(Q35869426)

English

Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.

scientific article published on 26 April 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

object named as

Robert C Bast

9

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author name string

Pijus K Mandal

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Fengqin Gao

2

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Europe PubMed Central

PMC publication ID

10 August 2017

Zhen Lu

3

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10 August 2017

Zhiyong Ren

4

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10 August 2017

Rajagopal Ramesh

5

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Europe PubMed Central

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10 August 2017

J Sanderson Birtwistle

6

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Europe PubMed Central

PMC publication ID

10 August 2017

Kumaralal K Kaluarachchi

7

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Xiaomin Chen

8

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Europe PubMed Central

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10 August 2017

Warren S Liao

10

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10 August 2017

John S McMurray

11

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10 August 2017

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publication date

26 April 2011

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10 August 2017

Journal of Medicinal Chemistry

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10 August 2017

54

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Europe PubMed Central

PMC publication ID

10 August 2017

10

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

3549-3563

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors.

1 reference

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The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

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27 July 2018

Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.

1 reference

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27 July 2018

Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

1 reference

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27 July 2018

Synthesis of phosphatase-stable, cell-permeable peptidomimetic prodrugs that target the SH2 domain of Stat3

1 reference

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27 July 2018

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

1 reference

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27 July 2018

Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.

1 reference

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27 July 2018

Chemical probes that competitively and selectively inhibit Stat3 activation

1 reference

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27 July 2018

Function of mitochondrial Stat3 in cellular respiration

1 reference

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27 July 2018

Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

1 reference

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27 July 2018

STAT 3 as a target for cancer drug discovery

1 reference

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27 July 2018

Crystal structure of unphosphorylated STAT3 core fragment

1 reference

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27 July 2018

Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains

1 reference

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27 July 2018

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization

1 reference

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27 July 2018

Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics

1 reference

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27 July 2018

Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells

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27 July 2018

Structure of the unphosphorylated STAT5a dimer

1 reference

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27 July 2018

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

1 reference

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27 July 2018

Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif

1 reference

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27 July 2018

The STATs of cancer--new molecular targets come of age

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27 July 2018

Autocrine Signalling Through erbB Receptors Promotes Constitutive Activation of Protein Kinase B/Akt in Breast Cancer Cell Lines

1 reference

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27 July 2018

Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor

1 reference

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

1 reference

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Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice

1 reference

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27 July 2018

Prodrugs of biologically active phosphate esters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319156

27 July 2018

Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3.

1 reference

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Transcription factors as targets for cancer therapy

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Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation

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STATs in oncogenesis

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Searching for specificity in SH domains

1 reference

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Three-dimensional structure of the Stat3beta homodimer bound to DNA

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Focal adhesion kinase tyrosine-861 is a major site of phosphorylation by Src.

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Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation

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Synthesis and antitumor evaluation of bis[(pivaloyloxy)methyl] 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP): a strategy to introduce nucleotides into cells

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Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

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SH2 domains recognize specific phosphopeptide sequences

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Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

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Design, synthesis, and evaluation of peptidomimetics containing Freidinger lactams as STAT3 inhibitors.

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Roles of unphosphorylated STATs in signaling

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Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases.

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Structural basis for the binding of high affinity phosphopeptides to Stat3.

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STAT3: a critical transcription activator in angiogenesis.

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Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor

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Identification of a high-affinity phosphopeptide inhibitor of Stat3.

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based on heuristic

inferred from PubMed ID database lookup

An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/21486047

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New syntheses of tetrazolylmethylphenylalanine and O-malonyltyrosine as pTyr mimetics for the design of STAT3 dimerization inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21486047

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based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via 'click chemistry'

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM2000882

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

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