(Q35814460)

10 August 2017

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title

Development of pro-angiogenic engineered transcription factors for the treatment of cardiovascular disease (English)

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10 August 2017

1

Edward J Rebar

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10 August 2017

language of work or name

English

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publication date

1 July 2004

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Expert Opinion on Investigational Drugs

10 August 2017

published in

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10 August 2017

volume

13

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10 August 2017

issue

7

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10 August 2017

page(s)

829-839

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Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes

10 August 2017

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Angiogenesis Induced by Endothelial Nitric Oxide Synthase Gene Through Vascular Endothelial Growth Factor Expression in a Rat Hindlimb Ischemia Model

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Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat and rabbit hindlimb ischemia models: preclinical study for treatment of peripheral arterial disease

21 January 2018

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Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart

21 January 2018

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Gene therapy with adenovirus-mediated myocardial transfer of vascular endothelial growth factor 121 improves cardiac performance in a pacing model of congestive heart failure

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Gene therapy for cardiovascular angiogenesis

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Therapeutic angiogenesis in cardiovascular disease

21 January 2018

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Safety and Feasibility of Catheter-Based Local Intracoronary Vascular Endothelial Growth Factor Gene Transfer in the Prevention of Postangioplasty and In-Stent Restenosis and in the Treatment of Chronic Myocardial Ischemia

21 January 2018

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A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina

21 January 2018

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Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study

21 January 2018

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Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial

21 January 2018

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Pharmacological treatment of coronary artery disease with recombinant fibroblast growth factor-2: double-blind, randomized, controlled clinical trial

21 January 2018

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Rescue of hypercholesterolemia-related impairment of angiogenesis by oral folate supplementation

21 January 2018

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Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines.

21 January 2018

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Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo.

21 January 2018

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21 January 2018

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21 January 2018

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Molecular regulation of vessel maturation

21 January 2018

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21 January 2018

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Role of vascular endothelial growth factor in the regulation of angiogenesis

21 January 2018

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VEGF162, a new heparin-binding vascular endothelial growth factor splice form that is expressed in transformed human cells

21 January 2018

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21 January 2018

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Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature.

21 January 2018

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Ligand-dependent regulation of plasmid-based transgene expression in vivo

21 January 2018

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Regulation of endogenous gene expression with a small-molecule dimerizer

21 January 2018

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Modular structure of transcription factors: implications for gene regulation

21 January 2018

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Tissue-specific expression of an anti-proliferative hybrid transgene from the human smooth muscle alpha-actin promoter suppresses smooth muscle cell proliferation and neointima formation

21 January 2018

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Conditional expression of a dominant-negative c-Myb in vascular smooth muscle cells inhibits arterial remodeling after injury

21 January 2018

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Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

21 January 2018

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

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Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1.

21 January 2018

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GAL4-VP16 is an unusually potent transcriptional activator

21 January 2018

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Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression

21 January 2018

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Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1.

21 January 2018

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Hypoxia up-regulates expression of peroxisome proliferator-activated receptor gamma angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1alpha

21 January 2018

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Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors

21 January 2018

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Gene expression profiles in human cardiac cells subjected to hypoxia or expressing a hybrid form of HIF-1 alpha

21 January 2018

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Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat.

21 January 2018

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Design and selection of novel Cys2His2 zinc finger proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Sequence-specific recognition of double helical nucleic acids by proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

DNA binding site of the growth factor-inducible protein Zif268

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins

21 January 2018

1 reference

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Zinc finger phage: affinity selection of fingers with new DNA-binding specificities

21 January 2018

1 reference

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In vitro selection of zinc fingers with altered DNA-binding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage

21 January 2018

1 reference

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A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions

21 January 2018

1 reference

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Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Induction of angiogenesis in a mouse model using engineered transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Positive and negative regulation of endogenous genes by designed transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Engineered zinc finger proteins for controlling stem cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Design of artificial transcription factors to selectively regulate the pro-apoptotic bax gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Scanning the human genome with combinatorial transcription factor libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Contribution of the Per/Arnt/Sim (PAS) domains to DNA binding by the basic helix-loop-helix PAS transcriptional regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.829

10.1517/13543784.13.7.829

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference