(Q35816898)

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Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells.

scientific article published in October 2015

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27 February 2020

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells (English)

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27 February 2020

Human Induced Pluripotent Stem Cells

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neurodegeneration

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author name string

Marija Usenovic

1

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27 February 2020

Shahriar Niroomand

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27 February 2020

Robert E Drolet

3

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27 February 2020

Lihang Yao

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27 February 2020

Renee C Gaspar

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27 February 2020

Nathan G Hatcher

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27 February 2020

Joel Schachter

7

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27 February 2020

John J Renger

8

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27 February 2020

Sophie Parmentier-Batteur

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27 February 2020

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1 October 2015

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27 February 2020

Journal of Neuroscience

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27 February 2020

35

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27 February 2020

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27 February 2020

14234-14250

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27 February 2020

[18] Quantification of β-sheet amyloid fibril structures with thioflavin T

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https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Quantification of protein-protein interactions using fluorescence polarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Conformational change as one of the earliest alterations of tau in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau aggregation in the hippocampal formation: an ageing or a pathological process?

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Fluorescence polarization: past, present and future

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The calpains in aging and aging-related diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic animal models of tauopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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A microfluidic culture platform for CNS axonal injury, regeneration and transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin alleviates toxicity of different aggregate-prone proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoassays with direct mass spectrometric detection

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Characteristics of the binding of thioflavin S to tau paired helical filaments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Characterization of two VQIXXK motifs for tau fibrillization in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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The distribution of synapsin I and synaptophysin in hippocampal neurons developing in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Propagation of tau misfolding from the outside to the inside of a cell.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Transmission and spreading of tauopathy in transgenic mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Reactivity and applications of new amine reactive cross-linkers for mass spectrometric detection of protein-protein complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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The dysregulation of intracellular calcium in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Autophagy in protein and organelle turnover

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Propagation of tau pathology in a model of early Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trans-cellular propagation of Tau aggregation by fibrillar species

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Constitutive secretion of tau protein by an unconventional mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Biochemistry and cell biology of tau protein in neurofibrillary degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Characterizing human ion channels in induced pluripotent stem cell-derived neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Guidelines for the use and interpretation of assays for monitoring autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Cellular mechanisms of protein aggregate propagation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Physiological release of endogenous tau is stimulated by neuronal activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Brain homogenates from human tauopathies induce tau inclusions in mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Fluorescence Polarization (FP) Assays for Monitoring Peptide-Protein or Nucleic Acid-Protein Binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Formation and propagation of tau oligomeric seeds

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Intercellular transfer of tau aggregates and spreading of tau pathology: Implications for therapeutic strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against α-synuclein-induced synapse damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Conformation determines the seeding potencies of native and recombinant Tau aggregates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin ester analog CCI-779/Temsirolimus alleviates tau pathology and improves motor deficit in mutant tau transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

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Staging of Alzheimer's disease-related neurofibrillary changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

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Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26490863

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1523-15.2015

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Europe PubMed Central

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27 February 2020

release_lv255z4f3vd23m4hfed3oh6qwm

1 reference

https://api.fatcat.wiki/v0/release/lv255z4f3vd23m4hfed3oh6qwm

24 November 2022

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Europe PubMed Central

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27 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26490863%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

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