(Q35859218)

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Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics

scientific article published on 2 December 2015

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Europe PubMed Central

PMC publication ID

10 August 2017

Utilizing CMP-Sialic Acid Analogs to Unravel Neisseria gonorrhoeae Lipooligosaccharide-Mediated Complement Resistance and Design Novel Therapeutics (English)

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Europe PubMed Central

PMC publication ID

10 August 2017

Neisseria gonorrhoeae

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11

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Magnus Unemo

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PMC publication ID

10 August 2017

author name string

Sunita Gulati

1

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Europe PubMed Central

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10 August 2017

Ian C Schoenhofen

2

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10 August 2017

Dennis M Whitfield

3

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10 August 2017

Andrew D Cox

4

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10 August 2017

Jianjun Li

5

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10 August 2017

Frank St Michael

6

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10 August 2017

Evgeny V Vinogradov

7

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10 August 2017

Jacek Stupak

8

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10 August 2017

Bo Zheng

9

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10 August 2017

Makoto Ohnishi

10

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10 August 2017

Lisa A Lewis

12

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10 August 2017

Rachel E Taylor

13

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10 August 2017

Corinna S Landig

14

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10 August 2017

Sandra Diaz

15

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10 August 2017

George W Reed

16

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10 August 2017

Ajit Varki

17

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10 August 2017

Peter A Rice

18

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10 August 2017

Sanjay Ram

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10 August 2017

publication date

2 December 2015

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10 August 2017

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10 August 2017

11

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10 August 2017

12

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Europe PubMed Central

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10 August 2017

e1005290

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Europe PubMed Central

PMC publication ID

10 August 2017

copyright license

Creative Commons Attribution 4.0 International

2 December 2015

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4668040/fullTextXML

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α-2,3-sialyltransferase expression level impacts the kinetics of lipooligosaccharide sialylation, complement resistance, and the ability of Neisseria gonorrhoeae to colonize the murine genital tract

1 reference

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Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors

1 reference

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11 July 2018

Structural basis for sialic acid-mediated self-recognition by complement factor H

1 reference

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Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc

1 reference

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11 July 2018

Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future

1 reference

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11 July 2018

Immunization against a saccharide epitope accelerates clearance of experimental gonococcal infection

1 reference

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A simple method for assessment of human anti-Neu5Gc antibodies applied to Kawasaki disease

1 reference

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11 July 2018

Multifarious roles of sialic acids in immunity

1 reference

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11 July 2018

The relative roles of factor H binding protein, neisserial surface protein A, and lipooligosaccharide sialylation in regulation of the alternative pathway of complement on meningococci

1 reference

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11 July 2018

Properdin is critical for antibody-dependent bactericidal activity against Neisseria gonorrhoeae that recruit C4b-binding protein

1 reference

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11 July 2018

Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Chemoenzymatic synthesis of C8-modified sialic acids and related α2-3- and α2-6-linked sialosides.

1 reference

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11 July 2018

Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone

1 reference

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11 July 2018

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Complement control protein factor H: the good, the bad, and the inadequate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Advances in the biology and chemistry of sialic acids

1 reference

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11 July 2018

Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure

1 reference

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11 July 2018

The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors

1 reference

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11 July 2018

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Phosphoethanolamine substitution of lipid A and resistance of Neisseria gonorrhoeae to cationic antimicrobial peptides and complement-mediated killing by normal human serum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Human factor H interacts selectively with Neisseria gonorrhoeae and results in species-specific complement evasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Sialic acid utilization by bacterial pathogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Heptose I glycan substitutions on Neisseria gonorrhoeae lipooligosaccharide influence C4b-binding protein binding and serum resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Lactate acquisition promotes successful colonization of the murine genital tract by Neisseria gonorrhoeae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Alpha-2,3-sialyltransferase enhances Neisseria gonorrhoeae survival during experimental murine genital tract infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Elucidation of the CMP-pseudaminic acid pathway in Helicobacter pylori: synthesis from UDP-N-acetylglucosamine by a single enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Enhanced factor H binding to sialylated Gonococci is restricted to the sialylated lacto-N-neotetraose lipooligosaccharide species: implications for serum resistance and evidence for a bifunctional lipooligosaccharide sialyltransferase in Gonococci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Host-derived sialic acid is incorporated into Haemophilus influenzae lipopolysaccharide and is a major virulence factor in experimental otitis media

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

The Neisseria lipooligosaccharide-specific alpha-2,3-sialyltransferase is a surface-exposed outer membrane protein

1 reference

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11 July 2018

Mucinases and sialidases: their role in the pathogenesis of sexually transmitted infections in the female genital tract

1 reference

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11 July 2018

Sialylation of lipooligosaccharide cores affects immunogenicity and serum resistance of Campylobacter jejuni

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Role of lipooligosaccharide in Opa-independent invasion of Neisseria gonorrhoeae into human epithelial cells

1 reference

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11 July 2018

A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence

1 reference

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11 July 2018

A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Variation of gonococcal lipooligosaccharide structure is due to alterations in poly-G tracts in lgt genes encoding glycosyl transferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Analysis of C3 deposition and degradation on Neisseria meningitidis and Neisseria gonorrhoeae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

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Bacterial vaginosis is associated with prematurity and vaginal fluid mucinase and sialidase: results of a controlled trial of topical clindamycin cream

1 reference

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11 July 2018

Isolation and characterization of lipopolysaccharides, lipooligosaccharides, and lipid A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

An autosomal dominant gene regulates the extent of 9-O-acetylation of murine erythrocyte sialic acids. A probable explanation for the variation in capacity to activate the human alternate complement pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Gonococci in Urethral Exudates possess a Virulence Factor lost on Subculture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Cytidine 5'-monophospho-N-acetylneuraminic acid or a related compound is the low Mr factor from human red blood cells which induces gonococcal resistance to killing by human serum.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

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Conserved lipoproteins of pathogenic Neisseria species bearing the H.8 epitope: lipid-modified azurin and H.8 outer membrane protein

1 reference

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11 July 2018

Epitope expression and partial structural characterization of F62 lipooligosaccharide (Los) of Neisseria gonorrhoeae: IgM monoclonal antibodies (3F11 and 1-1-M) recognize non-reducing termini of the los components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

In vitro and in vivo modification of Neisseria gonorrhoeae lipooligosaccharide epitope structure by sialylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

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Sialidases (neuraminidases) in bacterial vaginosis and bacterial vaginosis-associated microflora

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

The sialylation of gonococcal lipopolysaccharide by host factors: a major impact on pathogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Regulation by membrane sialic acid of β1H-dependent decay-dissociation of amplification C3 convertase of the alternative complement pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Serum bactericidal action and activation of the classic and alternate complement pathways by Neisseria gonorrhoeae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

11 July 2018

Pasteurella multocida CMP-sialic acid synthetase and mutants of Neisseria meningitidis CMP-sialic acid synthetase with improved substrate promiscuity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

24 September 2018

Ceftriaxone-resistant Neisseria gonorrhoeae, Japan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

24 September 2018

Variable degree of alternative complement pathway-mediated hemolysis in Indian visceral leishmaniasis induced by differential expression of 9-O-acetylated sialoglycans

1 reference

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24 September 2018

Identification by mass spectrometry of CMP-NANA in diffusible material released from high M(r) blood cell fractions that confers serum resistance on gonococci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

24 September 2018

Immunological basis of serum resistance of Neisseria gonorrhoeae.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

24 September 2018

Inhibition of the alternative pathway of human complement by structural analogues of sialic acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4668040

24 September 2018

Complement Processing and Immunoglobulin Binding toNeisseria gonorrhoeaeDetermined In Vitro Simulates In Vivo Effects

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PPAT.1005290

21 January 2018

Synthesis of 9-O-acyl- and 4-O-acetyl-sialic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic synthesis and properties of glycoconjugates with legionaminic acid as a replacement for neuraminic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Newly Discovered Sialidase from Gardnerella Vaginalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibodies to N‐terminal peptides of gonococcal porin are bactericidal when gonococcal lipopolysaccharide is not sialylated

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complement-mediated bacterial killing assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic changes of sialidase in human cervical mucus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sialyltransferases with enhanced legionaminic acid transferase activity for the preparation of analogs of sialoglycoconjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a recombinant Neisseria meningitidis alpha-2,3-sialyltransferase and its acceptor specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of mono-O-acetylated N-acetylneuraminic acids in human and rat sera by fluorometric high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/26630657

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PPAT.1005290

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

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