(Q35852284)

10 August 2017

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title

HIV and SIV CTL escape: implications for vaccine design (English)

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10 August 2017

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2

David I Watkins

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10 August 2017

Philip J R Goulder

1

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10 August 2017

language of work or name

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1 August 2004

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Nature Reviews Immunology

10 August 2017

published in

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10 August 2017

volume

4

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10 August 2017

issue

8

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10 August 2017

page(s)

630-640

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Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

10 August 2017

cites work

1 reference

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

21 January 2018

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Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors

21 January 2018

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21 January 2018

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Effect of a single amino acid change in MHC class I molecules on the rate of progression to AIDS

21 January 2018

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Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

21 January 2018

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Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition

21 January 2018

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Modest Briton stirs up storm with views on role of CTLs.

21 January 2018

1 reference

Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus

21 January 2018

1 reference

Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection

21 January 2018

1 reference

Definition of five new simian immunodeficiency virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression.

21 January 2018

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Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.

21 January 2018

1 reference

Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia

21 January 2018

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Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection

21 January 2018

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Extraepitopic compensatory substitutions partially restore fitness to simian immunodeficiency virus variants that escape from an immunodominant cytotoxic-T-lymphocyte response

21 January 2018

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Simian-human immunodeficiency virus escape from cytotoxic T-lymphocyte recognition at a structurally constrained epitope.

21 January 2018

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Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys

21 January 2018

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Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes

21 January 2018

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Triple therapy in the eradication of Helicobacter pylori in patients with duodenal ulcer disease: results of a multicentre study in South-East Asia. South-East Asia Multicenter Study Group.

21 January 2018

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Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.

21 January 2018

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Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid

21 January 2018

1 reference

Reversion of CTL escape–variant immunodeficiency viruses in vivo

21 January 2018

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HIV evolution: CTL escape mutation and reversion after transmission

21 January 2018

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ALVAC-SIV-gag-pol-env-based vaccination and macaque major histocompatibility complex class I (A*01) delay simian immunodeficiency virus SIVmac-induced immunodeficiency

21 January 2018

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Mamu-A*01 allele-mediated attenuation of disease progression in simian-human immunodeficiency virus infection

21 January 2018

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Expression of the major histocompatibility complex class I molecule Mamu-A*01 is associated with control of simian immunodeficiency virus SIVmac239 replication

21 January 2018

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Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant acute-phase cytotoxic-T-lymphocyte responses

21 January 2018

1 reference

Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection

21 January 2018

1 reference

The differential ability of HLA B*5701+ long-term nonprogressors and progressors to restrict human immunodeficiency virus replication is not caused by loss of recognition of autologous viral gag sequences

21 January 2018

1 reference

Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trial

21 January 2018

1 reference

Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection

21 January 2018

1 reference

Patterns of immunodominance in HIV-1-specific cytotoxic T lymphocyte responses in two human histocompatibility leukocyte antigens (HLA)-identical siblings with HLA-A*0201 are influenced by epitope mutation.

21 January 2018

1 reference

A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape.

21 January 2018

1 reference

Determinant of HIV-1 mutational escape from cytotoxic T lymphocytes

21 January 2018

1 reference

Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL

21 January 2018

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Impact of antigen expression kinetics on the effectiveness of HIV-specific cytotoxic T lymphocytes.

21 January 2018

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Evolution and transmission of stable CTL escape mutations in HIV infection

21 January 2018

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Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants

21 January 2018

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Antagonists or altruists: do viral mutants modulate T-cell responses?

21 January 2018

1 reference

Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection

21 January 2018

1 reference

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection

21 January 2018

1 reference

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

21 January 2018

1 reference

Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infection

21 January 2018

1 reference

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

21 January 2018

1 reference

Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.

21 January 2018

1 reference

The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

21 January 2018

1 reference

Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV.

21 January 2018

1 reference

Skewed maturation of memory HIV-specific CD8 T lymphocytes

21 January 2018

1 reference

Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection

21 January 2018

1 reference

Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda

21 January 2018

1 reference

Stochastic simulation of the impact of antiretroviral therapy and HIV vaccines on HIV transmission; Rakai, Uganda

21 January 2018

1 reference

Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. Women and Infants Transmission Study Group

21 January 2018

1 reference

HIV vaccine design and the neutralizing antibody problem

21 January 2018

1 reference

Immunodominance in major histocompatibility complex class I-restricted T lymphocyte responses

21 January 2018

1 reference

Will we be able to 'spot' an effective HIV-1 vaccine?

21 January 2018

1 reference

Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency

21 January 2018

1 reference

Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes

21 January 2018

1 reference

Broadly Increased Sensitivity to Cytotoxic T Lymphocytes Resulting from Nef Epitope Escape Mutations

21 January 2018

1 reference

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus

21 January 2018

1 reference

Immunodominance in virus-induced CD8(+) T-cell responses is dramatically modified by DNA immunization and is regulated by gamma interferon

21 January 2018

1 reference

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

21 January 2018

1 reference

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

21 January 2018

1 reference

Novel, cross-restricted, conserved, and immunodominant cytotoxic T lymphocyte epitopes in slow progressors in HIV type 1 infection

31 March 2020

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HLA and AIDS: a cautionary tale

31 March 2020

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HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

31 March 2020

1 reference

In vivo persistence of a HIV-1-encoded HLA-B27-restricted cytotoxic T lymphocyte epitope despite specificin vitro reactivity

31 March 2020

1 reference

Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression

31 March 2020

1 reference

Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level

31 March 2020

1 reference

Direct visualization of HIV-1-specific cytotoxic T lymphocytes during primary infection.

31 March 2020

1 reference

Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection

31 March 2020

1 reference

HIV/AIDS. HLA leaves its footprints on HIV

31 March 2020

1 reference

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

31 March 2020

1 reference

Expression kinetics and subcellular localization of HIV-1 regulatory proteins Nef, Tat and Rev in acutely and chronically infected lymphoid cell lines

31 March 2020

1 reference

Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes

31 March 2020

1 reference

Competition Between CTL Narrows the Immune Response Induced by Prime-Boost Vaccination Protocols

31 March 2020

1 reference

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Lack of viral escape and defective in vivo activation of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes in rapidly progressive infection

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Kinetics of antiviral activity by human immunodeficiency virus type 1-specific cytotoxic T lymphocytes (CTL) and rapid selection of CTL escape virus in vitro.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Quantifying the uncertainty in forecasts of anthropogenic climate change

1 reference

27 September 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/35036559

Identifiers

DOI

10.1038/NRI1417

1 reference

10 August 2017

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