(Q35869879)

English

The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin

scientific article published on 28 January 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

The naphthol selective estrogen receptor modulator (SERM), LY2066948, is oxidized to an o-quinone analogous to the naphthol equine estrogen, equilenin (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

7

object named as

Judy L Bolton

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

author name string

Teshome B Gherezghiher

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Bradley Michalsen

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

R Esala P Chandrasena

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Zhihui Qin

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Johann Sohn

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Gregory R J Thatcher

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

publication date

28 January 2012

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Chemico-biological Interactions

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Europe PubMed Central

PMC publication ID

10 August 2017

196

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1-2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

1-10

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Estrogen induces apoptosis in estrogen deprivation-resistant breast cancer through stress responses as identified by global gene expression across time

1 reference

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SERMs: progress and future perspectives

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Lasofoxifene in postmenopausal women with osteoporosis

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Endometrial safety: a key hurdle for selective estrogen receptor modulators in development

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Designing the ideal selective estrogen receptor modulator--an achievable goal?

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Structural modulation of oxidative metabolism in design of improved benzothiophene selective estrogen receptor modulators

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Selective estrogen receptor modulators: an update on recent clinical findings

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Potential mechanisms of estrogen quinone carcinogenesis

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Estrogen carcinogenesis in breast cancer

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1 reference

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Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.

1 reference

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Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.

1 reference

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Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones

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Selective estrogen receptor modulation: concept and consequences in cancer

1 reference

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11 July 2018

Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms

1 reference

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11 July 2018

Quinoids, quinoid radicals, and phenoxyl radicals formed from estrogens and antiestrogens

1 reference

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11 July 2018

Regioselective oxidation of phenols to o-quinones with o-iodoxybenzoic acid (IBX)

1 reference

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11 July 2018

Catechin metabolism: glutathione conjugate formation catalyzed by tyrosinase, peroxidase, and cytochrome p450.

1 reference

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11 July 2018

Role of quinones in toxicology.

1 reference

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Tamoxifen, raloxifene, and the prevention of breast cancer

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Cytochrome P-450 3A4: regulation and role in drug metabolism

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Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

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Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines

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Tyrosinase: a comprehensive review of its mechanism.

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Tamoxifen and the induction of cancer.

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1 reference

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Tyrosinase-catalyzed oxidation of 17beta-estradiol: structure elucidation of the products formed beyond catechol estrogen quinones

1 reference

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319273

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319273

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Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA.

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319273

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4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319273

24 September 2018

Tamoxifen-DNA adducts detected in the endometrium of women treated with tamoxifen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319273

24 September 2018

Tamoxifen, Raloxifene, and the Prevention of Breast Cancer1

1 reference

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24 September 2018

The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319273

24 September 2018

Bioreductive activation of catechol estrogen-ortho-quinones: aromatization of the B ring in 4-hydroxyequilenin markedly alters quinoid formation and reactivity.

1 reference

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o-Methoxy-4-alkylphenols That Form Quinone Methides of Intermediate Reactivity Are the Most Toxic in Rat Liver Slices

1 reference

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24 September 2018

A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22290292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of steroid hormones and antisteroids on alkaline phosphatase activity in human endometrial cancer cells (Ishikawa line)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22290292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative metabolism of butylated hydroxytoluene by hepatic and pulmonary microsomes from rats and mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22290292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22290292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of cytochrome P450-catalyzed aromatic hydroxylation of estrogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/22290292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/22290292

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CBI.2012.01.004

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

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