and allergen-induced cytokine responses in adults with asthma: resolution of asthma is associated with normalization of IFN-gamma responses

1 reference

12 December 2020

Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loop

1 reference

12 December 2020

Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma

1 reference

12 December 2020

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones

1 reference

12 December 2020

Nebulized but not parenteral IFN-gamma decreases IgE production and normalizes airways function in a murine model of allergen sensitization

1 reference

12 December 2020

The effects of nebulized recombinant interferon-gamma in asthmatic airways

1 reference

12 December 2020

Polyinosinic acid: polycytidylic acid promotes T helper type 1-specific immune responses by stimulating macrophage production of interferon-alpha and interleukin-12

1 reference

12 December 2020

Regulation of disease susceptibility: decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis

1 reference

12 December 2020

Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice

1 reference

12 December 2020

Reduced prevalence of allergic disease in patients with multiple sclerosis is associated with enhanced IL-12 production

1 reference

12 December 2020

Gene expression of the GATA-3 transcription factor is increased in atopic asthma

1 reference

12 December 2020

10.1111/J.1365-2567.2004.01925.X

Identifiers

DOI

1 reference

10 August 2017

0 references

1 reference