(Q35828757)

English

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

scientific article published on 13 February 2007

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scholarly article

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Europe PubMed Central

PMC publication ID

10 August 2017

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin (English)

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Europe PubMed Central

PMC publication ID

10 August 2017

ineffective erythropoiesis

1 reference

based on heuristic

inferred from title

beta thalassemia

1 reference

based on heuristic

inferred from title

14

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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Laura Breda

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Stefano Rivella

object named as

Stefano Rivella

18

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object named as

Maria de Sousa

15

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Patricia J Giardina

16

object named as

Patricia J Giardina

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Europe PubMed Central

PMC publication ID

10 August 2017

Ninette Amariglio

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object named as

Ninette Amariglio

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Europe PubMed Central

PMC publication ID

10 August 2017

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object named as

Gideon Rechavi

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Europe PubMed Central

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10 August 2017

1

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Sara Gardenghi

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Europe PubMed Central

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10 August 2017

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object named as

Ella Guy

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Europe PubMed Central

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10 August 2017

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Amy Chadburn

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Europe PubMed Central

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10 August 2017

author name string

Maria F Marongiu

2

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10 August 2017

Pedro Ramos

3

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Europe PubMed Central

PMC publication ID

10 August 2017

YiFang Liu

7

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Europe PubMed Central

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10 August 2017

Eliezer A Rachmilewitz

10

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Europe PubMed Central

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10 August 2017

William Breuer

11

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Europe PubMed Central

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10 August 2017

Z Ioav Cabantchik

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Europe PubMed Central

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10 August 2017

Diedra M Wrighting

13

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10 August 2017

Robert W Grady

17

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10 August 2017

language of work or name

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publication date

13 February 2007

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Europe PubMed Central

PMC publication ID

10 August 2017

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

109

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10 August 2017

11

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10 August 2017

5027-5035

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Hepcidin--a peptide hormone at the interface of innate immunity and iron metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Interleukin-6 induces hepcidin expression through STAT3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Inherited hemochromatosis: from genetics to clinics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

A mouse model of juvenile hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

The molecular basis of ferroportin-linked hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Molecular control of iron metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Hepcidin in iron overload disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Labile plasma iron (LPI) as an indicator of chelatable plasma redox activity in iron-overloaded beta-thalassemia/HbE patients treated with an oral chelator

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

The ferroportin disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Pathophysiology of thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Chelation therapy in beta-thalassemia: an optimistic update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

HFE gene knockout produces mouse model of hereditary hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

A mouse model for beta 0-thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Ferrokinetics in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Twenty-four hour variation of transferrin saturation in treated and untreated haemochromatosis homozygotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

27 July 2018

Liver expression of hepcidin and other iron genes in two mouse models of beta-thalassemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Suppression of hepcidin during anemia requires erythropoietic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Hepcidin is decreased in TFR2 hemochromatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Labile plasma iron in iron overload: redox activity and susceptibility to chelation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Juvenile hemochromatosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Ineffective erythropoiesis in beta-thalassemia major is due to apoptosis at the polychromatophilic normoblast stage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with beta-thalassemia major.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885515

24 September 2018

HFE cross-talks with the MHC class I antigen presentation pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of enterocyte iron accumulation in the ferroportin disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mRNA expression of iron regulatory genes in β-thalassemia intermedia and β-thalassemia major mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of ferroportin in hemochromatosis liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased hepcidin mRNA expression in thalassemic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thalassemia intermedia, with iron overload, cardiac failure, diabetes mellitus, hypopituitarism and porphyrinuria

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption of inorganic and food iron in children with heterozygous and homozygous ?-thalassemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The identification of 2, 3-dihydroxybenzoic acid as a potentially useful iron-chelating drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron overload and desferrioxamine chelation therapy in beta-thalassemia intermedia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mouse model for β-thalassemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compensatory increase in levels of beta minor globin in murine beta-thalassemia is under translational control

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron metabolism in thalassemia intermedia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17299088

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1182/BLOOD-2006-09-048868

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

0 references

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