(Q35548609)

8 August 2017

1 reference

title

The calpains in aging and aging-related diseases (English)

1 reference

8 August 2017

Ralph A Nixon

1

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8 August 2017

1 October 2003

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8 August 2017

Ageing Research Reviews

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8 August 2017

2

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8 August 2017

4

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8 August 2017

407-418

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P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein.

8 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Signal convergence on protein kinase A as a molecular correlate of learning

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Age-dependent degradation of calpastatin in kidney of hypertensive rats

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Involvement of calpain in diamide-induced cataract in cultured lenses

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain II in two in vivo models of sugar cataract

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain inhibitors, a treatment for Alzheimer's disease: position paper

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Low levels of calpain activity in Chiroptera brain: implications for mechanisms of aging

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Is the senescent heart overloaded and already failing?

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain: a protease in search of a function?

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain and mitochondria in ischemia/reperfusion injury

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calcium-activated neutral protease (calpain) system: structure, function, and regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

When lysosomes get old.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain II induced insolubilization of lens beta-crystallin polypeptides may induce cataract

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Autolysis, Ca2+Requirement, and Heterodimer Stability in m-Calpain

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Cutting to the chase: calpain proteases in cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin?

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Structure of the beta-glucosidase gene bglA of Clostridium thermocellum. Sequence analysis reveals a superfamily of cellulases and beta-glycosidases including human lactase/phlorizin hydrolase

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

The calpain family and human disease

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain from rat intestinal epithelial cells: age-dependent dynamics during cell differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR).

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain II activity and calpastatin content in brain regions of 3- and 24-month-old rats.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Cellular signaling pathways and cytoskeletal organization.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

p44mpk MAP kinase induces Alzheimer type alterations in tau function and in primary hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Lp82 is the dominant form of calpain in young mouse lens

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Klotho protein deficiency leads to overactivation of mu-calpain

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Amyloid precursor protein family-induced neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Interaction of human erythrocyte multicatalytic proteinase with polycations

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Modulation of the calpain autoproteolysis by calpastatin and phospholipids

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

The calpain-calpastatin system in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

A Ca(2+) switch aligns the active site of calpain

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Fragmentation of an endogenous inhibitor upon complex formation with high- and low-Ca2+-requiring forms of calcium-activated neutral proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Studies and perspectives of protein kinase C.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Phosphorylation and proteolytic modification of specific cytoskeletal proteins in human neutrophils stimulated by phorbol 12-myristate 13-acetate

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Filopodial calcium transients regulate growth cone motility and guidance through local activation of calpain.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calcium pump phosphoenzyme from young and old human red cells

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Site-directed activation of calpain is promoted by a membrane-associated natural activator protein

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain function in the modulation of signal transduction molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain regulation of integrin alpha IIb beta 3 signaling in human platelets

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Band 3 protein degradation by calpain is enhanced in erythrocytes of old people

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpastatin in erythrocytes of young and old individuals

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpains mediate p53 activation and neuronal death evoked by DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Enhancement of neurite outgrowth following calpain inhibition is mediated by protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calcium influx into human neuroblastoma cells induces ALZ-50 immunoreactivity: involvement of calpain-mediated hydrolysis of protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Age-dependent myelin degeneration and proteolysis of oligodendrocyte proteins is associated with the activation of calpain-1 in the rhesus monkey.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain inhibitors block Ca(2+)-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

The structure of calpain.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Prolonged nuclear retention of activated extracellular signal-regulated protein kinase promotes cell death generated by oxidative toxicity or proteasome inhibition in a neuronal cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

A novel aspect of calpain activation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Autolysis of Calcium-Activated Neutral Protease of Chicken Skeletal Muscle1

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Activation of a calmodulin-dependent phosphatase by a Ca2+-dependent protease

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Trophic agents that prevent neuronal apoptosis activate calpain and down-regulate CaMKIV.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Changes in intracellular localization of calpastatin during calpain activation

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calcium-activated neutral proteinase of human brain: subunit structure and enzymatic properties of multiple molecular forms.

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calpain and caspase: can you tell the difference?

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Bax cleavage is mediated by calpain during drug-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Calcium-dependent cysteine proteinase (calpain) in human arthritic synovial joints

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

Limited proteolysis of bovine lens α-crystallin by calpain, A Ca2+-dependent cysteine proteinase, isolated from the same tissue

1 reference

https://api.crossref.org/works/10.1016%2FS1568-1637%2803%2900029-1

7 January 2021

10.1016/S1568-1637(03)00029-1

Identifiers

DOI

1 reference

8 August 2017

1 reference

PubMed ID

14522243