(Q35858082)

English

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

scientific article published in March 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1 reference

based on heuristic

inferred from title

Mitchell R McGill

object named as

Mitchell R McGill

1

1 reference

ORCID Public Data File 2021

author name string

Matthew R Sharpe

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

C David Williams

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Mohammad Taha

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Steven C Curry

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Hartmut Jaeschke

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

language of work or name

0 references

publication date

1 March 2012

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

122

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1574-1583

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Circulating mitochondrial DAMPs cause inflammatory responses to injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Nonprescription use of pain relievers by middle-aged and elderly community-living adults: National Survey on Drug Use and Health

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Patterns of use and public perception of over-the-counter pain relievers: focus on nonsteroidal antiinflammatory drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Apoptosis and necrosis in liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Changing Patterns of Causation and the Use of Transplantation in the United Kingdom

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Toll-like receptor 9 mediates CpG-DNA signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Recent patterns of medication use in the ambulatory adult population of the United States: the Slone survey

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

A Toll-like receptor recognizes bacterial DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

The hepatic inflammatory response after acetaminophen overdose: role of neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Acute liver necrosis following overdose of paracetamol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Therapeutic doses of acetaminophen stimulate the turnover of cysteine and glutathione in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Ultrastructural changes during acute acetaminophen-induced hepatotoxicity in the mouse: a time and dose study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Molecular mechanisms of the hepatotoxicity caused by acetaminophen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

Diseases of the mitochondrial DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

11 July 2018

High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Serum apoptosis markers in acute liver failure: a pilot study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Acute liver failure in Sweden: etiology and outcome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Measurement of serum acetaminophen-protein adducts in patients with acute liver failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Estimates of acetaminophen (Paracetomal)-associated overdoses in the United States

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Role of caspases in acetaminophen-induced liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Effect of N-acetylcysteine on acetaminophen toxicity in mice: relationship to reactive nitrogen and cytokine formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

N-acetyl-p-benzoquinone imine-induced changes in the energy metabolism in hepatocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314460

24 September 2018

The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3'-hydroxyacetanilide, in mouse liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: the protective effect of allopurinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: effects of Ca(2+)-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolic organization of the adult human liver: a comparative study of normal, fibrotic, and cirrhotic liver tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase activation is associated with spontaneous recovery from acute liver failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22378043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI59755

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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