(Q35852304)

10 August 2017

1 reference

title

Lipid metabolic enzymes: emerging drug targets for the treatment of obesity (English)

1 reference

10 August 2017

0 references

1 reference

Yuguang Shi

1

1 reference

10 August 2017

Paul Burn

series ordinal

2

1 reference

10 August 2017

language of work or name

1 reference

1 August 2004

1 reference

Nature Reviews Drug Discovery

10 August 2017

published in

1 reference

10 August 2017

volume

3

1 reference

10 August 2017

issue

8

1 reference

10 August 2017

page(s)

695-710

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd1469

10 August 2017

exact match

0 references

cites work

Importance of lipolysis in oral cavity for orosensory detection of fat

1 reference

Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity

21 January 2018

1 reference

Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice

21 January 2018

1 reference

21 January 2018

1 reference

Pancreatic phospholipase A(2): new views on old issues.

21 January 2018

1 reference

Structure-based design of a new class of anti-inflammatory drugs: secretory phospholipase A(2) inhibitors, SPI.

21 January 2018

1 reference

Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity

21 January 2018

1 reference

Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1.

21 January 2018

1 reference

Mobilisation of triacylglycerol stores

21 January 2018

1 reference

Mammalian mitochondrial glycerol-3-phosphate acyltransferase

21 January 2018

1 reference

C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity

21 January 2018

1 reference

Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation

21 January 2018

1 reference

Herbicides inhibiting acetyl-CoA carboxylase

21 January 2018

1 reference

Strategies and potential molecular targets for obesity treatment

21 January 2018

1 reference

Gastric and pancreatic lipase levels during a test meal in dogs

31 March 2020

1 reference

An examination of the factors affecting intestinal lymphatic transport of dietary lipids

31 March 2020

1 reference

Digestive lipases: from three-dimensional structure to physiology

31 March 2020

1 reference

Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans

31 March 2020

1 reference

Binding of pancreatic colipase to interfaces; effects of detergents

31 March 2020

1 reference

Effect of a satiating meal on the concentrations of procolipase propeptide in the serum and urine of normal and morbidly obese subjects

31 March 2020

1 reference

Screening of lipase inhibitors from marine algae

31 March 2020

1 reference

Long-term systemic exposure of orlistat, a lipase inhibitor, and its metabolites in obese patients

31 March 2020

1 reference

Effect of orlistat added to diet (30% of calories from fat) on plasma lipids, glucose, and insulin in obese patients with hypercholesterolemia

31 March 2020

1 reference

Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials

31 March 2020

1 reference

The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo-controlled trial

31 March 2020

1 reference

Lipid Digestion and Absorption

31 March 2020

1 reference

Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A(2)-deficient mice

31 March 2020

1 reference

Porcine pancreatic phospholipase A2 stimulates secretin release from secretin-producing cells

31 March 2020

1 reference

Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels

31 March 2020

1 reference

Molecular structure and tissue-specific expression of the mouse pancreatic phospholipase A(2) gene

31 March 2020

1 reference

Type II secretory phospholipase A2 in cardiovascular disease: a mediator in atherosclerosis and ischemic damage to cardiomyocytes?

31 March 2020

1 reference

Structural analysis of phospholipase A2 from functional perspective. 2. Characterization of a molten globule-like state induced by site-specific mutagenesis.

31 March 2020

1 reference

Fatty acid transport across membranes: relevance to nutrition and metabolic pathology

31 March 2020

1 reference

Rapid Flip-flop of Oleic Acid across the Plasma Membrane of Adipocytes

31 March 2020

1 reference

The intestinal fatty acid binding protein is not essential for dietary fat absorption in mice.

31 March 2020

1 reference

Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes

31 March 2020

1 reference

Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP)

31 March 2020

1 reference

Heart CD36 expression is increased in murine models of diabetes and in mice fed a high fat diet

31 March 2020

1 reference

Intestinal lipid absorption is not affected in CD36 deficient mice

31 March 2020

1 reference

Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein

31 March 2020

1 reference

Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality

31 March 2020

1 reference

Mouse fatty acid transport protein 4 (FATP4): characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase

31 March 2020

1 reference

Enzymes of triacylglycerol synthesis and their regulation

31 March 2020

1 reference

Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase

31 March 2020

1 reference

Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2

31 March 2020

1 reference

A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet

31 March 2020

1 reference

Identification of acyl coenzyme A:monoacylglycerol acyltransferase 3, an intestinal specific enzyme implicated in dietary fat absorption

31 March 2020

1 reference

MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine

31 March 2020

1 reference

Increased hepatic monoacylglycerol acyltransferase activity in streptozotocin-induced diabetes: characterization and comparison with activities from adult and neonatal rat liver

31 March 2020

1 reference

Pathogenesis of obesity by food restriction in OLETF rats-increased intestinal monoacylglycerol acyltransferase activities may be a crucial factor

31 March 2020

1 reference

Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia

31 March 2020

1 reference

Crypt cell production rate, enterocyte turnover time and appearance of transport along the jejunal villus of the rat

31 March 2020

1 reference

The role of microsomal triglyceride transfer protein in lipoprotein assembly: an update

31 March 2020

1 reference

A proposed model for the assembly of chylomicrons

31 March 2020

1 reference

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits

31 March 2020

1 reference

Diaminoindanes as microsomal triglyceride transfer protein inhibitors

31 March 2020

1 reference

MTP inhibitor decreases plasma cholesterol levels in LDL receptor-deficient WHHL rabbits by lowering the VLDL secretion

31 March 2020

1 reference

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors

31 March 2020

1 reference

CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans

31 March 2020

1 reference

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes

31 March 2020

1 reference

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

31 March 2020

1 reference

Life without white fat: a transgenic mouse

31 March 2020

1 reference

Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways

31 March 2020

1 reference

Glyceroneogenesis revisited

31 March 2020

1 reference

Overexpression of 1-acyl-glycerol-3-phosphate acyltransferase-alpha enhances lipid storage in cellular models of adipose tissue and skeletal muscle

31 March 2020

1 reference

Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis

31 March 2020

1 reference

Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members

31 March 2020

1 reference

DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women

31 March 2020

1 reference

Posttranscriptional control of the expression and function of diacylglycerol acyltransferase-1 in mouse adipocytes.

31 March 2020

1 reference

Lipopenia and skin barrier abnormalities in DGAT2-deficient mice

31 March 2020

1 reference

DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis

31 March 2020

1 reference

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

31 March 2020

1 reference

Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1

31 March 2020

1 reference

Molecular mechanisms regulating hormone-sensitive lipase and lipolysis

31 March 2020

1 reference

Hydroperoxide-induced oxidative stress impairs heart muscle cell carbohydrate metabolism

31 March 2020

1 reference

The hormone-sensitive lipase gene and body composition: the HERITAGE Family Study

31 March 2020

1 reference

Expression of human hormone-sensitive lipase in white adipose tissue of transgenic mice increases lipase activity but does not enhance in vitro lipolysis

31 March 2020

1 reference

Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis

31 March 2020

1 reference

Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice

31 March 2020

1 reference

Hormone-sensitive lipase null mice exhibit signs of impaired insulin sensitivity whereas insulin secretion is intact

31 March 2020

1 reference

Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity

31 March 2020

1 reference

Crystal structure of brefeldin A esterase, a bacterial homolog of the mammalian hormone-sensitive lipase

31 March 2020

1 reference

Functional studies on native and mutated forms of perilipins. A role in protein kinase A-mediated lipolysis of triacylglycerols.

31 March 2020

1 reference

Functional conservation for lipid storage droplet association among Perilipin, ADRP, and TIP47 (PAT)-related proteins in mammals, Drosophila, and Dictyostelium

31 March 2020

1 reference

Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity

31 March 2020

1 reference

Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice

31 March 2020

1 reference

Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile.

31 March 2020

1 reference

Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription

31 March 2020

1 reference

Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise

31 March 2020

1 reference

Reversing adipocyte differentiation: implications for treatment of obesity

31 March 2020

1 reference

Mitochondrial glycerol phosphate acyltransferase directs the incorporation of exogenous fatty acids into triacylglycerol

31 March 2020

1 reference

Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition

31 March 2020

1 reference

Structural and functional organization of the animal fatty acid synthase

31 March 2020

1 reference

Human fatty acid synthase: properties and molecular cloning

31 March 2020

1 reference

Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology

31 March 2020

1 reference

Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors

31 March 2020

1 reference

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

31 March 2020

1 reference

Hypothalamic malonyl-CoA as a mediator of feeding behavior

31 March 2020

1 reference

Structure-activity studies of cerulenin analogues as protein palmitoylation inhibitors

31 March 2020

1 reference

Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity

31 March 2020

1 reference

Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero

31 March 2020

1 reference

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

31 March 2020

1 reference

Genomics of the human carnitine acyltransferase genes

31 March 2020

1 reference

The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis

31 March 2020

1 reference

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

31 March 2020

1 reference

Lipid oxidation is reduced in obese human skeletal muscle

31 March 2020

1 reference

Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

31 March 2020

1 reference

MCD encodes peroxisomal and cytoplasmic forms of malonyl-CoA decarboxylase and is mutated in malonyl-CoA decarboxylase deficiency

31 March 2020

1 reference

Functional and structural basis of carnitine palmitoyltransferase 1A deficiency.

31 March 2020

1 reference

Correlation between genotype, metabolic data, and clinical presentation in carnitine palmitoyltransferase 2 (CPT2) deficiency.

31 March 2020

1 reference

Carnitine transport by organic cation transporters and systemic carnitine deficiency

31 March 2020

1 reference

Identification of positive and negative determinants of malonyl-CoA sensitivity and carnitine affinity within the amino termini of rat liver- and muscle-type carnitine palmitoyltransferase I

31 March 2020

1 reference

Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition

31 March 2020

1 reference

A single amino acid change (substitution of glutamate 3 with alanine) in the N-terminal region of rat liver carnitine palmitoyltransferase I abolishes malonyl-CoA inhibition and high affinity binding

31 March 2020

1 reference

Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding

31 March 2020

1 reference

Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport

31 March 2020

1 reference

Discovery of a long-chain carbamoyl aminocarnitine derivative, a reversible carnitine palmitoyltransferase inhibitor with antiketotic and antidiabetic activity.

31 March 2020

1 reference

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

31 March 2020

1 reference

Topology of hepatic mitochondrial carnitine palmitoyltransferase I.

31 March 2020

1 reference

Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms

31 March 2020

1 reference

The subcellular localization of acetyl-CoA carboxylase 2

31 March 2020

1 reference

Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein

31 March 2020

1 reference

Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase

31 March 2020

1 reference

Regulation of mammalian acetyl-CoA carboxylase

31 March 2020

1 reference

High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase

31 March 2020

1 reference

AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart

31 March 2020

1 reference

Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR.

31 March 2020

1 reference

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

31 March 2020

1 reference

Cyclohexanedione herbicides are inhibitors of rat heart acetyl-CoA carboxylase

31 March 2020

1 reference

Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals

31 March 2020

1 reference

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase

31 March 2020

1 reference

Recent insights into stearoyl-CoA desaturase-1.

31 March 2020

1 reference

Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid.

31 March 2020

1 reference

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss

31 March 2020

1 reference

Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity

31 March 2020

1 reference

Mechanisms and regulation of biosynthesis of saturated fatty acids

31 March 2020

1 reference

Polyunsaturated fatty acid regulation of gene expression

31 March 2020

1 reference

Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production

31 March 2020

1 reference

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

31 March 2020

1 reference

Malonyl-CoA, fuel sensing, and insulin resistance

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1469

1 reference

Dimensions Publication ID

10 August 2017

1024601516

0 references

1 reference