(Q35859939)

English

The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.

scientific article published on 18 May 2015

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scholarly article

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8 March 2020

The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence (English)

1 reference

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8 March 2020

Mycobacterium tuberculosis

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3

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8 March 2020

Patricia A DiGiuseppe Champion

5

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8 March 2020

Robert B Abramovitch

6

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8 March 2020

Christopher J Colvin

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object named as

Christopher J Colvin

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8 March 2020

author name string

Benjamin K Johnson

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8 March 2020

Felix Mba Medie

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18 May 2015

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8 March 2020

Antimicrobial Agents and Chemotherapy

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8 March 2020

59

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8 March 2020

8

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8 March 2020

4436-4445

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8 March 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4505220/fullTextXML

based on heuristic

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Macrophage infection models for Mycobacterium tuberculosis

1 reference

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1 reference

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Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion.

1 reference

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Slow growth of Mycobacterium tuberculosis at acidic pH is regulated by phoPR and host-associated carbon sources

1 reference

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The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.

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Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis

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Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell

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Linking the transcriptional profiles and the physiological states of Mycobacterium tuberculosis during an extended intracellular infection

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11 July 2018

Adaptation to environmental stimuli within the host: two-component signal transduction systems of Mycobacterium tuberculosis

1 reference

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11 July 2018

Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis

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Bacterial carbonic anhydrases as drug targets: toward novel antibiotics?

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aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome

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11 July 2018

Physiological carbon dioxide, bicarbonate, and pH sensing

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11 July 2018

Anti-virulence strategies to combat bacteria-mediated disease

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11 July 2018

Decreased outer membrane permeability protects mycobacteria from killing by ubiquitin-derived peptides

1 reference

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11 July 2018

Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response

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11 July 2018

Cytoplasmic pH measurement and homeostasis in bacteria and archaea

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11 July 2018

Acid resistance in Mycobacterium tuberculosis

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11 July 2018

PhoP: a missing piece in the intricate puzzle of Mycobacterium tuberculosis virulence

1 reference

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Targeting QseC signaling and virulence for antibiotic development

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11 July 2018

Secreted transcription factor controls Mycobacterium tuberculosis virulence

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11 July 2018

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP

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11 July 2018

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

1 reference

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11 July 2018

Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.

1 reference

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11 July 2018

The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis

1 reference

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11 July 2018

The live Mycobacterium tuberculosis phoP mutant strain is more attenuated than BCG and confers protective immunity against tuberculosis in mice and guinea pigs

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The virulence-associated two-component PhoP-PhoR system controls the biosynthesis of polyketide-derived lipids in Mycobacterium tuberculosis

1 reference

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11 July 2018

Acid acclimation by Helicobacter pylori

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Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization

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11 July 2018

An essential role for phoP in Mycobacterium tuberculosis virulence

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Relations among IOP reduction, ocular disposition and pharmacology of the carbonic anhydrase inhibitor ethoxzolamide

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EspR, a regulator of the ESX-1 secretion system in Mycobacterium tuberculosis, is directly regulated by the two-component systems MprAB and PhoPR.

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Ethoxzolamide (cardrase) in the management of chronic simple glaucoma.

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Laboratory and clinical observations on ethoxzolamide (cardrase) as a diuretic agent

1 reference

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inferred from PubMed ID database lookup

Micro-method for the measurement of carbonic anhydrase activity in cellular homogenates

1 reference

https://pubmed.ncbi.nlm.nih.gov/25987613

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inferred from PubMed ID database lookup

The effects of ethoxzolamide (cardrase) on intraocular pressure

1 reference

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Mycobacterium tuberculosis Invasion of Macrophages: Linking Bacterial Gene Expression to Environmental Cues

1 reference

https://pubmed.ncbi.nlm.nih.gov/25987613

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inferred from PubMed ID database lookup

Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/25987613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of ethoxzolamide in the iris/ciliary body of the rabbit eye by high-performance liquid chromatography: comparison of tissue levels following intravenous and topical administrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/25987613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00719-15

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25987613%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25987613%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25987613%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

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