(Q35861714)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Semiphysiologically Based Pharmacokinetic Model of Leflunomide Disposition in Rheumatoid Arthritis Patients (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Michael D Wiese

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

David Foster

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

author name string

S M Proudman

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

C E O'Doherty

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

R N Upton

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

publication date

15 June 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

CPT: pharmacometrics & systems pharmacology

20 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

page(s)

362-371

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

20 February 2020

1 reference

10 June 2022

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&rettype=xml&id=4505830

cites work

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1 reference

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Basic Concepts in Population Modeling, Simulation, and Model-Based Drug Development

11 July 2018

1 reference

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Pharmacokinetic evaluation of teriflunomide for the treatment of multiple sclerosis.

11 July 2018

1 reference

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Polymorphisms in cytochrome P450 2C19 enzyme and cessation of leflunomide in patients with rheumatoid arthritis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Use of a local sensitivity analysis to inform study design based on a mechanistic toxicokinetic model for γ-hydroxybutyric acid

11 July 2018

1 reference

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CYP-mediated therapeutic protein-drug interactions: clinical findings, proposed mechanisms and regulatory implications

11 July 2018

1 reference

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Leflunomide inhibition of BK virus replication in renal tubular epithelial cells

11 July 2018

1 reference

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11 July 2018

Bile acid transporters

1 reference

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Mechanistic basis of using body size and maturation to predict clearance in humans

11 July 2018

1 reference

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Kinetic determinants of hepatic clearance: plasma protein binding and hepatic uptake

11 July 2018

1 reference

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Mechanism-based concepts of size and maturity in pharmacokinetics

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Response-driven combination therapy with conventional disease-modifying antirheumatic drugs can achieve high response rates in early rheumatoid arthritis with minimal glucocorticoid and nonsteroidal anti-inflammatory drug use

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Usefulness of monitoring free (unbound) concentrations of therapeutic drugs in patient management

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Physiologically based pharmacokinetic modelling: a sound mechanistic basis is needed

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Population pharmacokinetics and association between A77 1726 plasma concentrations and disease activity measures following administration of leflunomide to people with rheumatoid arthritis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Therapeutic drug monitoring of A77 1726, the active metabolite of leflunomide: serum concentrations predict response to treatment in patients with rheumatoid arthritis.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatography

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Changes in plasma protein binding have little clinical relevance

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Cytochromes and cytokines: changes in drug disposition in animals during an acute phase response: a mini-review

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Iodothyronines in human bile.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

The rheumatoid arthritis susceptibility polymorphism PTPN22 C1858T is not associated with leflunomide response or toxicity.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Total and free plasma concentrations of the active metabolite of leflunomide in relation to therapeutic outcome in kidney transplant recipients with BK-virus nephropathy

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Effect of ABCG2 genotypes on the pharmacokinetics of A771726, an active metabolite of prodrug leflunomide, and association of A771726 exposure with serum uric acid level.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Leflunomide therapy for polyomavirus-induced allograft nephropathy: efficient BK virus elimination without increased risk of rejection

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Investigation of the influence of CYP1A2 and CYP2C19 genetic polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) pharmacokinetics in leflunomide-treated patients with rheumatoid arthritis.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Population pharmacokinetics of the active metabolite of leflunomide in pediatric subjects with polyarticular course juvenile rheumatoid arthritis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Quantification of lean bodyweight.

24 September 2018

1 reference

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Is the ileal bile acid-binding protein (I-BABP) gene involved in cholesterol homeostasis?

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505830

Quantitation of total and free teriflunomide (A77 1726) in human plasma by LC-MS/MS

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26225264

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Association of DHODH haplotype variants and response to leflunomide treatment in rheumatoid arthritis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26225264

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Individualization of leflunomide dosing in rheumatoid arthritis patients

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26225264

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/PSP4.46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

26225264

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26225264%20AND%20SRC:MED&resulttype=core&format=json