(Q35857020)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

Delineating the autoimmune mechanisms in Graves' disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

author name string

Syed A Morshed

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Terry F Davies

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

publication date

1 December 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

volume

54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

issue

1-3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

page(s)

191-203

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s12026-012-8312-8

26 January 2020

exact match

0 references

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11 July 2018

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The thyroid-stimulating hormone receptor: impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization, cleavage, and signaling

11 July 2018

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Influence of the TSH receptor gene on susceptibility to Graves' disease and Graves' ophthalmopathy

11 July 2018

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11 July 2018

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B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis.

11 July 2018

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Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis

11 July 2018

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Characterization of thyrotropin receptor antibody-induced signaling cascades

11 July 2018

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Expression of Bcl-2 family proteins in thyrocytes from young patients with immune and nonimmune thyroid diseases

11 July 2018

1 reference

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Identification of apoptotic proteins in thyroid gland from patients with Graves' disease and Hashimoto's thyroiditis

11 July 2018

1 reference

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Autoimmune disease after autologous hematopoietic stem cell transplantation

11 July 2018

1 reference

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Antithyroperoxidase antibody-dependent cytotoxicity in autoimmune thyroid disease.

11 July 2018

1 reference

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Antibody-induced modulation of TSH receptor post-translational processing

11 July 2018

1 reference

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The role of apoptosis in thyroid autoimmunity

11 July 2018

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The genetic basis of thyroid autoimmunity

11 July 2018

1 reference

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The link between Graves' disease and Hashimoto's thyroiditis: a role for regulatory T cells

11 July 2018

1 reference

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Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody

11 July 2018

1 reference

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The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

11 July 2018

1 reference

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The role of stress in the clinical expression of thyroid autoimmunity

11 July 2018

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11 July 2018

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Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population

11 July 2018

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TLR gateways to CD1 function

11 July 2018

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

11 July 2018

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11 July 2018

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1 reference

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Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease.

11 July 2018

1 reference

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Mechanisms regulating lymphocytic infiltration of the thyroid in murine models of thyroiditis

11 July 2018

1 reference

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Thyrotropin receptor-associated diseases: from adenomata to Graves disease

11 July 2018

1 reference

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11 July 2018

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Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

11 July 2018

1 reference

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Dissecting linear and conformational epitopes on the native thyrotropin receptor.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Concentration-dependent regulation of thyrotropin receptor function by thyroid-stimulating antibody.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

CD1: antigen presentation and T cell function

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

HLA and H2 class II transgenic mouse models to study susceptibility and protection in autoimmune thyroid disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

The contribution of immune regulatory and thyroid specific genes to the etiology of Graves' and Hashimoto's diseases

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Amino acid substitutions in the thyroglobulin gene are associated with susceptibility to human and murine autoimmune thyroid disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Chronic thyroiditis and autoimmunization

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Thyroid-stimulating monoclonal antibodies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Thyroglobulin-thyroperoxidase autoantibodies are polyreactive, not bispecific: analysis using human monoclonal autoantibodies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

A monoclonal thyroid-stimulating antibody

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Autoimmune thyroid disease: new models of cell death in autoimmunity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Binding of human thyrotropin receptor peptides to a Graves' disease-predisposing human leukocyte antigen class II molecule

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Association of thyrotrophin receptor antibodies with the clinical features of Graves' ophthalmopathy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

T-cell receptors and autoimmune thyroid disease--signposts for T-cell-antigen driven diseases

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Serum antibodies against megalin (GP330) in patients with autoimmune thyroiditis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Development and characterization of monoclonal antibodies specific for the murine thyrotropin receptor.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

The pathogenesis of Graves' disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

An N-linked glycosylation motif from the noncleaving luteinizing hormone receptor substituted for the homologous region (Gly367 to Glu369) of the thyrotropin receptor prevents cleavage at its second, downstream site

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Processing of the precursors of the human thyroid-stimulating hormone receptor in various eukaryotic cells (human thyrocytes, transfected L cells and baculovirus-infected insect cells).

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

The pathology of autoimmune thyroid disease: a review

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Circulating thyroid hormone autoantibodies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Autoantibodies to the thyrotropin receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Long term follow-up and HLA association in patients with postpartum hypothyroidism.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Analysis of thyrotropin receptors by photoaffinity labelling. Orientation of receptor subunits in the cell membrane

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Autoantigen recognition by thyroid-infiltrating T cells in Graves disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Two-subunit structure of the human thyrotropin receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Evidence for selective accumulation of intrathyroidal T lymphocytes in human autoimmune thyroid disease based on T cell receptor V gene usage

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Graves' IgG recognizes linear epitopes in the human thyrotropin receptor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Fetal and neonatal hyperthyroidism and hypothyroidism due to maternal TSH receptor antibodies

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function

11 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Antibodies to TSH-receptor in thyroid autoimmune disease interact with monoclonal antibodies whose epitopes are broadly distributed on the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

The cysteine-rich amino terminus of the thyrotropin receptor is the immunodominant linear antibody epitope in mice immunized using naked deoxyribonucleic acid or adenovirus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Treatment of autoimmune hyperthyroidism in a murine model of Graves' disease with tumor necrosis factor-family ligand inhibitors suggests a key role for B cell activating factor in disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Suppression of thyrotropin receptor constitutive activity by a monoclonal antibody with inverse agonist activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Tag SNP screening of the PDCD1 gene for association with Graves' disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Prevalence of interrelated autoantibodies in thyroid diseases and autoimmune disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Regulatory T cells in human autoimmune thyroid disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Dendritic cells infected with adenovirus expressing the thyrotrophin receptor induce Graves' hyperthyroidism in BALB/c mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Igs from patients with Graves' disease induce the expression of T cell chemoattractants in their fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

Immunoglobulin activation of T cell chemoattractant expression in fibroblasts from patients with Graves' disease is mediated through the insulin-like growth factor I receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-012-8312-8

The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Rituximab treatment in patients with active Graves' orbitopathy: effects on proinflammatory and humoral immune reactions.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Evaluation of T cell stimulation by thyrotropin-receptor epitopes in Graves' disease.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: an association analysis in Caucasian and Japanese cohorts.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

CTLA4 polymorphisms and ophthalmopathy in Graves' disease patients: association study and meta-analysis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Limited genetic susceptibility to severe Graves' ophthalmopathy: no role for CTLA-4 but evidence for an environmental etiology

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Spatial correlation between thyroid epithelial cells expressing class II MHC molecules and interferon-gamma-containing lymphocytes in human thyroid autoimmune disease

22 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4504182

Detection of functionally different types of pathological autoantibodies against thyrotropin receptor in Graves' patients sera by luminescent immunoprecipitation analysis

22 October 2018

1 reference

12 December 2020

Apoptosis in orbital fibroadipose tissue and its association with clinical features in Graves' ophthalmopathy

1 reference

12 December 2020

Multiple autoimmune diseases after autologous stem-cell transplantation

1 reference

12 December 2020

Autoantibody against Na+/I- symporter in the sera of patients with autoimmune thyroid disease

1 reference

12 December 2020

A novel model for lymphocytic infiltration of the thyroid gland generated by transgenic expression of the CC chemokine CCL21

1 reference

12 December 2020

Infection and autoimmune thyroid disease

1 reference

12 December 2020

The nature of apoptosis in the thyroid and the role it may play in autoimmune thyroid disease

1 reference

12 December 2020

Thyrotropin receptor expression in Graves' orbital adipose/connective tissues: potential autoantigen in Graves' ophthalmopathy

1 reference

12 December 2020

Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease

1 reference

12 December 2020

Characterization of Thyroglobulin Epitopes in Patients with Autoimmune and Non-Autoimmune Thyroid Diseases Using Recombinant Human Monoclonal Thyroglobulin Autoantibodies

1 reference

12 December 2020

Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese

1 reference

12 December 2020

Thyrocytes — not innocent bystanders in autoimmune disease

1 reference

12 December 2020

Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B-cell depletion in one patient unresponsive to steroid immunosuppression

1 reference

12 December 2020

Presence of antideoxyribonucleic acid antibody in patients with hyperthyroidism of Graves' disease

1 reference

12 December 2020

A variant of the Il2ra / Cd25 gene predisposing to graves' disease is associated with increased levels of soluble interleukin-2 receptor

1 reference

12 December 2020

Regulation of Graves' hyperthyroidism with naturally occurring CD4+CD25+ regulatory T cells in a mouse model

1 reference

12 December 2020

Thyroglobulin and thyroid peroxidase share common epitopes recognized by autoantibodies in patients with chronic autoimmune thyroiditis

1 reference

12 December 2020

Intrathyroidal dendritic cells

1 reference

12 December 2020

Peripheral blood and intrathyroidal mononuclear cell populations in patients with autoimmune thyroid disorders enumerated using monoclonal antibodies

1 reference

12 December 2020

Maturation of thyroidal dendritic cells in Graves' disease

1 reference

12 December 2020

Evidence of Limited Variability of Antigen Receptors on Intrathyroidal T Cells in Autoimmune Thyroid Disease

1 reference

12 December 2020

Differential Regulation of Fas-Mediated Apoptosis in Both Thyrocyte and Lymphocyte Cellular Compartments Correlates with Opposite Phenotypic Manifestations of Autoimmune Thyroid Disease

1 reference

12 December 2020

Detection of major T cell epitopes on human thyroid stimulating hormone receptor by overriding immune heterogeneity in patients with Graves' disease

1 reference

12 December 2020

CD1a and CD1c activate intrathyroidal T cells during Graves' disease and Hashimoto's thyroiditis

1 reference

12 December 2020

High efficiency antigen presentation by thyroglobulin-primed murine splenic B cells

1 reference

12 December 2020

Characterization of the thyrotropin binding pocket

1 reference

12 December 2020

Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis

1 reference

12 December 2020

CD8+CD122+ T cells, a newly identified regulatory T subset, negatively regulate Graves' hyperthyroidism in a murine model

1 reference

12 December 2020

Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity

1 reference

12 December 2020

Pathogenesis of Graves' ophthalmopathy

1 reference

12 December 2020

Ia+ T cells in new onset Graves' disease

1 reference

12 December 2020

Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor

1 reference

12 December 2020

10.1007/S12026-012-8312-8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22434518%20AND%20SRC:MED&resulttype=core&format=json